Substrates for peptidase C60.002: sortase B
Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.
| Substrate | Uniprot | Residue range | Cleavage Site | Cleavage type | Evidence | P4 | P3 | P2 | P1 | P1' | P2' | P3' | P4' | Reference | CutDB | MERNUM |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Abz-Lys-Val-Glu-Asn-Pro-Gln-Thr-Asn-Ala-Gly-Thr-Dap(DNP)-NH2 | Peptide-Thr+Asn-Ala-Gly-Thr | S | Asn | Pro | Gln | Thr | Asn | Ala | Gly | Thr | Bentley et al., 2007 | |||||
| iron-regulated surface determinant protein C | Q8KQR1 | 29-227 | peptide-Thr192+Asn-peptide | P | CS | Asn | Pro | Gln | Thr | Asn | Ala | Gly | Thr | Mazmanian et al., 2002 | ||
| lmo2185 protein | Q9KGV9 | 1-569 | peptide-Thr539+Asn-peptide | P | MU | Asn | Ala | Lys | Thr | Asn | Asp | Ser | Ser | Mariscotti et al., 2009 | ||
| lmo2186 protein | Q8Y585 | 1-207 | peptide-Ser177+Ser-peptide | P | MU | Asn | Pro | Lys | Ser | Ser | Asp | Ser | Ser | Mariscotti et al., 2009 | ||
| putative LPXTG-motif cell wall anchor domain protein | Q81L43 | 1-237 | peptide-Thr209+Gly-peptide | P | CS | Asn | Pro | Lys | Thr | Gly | Asp | Glu | Ala | Gaspar et al., 2005 |
