Substrates for peptidase C16.010: human coronavirus 229E papain-like peptidase 2

Summary Alignment Sequences Sequence features Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
replicase polyprotein 1ab	P0C6X1	1-6758	peptide-Ala2484+Gly-peptide	P	MU	Lys	Gln	Gly	Ala	Gly	Asp	Ala	Gly
replicase polyprotein 1ab	P0C6X5	893-904	Phe-Thr-Lys-Leu-Ala-Gly+Gly-Lys-Ile-Ser-Phe-Ser	P	MS	Lys	Leu	Ala	Gly	Gly	Lys	Ile	Ser	Chen et al., 2007
replicase polyprotein 1ab	P0C6X5	2457-2468	Val-Ala-Lys-Gln-Gly-Ala+Gly-Phe-Lys-Arg-Thr-Tyr	P	MS	Lys	Gln	Gly	Ala	Gly	Phe	Lys	Arg	Chen et al., 2007