Substrates for peptidase M10.063: PrtA peptidase (Photorhabdus-type)

Summary Alignment Tree Sequences Sequence features Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
Ac-Glu-Leu-Tyr-Ala-Ala-Glu-NH2			Ac-Glu-Leu-Tyr+Ala-Ala-Glu-NH2	S		Ac	Glu	Leu	Tyr	Ala	Ala	Glu	NH2	Marokhazi et al., 2007
Ac-Glu-Leu-Tyr-Ala-Leu-Glu-NH2			Ac-Glu-Leu-Tyr+Ala-Leu-Glu-NH2	S		Ac	Glu	Leu	Tyr	Ala	Leu	Glu	NH2	Marokhazi et al., 2007
Ac-Glu-Leu-Tyr-Ala-Val-Glu-NH2			Ac-Glu-Leu-Tyr+Ala-Val-Glu-NH2	S		Ac	Glu	Leu	Tyr	Ala	Val	Glu	NH2	Marokhazi et al., 2007
Ac-Glu-Leu-Tyr-Leu-Ala-Glu-NH2			Ac-Glu-Leu-Tyr+Leu-Ala-Glu-NH2	S		Ac	Glu	Leu	Tyr	Leu	Ala	Glu	NH2	Marokhazi et al., 2007
Ac-Glu-Leu-Tyr-Leu-Leu-Glu-NH2			Ac-Glu-Leu-Tyr+Leu-Leu-Glu-NH2	S		Ac	Glu	Leu	Tyr	Leu	Leu	Glu	NH2	Marokhazi et al., 2007
Ac-Glu-Leu-Tyr-Leu-Val-Glu-NH2			Ac-Glu-Leu-Tyr+Leu-Val-Glu-NH2	S		Ac	Glu	Leu	Tyr	Leu	Val	Glu	NH2	Marokhazi et al., 2007
Ac-Glu-Val-Tyr-Ala-Ala-Glu-NH2			Ac-Glu-Val-Tyr+Ala-Ala-Glu-NH2	S		Ac	Glu	Val	Tyr	Ala	Ala	Glu	NH2	Marokhazi et al., 2007
Ac-Glu-Val-Tyr-Ala-Leu-Glu-NH2			Ac-Glu-Val-Tyr+Ala-Leu-Glu-NH2	S		Ac	Glu	Val	Tyr	Ala	Leu	Glu	NH2	Marokhazi et al., 2007
Ac-Glu-Val-Tyr-Ala-Val-Glu-NH2			Ac-Glu-Val-Tyr+Ala-Val-Glu-NH2	S		Ac	Glu	Val	Tyr	Ala	Val	Glu	NH2	Marokhazi et al., 2007
Ac-Glu-Val-Tyr-Leu-Ala-Glu-NH2			Ac-Glu-Val-Tyr+Leu-Ala-Glu-NH2	S		Ac	Glu	Val	Tyr	Leu	Ala	Glu	NH2	Marokhazi et al., 2007
Ac-Glu-Val-Tyr-Leu-Leu-Glu-NH2			Ac-Glu-Val-Tyr+Leu-Leu-Glu-NH2	S		Ac	Glu	Val	Tyr	Leu	Leu	Glu	NH2	Marokhazi et al., 2007
Ac-Glu-Val-Tyr-Leu-Val-Glu-NH2			Ac-Glu-Val-Tyr+Leu-Val-Glu-NH2	S		Ac	Glu	Val	Tyr	Leu	Val	Glu	NH2	Marokhazi et al., 2007
beta-1,3-glucan-binding protein 1	Q9NJ98	1-487	peptide-Cys19+Leu-peptide	P	NT	Ser	Val	Arg	Cys	Leu	Glu	Val	Pro	Felföldi et al., 2009
beta-lipotropin	P01192	26-267	peptide-Gly180+Ala-peptide	N		Glu	Leu	Ala	Gly	Ala	Pro	Pro	Glu	Marokhazi et al., 2007
beta-lipotropin	P01192	26-267	peptide-Gly195+Ala-peptide	N		Pro	Ala	Glu	Gly	Ala	Ala	Ala	Arg	Marokhazi et al., 2007
beta-lipotropin	P01192	26-267	peptide-Gly205+Leu-peptide	N		Leu	Glu	Tyr	Gly	Leu	Val	Ala	Glu	Marokhazi et al., 2007
