Substrates for peptidase M14.003: carboxypeptidase B

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
Bz-Gly-Arg			Bz-Gly+Arg	S	-	-	Bz	Gly	Arg	-	-	-	Aviles & Vendrell, 2004
Bz-Gly-Lys			Bz-Gly+Lys	S	-	-	Bz	Gly	Lys	-	-	-	Aviles & Vendrell, 2004
cholecystokinin	P01355	21-106	peptide-Arg105+Arg	P	Asp	Phe	Gly	Arg	Arg	-	-	-	Wang et al., 1998
cholecystokinin	P01355	21-105	peptide-Gly104+Arg	P	Met	Asp	Phe	Gly	Arg	-	-	-	Wang et al., 1998
furylacryloyl-Ala-Arg (FAAR)			furylacryloyl-Ala+Arg	S	-	-	FA	Ala	Arg	-	-	-	Aviles & Vendrell, 2004
furylacryloyl-Ala-Lys (FAAK)			furylacryloyl-Ala+Lys	S	-	-	FA	Ala	Lys	-	-	-	Bayes et al., 2005
N-(4-methoxyphenyl-azoformyl)-Arg-OH			N-(4-methoxyphenyl-azoformyl)+Arg-OH	S	-	-	-	MFA	Arg	-	-	-	Pallares et al., 2005