Substrates for peptidase C15.012: pyroglutamyl-peptidase I (Trypanosoma-type)

Summary Alignment Tree Sequences Sequence features Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
Glp-NHMec Glp+NHMec S - - - Glp AMC - - - Morty et al., 2006
Glp-NHPhNO2 Glp+NHPhNO2 S - - - Glp NAN - - - Morty et al., 2006
gonadotropin-releasing hormone Glp+His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly N - - - Glp His Trp Ser Tyr Morty et al., 2006
thyrotropin-releasing hormone Glp+His-Pro-NH2 N - - - Glp His Pro NH2 - Morty et al., 2006