Substrates for peptidase M12.018: mammalian-type tolloid-like 2 protein

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
Collagen alpha-1(VII) chain	Q02388	17-2944	peptide-Ala2821+Asp-peptide	P	NT	Ser	Tyr	Ala	Ala	Asp	Thr	Ala	Gly	Rattenholl et al., 2002
Dentin matrix acidic phosphoprotein 1	O55188	17-503	peptide-Ser212+Asp-peptide	P	NT	Gly	Met	Gln	Ser	Asp	Asp	Pro	Glu	Steiglitz et al., 2003
growth/differentiation factor 8 precursor	O08689	25-376	peptide-Arg99+Asp-peptide	P		Asp	Val	Gln	Arg	Asp	Asp	Ser	Ser	Wolfman et al., 2003
Mimecan	P19879	20-299	peptide-Lys76+Asp-peptide	P	NT	Gln	Leu	Gln	Lys	Asp	Glu	Asn	Ile	Ge et al., 2004
prolysyl oxidase	P28300	22-417	peptide-Gly169+Asp-peptide	P		Gly	Met	Val	Gly	Asp	Asp	Pro	Tyr	Uzel et al., 2001	16710
Protein-lysine 6-oxidase precursor	P16636	22-411	peptide-Gly162+Asp-peptide	P	NT	Arg	Met	Val	Gly	Asp	Asp	Pro	Tyr	Uzel et al., 2001