Substrates for peptidase C39.007: lacticin 481 processing peptidase (Lactococcus lactis)

Summary Alignment Sequences Sequence features Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
lantibiotic lacticin-481 P36499 1-51 peptide-Ala24+Lys-peptide P Ile Leu Gly Ala Lys Gly Gly Ser Furgerson-Ihnken et al., 2008
Lantibiotic lacticin-481 (Ala24Gly) mutant peptide-Gly24+Lys-peptide N Ile Leu Gly Gly Lys Gly Gly Ser Furgerson-Ihnken et al., 2008
Lantibiotic lacticin-481 (Glu17Pro) mutant peptide-Gly23+Ala-peptide N Leu Ile Leu Gly Ala Lys Gly Gly Furgerson-Ihnken et al., 2008
Lantibiotic lacticin-481 (Gly23Val) mutant peptide-Ala24+Lys-peptide N Ile Leu Val Ala Lys Gly Gly Ser Furgerson-Ihnken et al., 2008
Lantibiotic lacticin-481 (Gly27His) mutant peptide-Ala24+Lys-peptide N Ile Leu Gly Ala Lys Gly His Ser Furgerson-Ihnken et al., 2008
Lantibiotic lacticin-481 (Gly27Ile) mutant peptide-Ala24+Lys-peptide N Ile Leu Gly Ala Lys Gly Ile Ser Furgerson-Ihnken et al., 2008
Lantibiotic lacticin-481 (Ile21Pro) mutant peptide-Ala24+Lys-peptide N Pro Leu Gly Ala Lys Gly Gly Ser Furgerson-Ihnken et al., 2008
Lantibiotic lacticin-481 (Lys25Ala) mutant peptide-Ala24+Ala-peptide N Ile Leu Gly Ala Ala Gly Gly Ser Furgerson-Ihnken et al., 2008
Lantibiotic lacticin-481 (Lys25Lys-Ala-Ala-Ala) mutant peptide-Gly23+Ala-peptide N Leu Ile Leu Gly Ala Lys Ala Ala Furgerson-Ihnken et al., 2008
Lantibiotic lacticin-481 (Lys25Lys-Ala-Ala-Ala) mutant peptide-Ala24+Lys-peptide N Ile Leu Gly Ala Lys Ala Ala Ala Furgerson-Ihnken et al., 2008
Lantibiotic lacticin-481 (Lys25Lys-Ala-Ala-Ala) mutant peptide-Gly29+Gly-peptide N Ala Ala Ala Gly Gly Ser Gly Val Furgerson-Ihnken et al., 2008
Lantibiotic lacticin-481 (Lys25Lys-Ala-Ala-Ala) mutant peptide-Gly30+Ser-peptide N Ala Ala Gly Gly Ser Gly Val Ile Furgerson-Ihnken et al., 2008
Lantibiotic mutacin-2 (MutA) chimera with lantibiotic lacticin-481 propeptide peptide-Ala24+Asn-peptide N Ile Leu Gly Ala Asn Arg Trp Trp Furgerson-Ihnken et al., 2008
Lantibiotic nukacin (NukA) chimera with lantibiotic lacticin-481 propeptide peptide-Ala24+Lys-peptide N Ile Leu Gly Ala Lys Lys Lys Ser Furgerson-Ihnken et al., 2008
Lantibiotic subtilin (SpaS) chimera with lantibiotic lacticin-481 propeptide peptide-Ala24+Trp-peptide N Ile Leu Gly Ala Trp Lys Ser Glu Furgerson-Ihnken et al., 2008
Ruminococcin-A (RumA) chimera with lantibiotic lacticin-481 propeptide peptide-Ala24+Gly-peptide N Ile Leu Gly Ala Gly Asn Gly Val Furgerson-Ihnken et al., 2008