Substrates for peptidase C24.003: sapovirus 3C-like peptidase

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
polyprotein	Q6XDK8		peptide-Glu1055+Ala-peptide	P	Tyr	Asp	Glu	Glu	Ala	Pro	Thr	Pro	Oka et al., 2005
polyprotein	Q672I1	61-76	peptide-Glu68+Gly-peptide	P	Phe	Val	Glu	Glu	Gly	Leu	Leu	Asp	Robel et al., 2008
polyprotein	Q672I1	1714-1730	peptide-Glu1721+Gly-peptide	P	Phe	Glu	Met	Glu	Gly	Asn	Gly	Ser	Robel et al., 2008
polyprotein	Q672I1	658-672	peptide-Gln665+Ala-peptide	P	Phe	Lys	Glu	Gln	Ala	Gly	Pro	Leu	Robel et al., 2008
polyprotein	Q672I1	317-332	peptide-Gln324+Gly-peptide	P	Phe	Thr	Ala	Gln	Gly	Pro	Thr	Asp	Robel et al., 2008
SV14 peptide			PQQHFEEE+APTAIVEFT	S	Phe	Glu	Glu	Glu	Ala	Pro	Thr	Ala	Robel et al., 2008
SV17 peptide			VKTTFTEQ+GPTDLGWA	S	Phe	Thr	Glu	Gln	Gly	Pro	Thr	Asp	Robel et al., 2008
SV18 peptide			VKTTFTEQ+GNTDLGWA	S	Phe	Thr	Glu	Gln	Gly	Asn	Thr	Asp	Robel et al., 2008
SV19 peptide			DGYTFVEE+PLLDMFGT	S	Phe	Val	Glu	Glu	Pro	Leu	Leu	Asp	Robel et al., 2008
SV20 peptide			DGYTFVEE+KLLDMFGT	S	Phe	Val	Glu	Glu	Lys	Leu	Leu	Asp	Robel et al., 2008