Substrates for peptidase C01.166: SmCL1 peptidase (Schistosoma mansoni and similar)

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Cleavage Site	Cleavage type	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
Boc-Phe-Val-Arg-NHMec	Boc-Phe-Val-Arg+NHMec	S	Boc	Phe	Val	Arg	AMC	-	-	-	Brady et al., 2000
Boc-Val-Leu-Lys-NHMec	Boc-Val-Leu-Lys+NHMec	S	Boc	Val	Leu	Lys	AMC	-	-	-	Brady et al., 2000
H-Leu-Val-Tyr-NHMec	H-Leu-Val-Tyr+NHMec	S	-	Leu	Val	Tyr	AMC	-	-	-	Brady et al., 2000
Suc-Leu-Tyr-NHMec	Suc-Leu-Tyr+NHMec	S	-	Suc	Leu	Tyr	AMC	-	-	-	Brady et al., 2000
Tos-Gly-Pro-Arg-NHMec	Tos-Gly-Pro-Arg+NHMec	S	Tos	Gly	Pro	Arg	AMC	-	-	-	Brady et al., 2000
Z-Leu-Arg-NHMec	Z-Leu-Arg+NHMec	S	-	Z	Leu	Arg	AMC	-	-	-	Brady et al., 2000
Z-Phe-Arg-NHMec	Z-Phe-Arg+NHMec	S	-	Z	Phe	Arg	AMC	-	-	-	Brady et al., 2000
Z-Phe-Val-Arg-NHMec	Z-Phe-Val-Arg+NHMec	S	Z	Phe	Val	Arg	AMC	-	-	-	Brady et al., 1999
Z-Val-Leu-Arg-NHMec	Z-Val-Leu-Arg+NHMec	S	Z	Val	Leu	Arg	AMC	-	-	-	Brady et al., 2000