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Substrates for peptidase M24.026: aminopeptidase P3

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
37S ribosomal protein RSM28, mitochondrial Q03430 14-361 Tyr14+Ser-peptide P MS - - - Tyr Ser Thr Ser Val Vogtle et al., 2009
54S ribosomal protein L11, mitochondrial P36521 31-249 Tyr31+Ala-peptide P MS - - - Tyr Ala Leu Ala Ser Vogtle et al., 2009
54S ribosomal protein L41, mitochondrial P32387 34-263 Leu34+Ala-peptide P MS - - - Leu Ala Ser Val Val Vogtle et al., 2009
aconitate hydratase, mitochondrial P19414 16-778 Leu16+Ala-peptide P MS - - - Leu Ala Thr Val Ser Vogtle et al., 2009
acyl carrier protein, mitochondrial P32463 36-125 Tyr36+Ser-peptide P MS - - - Tyr Ser Ala Asn Leu Vogtle et al., 2009
ATP synthase subunit delta, mitochondrial Q12165 22-160 Tyr22+Ala-peptide P MS - - - Tyr Ala Glu Ala Ala Vogtle et al., 2009
ATP synthase subunit gamma, mitochondrial P38077 33-311 Tyr33+Ala-peptide P MS - - - Tyr Ala Thr Leu Lys Vogtle et al., 2009
ATPase inhibitor, mitochondrial P01097 22-85 Tyr22+Ser-peptide P MS - - - Tyr Ser Glu Gly Ser Vogtle et al., 2009
ATPase-stabilizing factor 9 kDa, mitochondrial P01098 23-86 Tyr23+Ser-peptide P MS - - - Tyr Ser Asp Gly Pro Vogtle et al., 2009
citrate synthase, mitochondrial P00890 37-479 Tyr37+Ser-peptide P MS - - - Tyr Ser Ser Ala Ser Vogtle et al., 2009
cytochrome b-c1 complex subunit 1, mitochondrial P07256 18-457 Leu18+Ala-peptide P MS - - - Leu Ala Thr Ala Val Vogtle et al., 2009
cytochrome c oxidase assembly protein COX11, mitochondrial P19516 45-300 Tyr45+Ser-peptide P MS - - - Tyr Ser Val Asn Ser Vogtle et al., 2009
cytochrome c oxidase subunit 6, mitochondrial P00427 40-148 Tyr40+Ser-peptide P MS - - - Tyr Ser Asp Ala His Vogtle et al., 2009
D-lactate dehydrogenase [cytochrome] 2, mitochondrial P46681 36-530 Tyr36+Ser-peptide P MS - - - Tyr Ser Thr Lys Ile Vogtle et al., 2009
delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial P07275 16-575 Phe16+Ser-peptide P MS - - - Phe Ser Gln Leu Gly Vogtle et al., 2009
dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial P12695 28-482 Tyr28+Ala-peptide P MS - - - Tyr Ala Ser Tyr Pro Vogtle et al., 2009
glutaredoxin-2, mitochondrial P17695 30-143 Leu30+Ser-peptide P MS - - - Leu Ser Thr Pro Lys Vogtle et al., 2009
grpE protein homolog, mitochondrial P38523 43-228 Tyr44+Ser-peptide P MS - - - Tyr Ser Asp Glu Ala Vogtle et al., 2009
heat shock protein 60, mitochondrial P19882 21-572 Tyr21+Ser-peptide P MS - - - Tyr Ser Ser His Lys Vogtle et al., 2009
homoisocitrate dehydrogenase, mitochondrial P40495 15-371 Leu15+Ala-peptide P MS - - - Leu Ala Ser Asn Ala Vogtle et al., 2009
isocitrate dehydrogenase [NAD] subunit 2, mitochondrial P28241 15-369 Leu15+Ala-peptide P MS - - - Leu Ala Thr Val Lys Vogtle et al., 2009
Leu-Pro-Ala Leu+Pro-Ala S - - - Leu Pro Ala - - Singh et al., 2017
Leu-Pro-Ala Leu+Pro-Ala S - - - Leu Pro Ala - - Singh et al., 2017
Leu-Pro-Ala Leu+Pro-Ala S - - - Leu Pro Ala - - Singh et al., 2017
lysyl-tRNA synthetase, mitochondrial P32048 29-576 Tyr29+Ser-peptide P MS - - - Tyr Ser Leu Ala His Vogtle et al., 2009
Met-Pro-Ala Met+Pro-Ala S - - - Met Pro Ala - - Singh et al., 2017
Met-Pro-Ala Met+Pro-Ala S - - - Met Pro Ala - - Singh et al., 2017
Met-Pro-Ala Met+Pro-Ala S - - - Met Pro Ala - - Singh et al., 2017
