Substrates for peptidase C16.001: murine hepatitis coronavirus papain-like peptidase 1

Summary Alignment Sequences Sequence features Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
replicase polyprotein 1ab	P0C6Y0	1-7180	peptide-Gly247+Val-peptide	P		Gly	Tyr	Arg	Gly	Val	Lys	Pro	Ile	Kanjanahaluethai & Baker, 2004	16260
replicase polyprotein 1ab	P0C6Y0	1-7180	peptide-Ala832+Gly-peptide	P		Phe	Pro	Cys	Ala	Gly	Lys	Lys	Val	Kanjanahaluethai & Baker, 2004	16259
replicase polyprotein 1ab	P0C6X9	1-7176	peptide-Gly247+Val-peptide	N	MU	Gly	Tyr	Arg	Gly	Val	Lys	Pro	Ile
replicase polyprotein 1ab	P0C6X9	1-7176	peptide-Ala832+Gly-peptide	N	MU	Phe	Pro	Cys	Ala	Gly	Lys	Lys	Val