Substrates for peptidase M24.004: aminopeptidase P (bacteria)

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
Arg-Pro-Pro Arg+Pro-Pro N - - - Arg Pro Pro - - Simmons, 2004
consensus X-Pro bond X+Pro N - - NPe Xaa Pro - - - Simmons, 2004
Gly-Pro-NHMec Gly+Pro-NHMec S - - - Gly Pro AMC - - Simmons, 2004
Gly-Pro-NHNap Gly+Pro-NHNap S - - - Gly Pro NAP - - Simmons, 2004
Gly-Pro-NHPhNO2 Gly+Pro-NHPhNO2 S - - - Gly Pro NAN - - Simmons, 2004
Met-Ala-Ala Met+Ala-Ala S - - - Met Ala Ala - - Singh et al., 2017
Met-Pro-Ala Met+Pro-Ala S - - - Met Pro Ala - - Singh et al., 2017
Phe-Pro Phe+Pro N - - - Phe Pro - - - Simmons, 2004
Tyr-Ala-Ala Tyr+Ala-Ala S - - - Tyr Ala Ala - - Singh et al., 2017