Substrates for peptidase C24.002: feline calicivirus 3C-like peptidase

Summary Alignment Sequences Sequence features Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
Genome polyprotein	Q66914	942-1761	peptide-Glu960+Ala-peptide	P	NT	Pro	Lys	Ser	Glu	Ala	Lys	Gly	Lys	Sosnovtseva et al., 1999
Genome polyprotein	Q66914	942-1761	peptide-Glu1071+Ser-peptide	P	NT	Phe	Ala	Glu	Glu	Ser	Gly	Pro	Gly	Sosnovtseva et al., 1999
Genome polyprotein	Q66914	942-1761	peptide-Glu1345+Thr-peptide	P	NT	Ile	Ser	Ser	Glu	Thr	Ser	Met	Leu	Sosnovtseva et al., 1999
Genome polyprotein	Q66914	942-1761	peptide-Glu1419+Gly-peptide	P	NT	Lys	Val	Ala	Glu	Gly	Lys	Arg	Arg	Sosnovtseva et al., 1999
Genome polyprotein	Q66914	1-1763	peptide-Glu46+Ala-peptide	P	NT	Ile	Arg	Ala	Glu	Ala	Cys	Pro	Ser	Sosnovtsev et al., 2002
Genome polyprotein	Q66914	1-1763	peptide-Glu331+Asp-peptide	P	NT	Phe	Arg	Ser	Glu	Asp	Val	Ala	Asn	Sosnovtsev et al., 2002
Genome polyprotein	Q66914	1-1763	peptide-Glu685+Asn-peptide	P	NT	Phe	Glu	Ala	Glu	Asn	Gly	His	Ser	Sosnovtsev et al., 2002
Polyadenylate-binding protein 1	P11940	1-636	Peptide-Gln440+Gly-Peptide	N	MU	Trp	Thr	Ala	Gln	Gly	Ala	Arg	Pro	Kuyumcu-Martinez et al., 2004