mitochondrial import inner membrane translocase subunit TIM21 P53220 42-239 Tyr42+Ser-peptide P MS - - - Tyr Ser Asn Gly Thr Vogtle et al., 2009
mitochondrial import inner membrane translocase subunit TIM21 P53220 41-239 Leu41+Tyr-peptide P MS - - - Leu Tyr Ser Asn Gly Vogtle et al., 2009
mitochondrial-processing peptidase subunit alpha P11914 10-482 Tyr10+Ser-peptide P MS - - - Tyr Ser Asn Ile Ala Vogtle et al., 2009
mitochondrial-processing peptidase subunit beta P10507 16-462 Leu16+Ser-peptide P MS - - - Leu Ser Thr Ile Ser Vogtle et al., 2009
NAD-dependent malic enzyme, mitochondrial P36013 39-669 Tyr39+Ser-peptide P MS - - - Tyr Ser Ser Asn Thr Vogtle et al., 2009
Phe-Pro-Ala Phe+Pro-Ala S - - - Leu Pro Ala - - Singh et al., 2017
Phe-Pro-Ala Phe+Pro-Ala S - - - Leu Pro Ala - - Singh et al., 2017
Phe-Pro-Ala Phe+Pro-Ala S - - - Leu Pro Ala - - Singh et al., 2017
phenylalanyl-tRNA synthetase, mitochondrial P08425 17-469 Tyr17+Ser-peptide P MS - - - Tyr Ser Thr Leu Lys Vogtle et al., 2009
potassium-activated aldehyde dehydrogenase, mitochondrial P46367 24-519 Phe24+Ser-peptide P MS - - - Phe Ser His Leu Pro Vogtle et al., 2009
presequence translocated-associated motor subunit PAM17, mitochondrial P36147 37-197 Tyr37+Ser-peptide P MS - - - Tyr Ser Gln Pro Ala Vogtle et al., 2009
probable alanine aminotransferase, mitochondrial P52893 78-592 Leu78+Ser-peptide P MS - - - Leu Ser Gly Gln Ser Vogtle et al., 2009
protein ATP11, mitochondrial P32453 35-318 Tyr35+Ser-peptide P MS - - - Tyr Ser Ser Ser Pro Vogtle et al., 2009
protein FMP16, mitochondrial Q12497 30-93 Phe30+Pro-peptide P MS - - - Phe Pro His Leu Lys Vogtle et al., 2009
putative thiosulfate sulfurtransferase FMP31, mitochondrial Q08742 25-149 Phe25+Thr-peptide P MS - - - Phe Thr Thr Lys Ala Vogtle et al., 2009
succinate dehydrogenase assembly factor 2, mitochondrial Q08230 36-162 Phe36+Ser-peptide P MS - - - Phe Ser Ser Asp Lys Vogtle et al., 2009
Tyr-Ala-Ala Tyr+Ala-Ala S - - - Tyr Ala Ala - - Singh et al., 2017
Tyr-Ala-Ala Tyr+Ala-Ala S - - - Tyr Ala Ala - - Singh et al., 2017
Tyr-Ala-Ala Tyr+Ala-Ala S - - - Tyr Ala Ala - - Singh et al., 2017
Tyr-Pro-Ala Tyr+Pro-Ala S - - - Tyr Pro Ala - - Singh et al., 2017
Tyr-Pro-Ala Tyr+Pro-Ala S - - - Tyr Pro Ala - - Singh et al., 2017
Tyr-Pro-Ala Tyr+Pro-Ala S - - - Tyr Pro Ala - - Singh et al., 2017
Tyr-Ser-Ser Tyr+Ser-Ser S - - - Tyr Ser Ser - - Singh et al., 2017
Tyr-Ser-Ser Tyr+Ser-Ser S - - - Tyr Ser Ser - - Singh et al., 2017
Tyr-Ser-Ser Tyr+Ser-Ser S - - - Tyr Ser Ser - - Singh et al., 2017
Tyr-Ser-Ser-Ala-Ala-Ala-Ala Tyr+Ser-Ser-Ala-Ala-Ala-Ala S - - - Tyr Ser Ser Ala Ala Singh et al., 2017
Tyr-Ser-Ser-Ala-Ala-Ala-Ala Tyr+Ser-Ser-Ala-Ala-Ala-Ala S - - - Tyr Ser Ser Ala Ala Singh et al., 2017
Tyr-Ser-Ser-Ala-Ala-Ala-Ala Tyr+Ser-Ser-Ala-Ala-Ala-Ala S - - - Tyr Ser Ser Ala Ala Singh et al., 2017
tyrosyl-tRNA synthetase, mitochondrial P48527 37-492 Tyr37+Ser-peptide P MS - - - Tyr Ser Gln Pro Ser Vogtle et al., 2009
uncharacterized mitochondrial membrane protein FMP10 P40098 13-244 Tyr13+Thr-peptide P MS - - - Tyr Thr Asn Gly Val Vogtle et al., 2009
uncharacterized oxidoreductase YHL021C P23180 23-465 Tyr23+Thr-peptide P MS - - - Tyr Thr Ser Ala Ala Vogtle et al., 2009
uncharacterized protein YMR157C Q03798 40-255 Tyr40+Ser-peptide P MS - - - Tyr Ser Ser Thr Asp Vogtle et al., 2009

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