Substrates for peptidase C16.002: human coronavirus 229E papain-like peptidase 1

Summary Alignment Sequences Sequence features Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
replicase polyprotein 1ab	P0C6X1	1-6758	peptide-Ala2484+Gly-peptide	N		Lys	Gln	Gly	Ala	Gly	Asp	Ala	Gly		16261
replicase polyprotein 1ab	P0C6X1	1-6758	peptide-Gly111+Asn-peptide	P	MU	Arg	Gly	Gly	Gly	Asn	Val	Thr	Tyr		16262
replicase polyprotein 1ab	P0C6X1	1-6758	peptide-Gly897+Gly-peptide	P	MU	Lys	Ala	Ala	Gly	Gly	Lys	Val	Ser	Ziebuhr et al., 2001	16263