Substrates for peptidase C01.115: fascipain B

Summary Alignment Tree Sequences Sequence features Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
Abz-Ala-Phe-Arg-Ala-Ala-Gln-Lys(Dnp) OH			Abz-Ala-Phe-Arg+Ala-Ala-Gln-Lys(Dnp)	S	Abz	Ala	Phe	Arg	Ala	Ala	Gln	Lyd	Beckham et al., 2009
Boc-Asp-Pro-Arg-NHMec			Boc-Asp-Pro-Arg+NHMec	S	Boc	Asp	Pro	Arg	AMC	-	-	-	Beckham et al., 2009
Boc-Val-Pro-Arg-NHMec			Boc-Val-Pro-Arg+NHMec	S	Boc	Val	Pro	Arg	AMC	-	-	-	Beckham et al., 2009
cathepsin B	Q86MW7	1-339	peptide-Leu60+Gly-peptide	P	Lys	Leu	His	Leu	Gly	Ala	Leu	Ser	Beckham et al., 2006
cathepsin B	Q86MW7	1-339	peptide-Ser82+Lys-peptide	P	His	Asp	Ile	Ser	Lys	Asn	Asp	Leu	Beckham et al., 2006
D-Val-Leu-Arg-AMC			D-Val-Leu-Arg+AMC	S	-	Dva	Leu	Arg	AMC	-	-	-	Beckham et al., 2009
Tos-Gly-Pro-Arg-NHMec			Tos-Gly-Pro-Arg+NHMec	S	Tos	Gly	Pro	Arg	AMC	-	-	-	Beckham et al., 2009
Z-Arg-Arg-AMC			Z-Arg-Arg+AMC	S	-	Z	Arg	Arg	AMC	-	-	-	Beckham et al., 2009
Z-Phe-Arg-NHMec			Z-Phe-Arg+NHMec	S	-	Z	Phe	Arg	AMC	-	-	-	Beckham et al., 2006
Z-Val-Ile-Arg-NHMec			Z-Val-Ile-Arg+NHMec	S	Z	Val	Ile	Arg	AMC	-	-	-	Beckham et al., 2009