beta-lipotropin	P01192	26-267	peptide-Ser246+Gln-peptide	N		Ser	Glu	Lys	Ser	Gln	Thr	Pro	Leu	Marokhazi et al., 2007
beta-lipotropin	P01192	26-267	peptide-Thr252+Leu-peptide	N		Pro	Leu	Val	Thr	Leu	Phe	Lys	Asn	Marokhazi et al., 2007
Dabcyl-Glu-Val-Tyr-Ala-Val-Glu-Ser-Edans			Dabcyl-Glu-Val-Tyr+Ala-Val-Glu-Ser-Edans	S		Dab	Glu	Val	Tyr	Ala	Val	Glu	Ser	Marokhazi et al., 2007
Dabcyl-Gly-Leu-Arg-Thr-Gln-Ser-Phe-Ser-Edans			Dabcyl-Gly-Leu-Arg-Thr-Gln-Ser+Phe-Ser-Edans	N		Arg	Thr	Gln	Ser	Phe	Ser	Ens	-	Marokhazi et al., 2007
insulin A chain (oxidized)	P01317	85-105	Gly-Ile-Val-Glu-Gln-Cya-Cya-Ala-Ser-Val-Cya+Ser-Leu-Tyr-Gln-Leu-Glu-Asn-Tyr-Cya-Asn	N		Ala	Ser	Val	Cya	Ser	Leu	Tyr	Gln	Marokhazi et al., 2007
insulin A chain (oxidized)	P01317	85-105	Gly-Ile-Val-Glu-Gln-Cya-Cya-Ala-Ser-Val-Cya-Ser-Leu-Tyr+Gln-Leu-Glu-Asn-Tyr-Cya-Asn	N		Cya	Ser	Leu	Tyr	Gln	Leu	Glu	Asn	Marokhazi et al., 2007
insulin A chain (oxidized)	P01317	85-105	Gly-Ile-Val-Glu-Gln-Cya-Cya-Ala+Ser-Val-Cya-Ser-Leu-Tyr-Gln-Leu-Glu-Asn-Tyr-Cya-Asn	N		Glu	Gln	Cya	Ala	Ser	Val	Cya	Ser	Marokhazi et al., 2007
insulin B-chain (oxidized)	P01317	25-54	Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu+Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala	N		Gly	Ser	His	Leu	Val	Glu	Ala	Leu	Marokhazi et al., 2007
insulin B-chain (oxidized)	P01317	25-54	Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu+Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala	N		His	Leu	Val	Glu	Ala	Leu	Tyr	Leu	Marokhazi et al., 2007
insulin B-chain (oxidized)	P01317	25-54	Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr+Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala	N		Glu	Ala	Leu	Tyr	Leu	Val	Cya	Gly	Marokhazi et al., 2007
scolexin B	O96991	1-279	peptide-Pro21+Asp-peptide	P	NT	Cys	Ala	Ala	Pro	Asp	Pro	Gly	Ala	Felf”ldi et al., 2009
scolexin B	O96991	1-279	peptide-Pro23+Gly-peptide	P	NT	Ala	Pro	Asp	Pro	Gly	Ala	Asn	Asp	Felf”ldi et al., 2009
serine protease-like protein	Q86RS2	1-305	peptide-Ala19+Asp-peptide	P	NT	Phe	Ile	Ala	Ala	Asp	Gln	Gly	Ser	Felföldi et al., 2009