Substrates for peptidase A09.001: spumapepsin

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
gag polyprotein P14349 306-316 Pro-Ile-Gln-His-Ile-Arg+Ser-Val-Thr-Gly-Glu P NT Gln His Ile Arg Ser Val Thr Gly Pfrepper et al., 1999
gag polyprotein P14349 333-359 peptide-Phe339+Pro-peptide P NT Asp Gly Val Phe Pro Val Thr Thr Pfrepper et al., 1999
gag polyprotein P14349 333-359 peptide-Asn352+Ala-peptide P NT Arg Ile Ile Asn Ala Ile Leu Gly Pfrepper et al., 1999
gag polyprotein P14349 618-625 Arg-Ala-Val-Asn+Thr-Val-Thr-Gln P NT Arg Ala Val Asn Thr Val Thr Gln Pfrepper et al., 1999 16037
Pro-Arg-Ala-Val-Asn-Thr-Val-Thr-Gln-Arg Pro-Arg-Ala-Val-Asn+Thr-Val-Thr-Gln-Arg N Arg Ala Val Asn Thr Val Thr Gln
pro-Pol polyprotein P14350 1-1143 peptide-Asn774+Gln-peptide P His Trp Glu Asn Gln Val Gly His Pfrepper et al., 1998 16036
pro-Pol polyprotein P14350 1-1143 peptide-Phe399+Tyr-peptide P Glu Gly Val Phe Tyr Thr Asp Gly Pfrepper et al., 1998 16039
pro-Pol polyprotein P14350 1-1143 peptide-Asn554+Cys-peptide P Tyr Val Val Asn Cys Asn Thr Lys Pfrepper et al., 1998 16038
transposon Ty3-G Gag-Pol polyprotein Q99315 2-1547 peptide-Tyr734+Thr-peptide P Arg Ala Val Tyr Thr Ile Thr Pro Fenyofalvi et al., 1999 16040
ty1 transposon gag/pol polyprotein P47098 1-1755 peptide-Asn582+Asn-peptide P Pro Thr Ile Asn Asn Val His Thr Fenyofalvi et al., 1999 16042
ty1 transposon gag/pol polyprotein P47098 1-1755 peptide-Ala1217+Ala-peptide P His Leu Ile Ala Ala Val Lys Ala Fenyofalvi et al., 1999 16041