Substrates for peptidase C21.001: tymovirus peptidase

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
engineered tymovirus 206 kDa polyprotein peptide-Gly1259+Ala-peptide P Leu Asn Gly Gly Ala Ala CPe -
RNA replicase polyprotein P10358 1-1844 peptide-Ala1259+Thr-peptide P Leu Asn Gly Ala Thr Pro Ser Ala 16280
RNA replicase polyprotein P10358 1-1844 peptide-Ser879+Gln-peptide P MU Leu Leu Gly Ser Gln Pro Ser Ala Jakubiec et al., 2007