Substrates for peptidase C14.038: caspase-15

Summary Alignment Tree Sequences Sequence features Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
Caspase-15	Q3T2L1	1-368	Peptide-Asp270+Asp-Peptide	P	MU	Val	Glu	Thr	Asp	Asp	Glu	Pro	Met	Eckhart et al., 2006
caspase-15 precursor	Q3T2L1	1-368	peptide-Asp277+Asp-peptide	P		Met	Asp	Ser	Asp	Asp	Val	Ser	Glu	Eckhart et al., 2005	20363
Ile-Glu-Thr-Asp-NHPhNO2			Ile-Glu-Thr-Asp+NHPhNO2	S		Ile	Glu	Thr	Asp	NAN	-	-	-	Eckhart et al., 2005
Trp-Glu-His-Asp-NHPhNO2			Trp-Glu-His-Asp+NHPhNO2	S		Trp	Glu	His	Asp	NAN	-	-	-	Eckhart et al., 2005
Tyr-Val-Ala-Asp-NHPhNO2			Tyr-Val-Ala-Asp+NHPhNO2	S		Tyr	Val	Ala	Asp	NAN	-	-	-	Eckhart et al., 2005