Substrates for peptidase M12.022: ADAM25 H6

Summary Alignment Sequences Sequence features Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
Zinc metalloproteinase-disintegrin brevilysin-H6 P0C7B0 192-610 Peptide-Leu289+Leu-Peptide P - Asn Ala Gln Leu Leu Thr Ala Ile Fujimura et al., 2000
Zinc metalloproteinase-disintegrin brevilysin-H6 P0C7B0 192-610 Peptide-Asp398+Ile-Peptide P - Leu Gly Thr Asp Ile Val Ser Pro Fujimura et al., 2000