Substrates for peptidase C14.040: caspase Dredd

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
Ile-Glu-Thr-Asp-NHPhNO2			Ile-Glu-Thr-Asp+NHPhNO2	S		Ile	Glu	Thr	Asp	NAN	-	-	-	Cooper et al., 2007
Immune deficiency	Q7K4Z4	1-273	Peptide-Asp30+Ala-Peptide	P	MU	Leu	Glu	Lys	Asp	Ala	Ala	Pro	Val	Paquette et al., 2010
Tyr-Val-Ala-Asp-NHPhNO2			Tyr-Val-Ala-Asp+NHPhNO2	S		Tyr	Val	Ala	Asp	NAN	-	-	-	Cooper et al., 2007
Val-Asp-Val-Ala-Asp-NHPhNO2			Val-Asp-Val-Ala-Asp+NHPhNO2	S		Asp	Val	Ala	Asp	NAN	-	-	-	Cooper et al., 2007