Substrates for peptidase C01.007: actinidin

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
Ac-Phe-Gly-NHPhNO2			Ac-Phe-Gly+NHPhNO2	S		-	Ac	Phe	Gly	NAN	-	-	-	Watts & Brocklehurst, 2004
Bz-Arg-NHPhNO2 (BAPNA)			Bz-Arg+NHPhNO2	S		-	-	Bz	Arg	NAN	-	-	-	Watts & Brocklehurst, 2004
Collagen alpha-1(I) chain precursor	P02457	23-1453	Peptide-Gly163+Val-Peptide	N	NT	Lys	Ser	Ala	Gly	Val	Ala	Val	Pro	Kunii et al., 2010
Collagen alpha-1(I) chain precursor	P02457	23-1453	Peptide-Ala165+Val-Peptide	N	NT	Ala	Gly	Val	Ala	Val	Pro	Gly	Pro	Kunii et al., 2010
Collagen alpha-1(I) chain precursor	P02457	23-1453	Peptide-Gly1183+Gly-Peptide	N	MS	Pro	Pro	Ser	Gly	Gly	Phe	Asp	Leu	Kunii et al., 2010
Collagen alpha-2(I) chain	P02467	23-1362	Peptide-Ala85+Asp-Peptide	N	NT	Ser	Lys	Ala	Ala	Asp	Phe	Gly	Pro	Kunii et al., 2010
Collagen alpha-2(I) chain	P02467	23-1362	Peptide-Phe87+Gly-Peptide	N	NT	Ala	Ala	Asp	Phe	Gly	Pro	Gly	Pro	Kunii et al., 2010
Collagen alpha-2(I) chain	P02467	23-1362	Peptide-Gly93+Leu-Peptide	N	NT	Gly	Pro	Met	Gly	Leu	Met	Gly	Pro	Kunii et al., 2010
Collagen alpha-2(I) chain	P02467	23-1362	Peptide-Glu1107+Val-Peptide	N	MS	Gly	Gly	Tyr	Glu	Val	Gly	Phe	Asp	Kunii et al., 2010
insulin B-chain (oxidized)	P01317	25-54	Phe-Val-Asn+Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala	N		-	Phe	Val	Asn	Gln	His	Leu	Cya	Lynn, 1983
insulin B-chain (oxidized)	P01317	25-54	Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His+Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala	N		Cya	Gly	Ser	His	Leu	Val	Glu	Ala	Lynn, 1983
insulin B-chain (oxidized)	P01317	25-54	Phe-Val-Asn-Gln-His-Leu-Cya-Gly+Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala	N		His	Leu	Cya	Gly	Ser	His	Leu	Val	Lynn, 1983
insulin B-chain (oxidized)	P01317	25-54	Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val+Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala	N		Ser	His	Leu	Val	Glu	Ala	Leu	Tyr	Lynn, 1983
insulin B-chain (oxidized)	P01317	25-54	Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr+Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala	N		Glu	Ala	Leu	Tyr	Leu	Val	Cya	Gly	Lynn, 1983
insulin B-chain (oxidized)	P01317	25-54	Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg+Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala	N		Cya	Gly	Glu	Arg	Gly	Phe	Phe	Tyr	Lynn, 1983
insulin B-chain (oxidized)	P01317	25-54	Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe+Tyr-Thr-Pro-Lys-Ala	N		Arg	Gly	Phe	Phe	Tyr	Thr	Pro	Lys	Lynn, 1983
insulin B-chain (oxidized)	P01317	25-54	Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr+Thr-Pro-Lys-Ala	N		Gly	Phe	Phe	Tyr	Thr	Pro	Lys	Ala	Lynn, 1983
Tos-Gln-OPhNO2			Tos-Gln+OPhNO2	S		-	-	Tos	Gln	ONA	-	-	-	Watts & Brocklehurst, 2004
Z-Lys-OPhNO2			Z-Lys+OPhNO2	S		-	-	Z	Lys	ONA	-	-	-	Watts & Brocklehurst, 2004