Substrates for peptidase C14.015: caspase (insect 1)

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
armadillo segment polarity protein	P18824	1-843	peptide-Asp88+Asp-peptide	P	MU	Asp	Gln	Val	Asp	Asp	Met	Asn	Gln	Kessler et al., 2009
bicaudal, isoform A	Q7KM15	1-169	peptide-Asp141+Val-peptide	P	MU	Gly	Asp	Asp	Asp	Val	Pro	Asp	Leu	Creagh et al., 2009
caspase-1 precursor	P89116	1-299	peptide-Asp28+Ala-peptide	P		Asp	Glu	Gly	Asp	Ala	Leu	Gly	Ser	Ahmad et al., 1997	19969
caspase-1 precursor	P89116	1-299	peptide-Asp184+Gly-peptide	P		Asp	Arg	Leu	Asp	Gly	Gly	Ile	Thr	Ahmad et al., 1997	19970
caspase-1 precursor	P89116	1-299	peptide-Asp195+Gly-peptide	P		Thr	Glu	Thr	Asp	Gly	Ser	Pro	Ser	Ahmad et al., 1997	19971
DIAPI	Q24306	1-438	peptide-Asp20+Asn-peptide	P		Asp	Gln	Val	Asp	Asn	Asn	Thr	Asn	Muro et al., 2005	16254
Early 35 kDa protein	P08160	1-299	peptide-Asp87+Gly-peptide	N		Asp	Gln	Met	Asp	Gly	Phe	His	Asp	Ahmad et al., 1997	19972
HLH106 helix loop helix protein 106, isoform A	Q9VW37	1-1113	peptide-Asp386+Ala-peptide	P	MU	Phe	Thr	Thr	Asp	Ala	Gly	Leu	Thr	Amarneh et al., 2009	24227