Substrates for peptidase C02.014: calpain A

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
calpain-A Q11002 1-828 peptide-Lys54+Asn-peptide P NT Pro Ser Ile Lys Asn Met Arg Val Jekely & Friedrich, 1999
DABCYL-TPLKSPPPSPR-EDANS Dabcyl-Thr-Pro-Leu-Lys+Ser-Pro-Pro-Pro-Ser-Pro-Arg-EDANS S Thr Pro Leu Lys Ser Pro Pro Pro Tompa et al., 2004
NF-kappa-B inhibitor cactus -eGFP fusion Q03017 1-500 Peptide-Lys148+His-Peptide P MS Met Arg Leu Lys His Ser Ala Asp Fontenele et al., 2013