Substrates for peptidase M12.149: horrilysin

Summary Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
insulin A chain (oxidized) P01317 85-105 Gly-Ile-Val-Glu-Gln-Cya-Cya-Ala-Ser-Val-Cya-Ser+Leu-Tyr-Gln-Leu-Glu-Asn-Tyr-Cya-Asn N Ser Val Cya Ser Leu Tyr Gln Leu Bjarnason & Fox, 2004
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala+Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala N Leu Val Glu Ala Leu Tyr Leu Val Fox et al., 1986
melittin P01501 44-69 Gly-Ile+Gly-Ala-Val-Leu-Lys-Val-Leu-Thr-Thr-Gly-Leu-Pro-Ala-Leu-Ile-Ser-Trp-Ile-Lys-Arg-Lys-Arg-Gln-Gln-NH2 N - - Gly Ile Gly Ala Val Leu Bjarnason & Fox, 2004
melittin P01501 44-69 Gly-Ile-Gly-Ala-Val-Leu-Lys-Val-Leu-Thr-Thr-Gly-Leu-Pro+Ala-Leu-Ile-Ser-Trp-Ile-Lys-Arg-Lys-Arg-Gln-Gln-NH2 N Thr Gly Leu Pro Ala Leu Ile Ser Bjarnason & Fox, 2004
melittin P01501 44-69 Gly-Ile-Gly-Ala-Val-Leu-Lys-Val-Leu-Thr-Thr-Gly-Leu-Pro-Ala-Leu-Ile-Ser+Trp-Ile-Lys-Arg-Lys-Arg-Gln-Gln-NH2 N Ala Leu Ile Ser Trp Ile Lys Arg Bjarnason & Fox, 2004