Substrates for peptidase C80.001: RTX self-cleaving toxin

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
multifunctional-autoprocessing repeats-in-toxin {ECO:0000303|PubMed:26185092} Q9KS12 1-4558 peptide-Leu1971+Ser-peptide P NT Leu Glu Ser Leu Ser Ala Val Gln Prochazkova et al., 2009
multifunctional-autoprocessing repeats-in-toxin {ECO:0000303|PubMed:26185092} Q9KS12 1-4558 peptide-Leu2447+Gly-peptide P NT Leu His Ala Leu Gly Glu Thr Ser Shen et al., 2009
multifunctional-autoprocessing repeats-in-toxin {ECO:0000303|PubMed:26185092} Q9KS12 1-4558 peptide-Leu3098+Ser-peptide P NT Leu Asp Ala Leu Ser Gly Asn Glu Shen et al., 2009
multifunctional-autoprocessing repeats-in-toxin {ECO:0000303|PubMed:26185092} Q9KS12 1-4558 peptide-Leu3441+Ala-peptide P NT Lys Glu Ala Leu Ala Asp Gly Lys Shen et al., 2009
RTX toxin RtxA A1EPL5 1-4558 peptide-Leu3441+Ala-peptide P Lys Glu Ala Leu Ala Asp Gly Lys Sheahan et al., 2008 26844