Substrates for peptidase A02.016: intracisternal A-particle retropepsin

Summary Alignment Tree Sequences Sequence features Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
Ala-His-Gln-Val-Tyr+Nph-Val-Arg-Lys-Ala			Ala-His-Gln-Val-Tyr-Nph-Val-Arg-Lys-Ala	S	His	Gln	Val	Tyr	Nph	Val	Arg	Lys	Konvalinka & Krausslich, 2004
Asp-Ser-Ala-Tyr-Nph-Val-Val-Ser			Asp-Ser-Ala-Tyr+Nph-Val-Val-Ser	S	Asp	Ser	Ala	Tyr	Nph	Val	Val	Ser	Konvalinka & Krausslich, 2004
Lys-Ala-Arg-Val-Tyr-Nph-Glu-Ala-Nle-NH2			Lys-Ala-Arg-Val-Tyr+Nph-Glu-Ala-Nle-NH2	S	Ala	Arg	Val	Tyr	Nph	Glu	Ala	Nle	Konvalinka & Krausslich, 2004
MIA14 polyprotein	P11365	1-827	peptide-Tyr670+Leu-peptide	P	Asp	Ser	Ala	Tyr	Leu	Val	Val	Ser	Konvalinka & Krausslich, 2004	16008
MIA14 polyprotein	P11365	1-827	peptide-Leu771+Ile-peptide	P	His	Leu	Gly	Leu	Ile	Leu	Ser	Asn	Konvalinka & Krausslich, 2004	16006
MIA14 polyprotein	P11365	1-827	peptide-Ile772+Leu-peptide	P	Leu	Gly	Leu	Ile	Leu	Ser	Asn	Glu	Konvalinka & Krausslich, 2004	16005
MIA14 polyprotein	P11365	1-827	peptide-Met791+Ala-peptide	P	Lys	Asn	Ile	Met	Ala	Lys	Met	Gly	Konvalinka & Krausslich, 2004	16007