Substrates for peptidase M27.004: botulinum neurotoxin X

Summary Alignment Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
synaptobrevin homolog YKT6	O15498	1-198	peptide-Lys173+Ser-peptide	P	NT	Leu	Val	Ser	Lys	Ser	Glu	Val	Leu	Masuyer et al., 2018
vesicle-associated membrane protein 1	P23763	1-118	peptide-Arg68+Ala-peptide	P	NT	Leu	Asp	Asp	Arg	Ala	Asp	Ala	Leu	Masuyer et al., 2018
vesicle-associated membrane protein 2	P63027	1-116	peptide-Arg66+Ala-peptide	P	NT	Leu	Asp	Asp	Arg	Ala	Asp	Ala	Leu	Masuyer et al., 2018
vesicle-associated membrane protein 3	Q15836	1-100	peptide-Arg49+Ala-peptide	P	NT	Leu	Asp	Asp	Arg	Ala	Asp	Ala	Leu	Masuyer et al., 2018
vesicle-associated membrane protein 4	O75379	1-141	peptide-Lys87+Ser-peptide	P	NT	Leu	Gln	Asp	Lys	Ser	Glu	Ser	Leu	Masuyer et al., 2018
vesicle-associated membrane protein 5	O95183	1-116	peptide-Arg40+Ser-peptide	P	NT	Leu	Gln	Gln	Arg	Ser	Asp	Gln	Leu	Masuyer et al., 2018