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Peptidase

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Structure for peptidase homologue S60.970: lactotransferrin precursor, domain 2

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature

 

PDB Organism Resolution Comment
1IEJ_A Gallus gallus 1.65 Å N-terminal lobe, holo form
Catalytic residues are shown in ball-and-stick representation: Ser275 in orange and Lys90 in purple. The structural ferric ion is shown as a red CPK sphere.
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TERTIARY STRUCTURE DATA
Comment Resolution PDB PDBe SCOP CATH PDBSum Proteopedia Reference
Bos taurus
mature  peptidase 2.80 Å 1BLF 1BLF 1BLF 1BLF 1BLF 1BLF Moore et al., 1997
mature  peptidase 0.00 Å 1LFC 1LFC 1LFC 1LFC 1LFC 1LFC Hwang et al., 1998
proteolytically generated functional monoferric C-terminal lobe 1.90 Å 1NKX 1NKX 1NKX 1NKX 1NKX 1NKX Sharma et al., 2003
zinc saturated C-terminal lobe 2.06 Å 1SDX 1SDX 1SDX 1SDX 1SDX 1SDX Jabeen et al., 2005
mature  peptidase 0.00 Å 1Y58 1Y58 1Y58 1Y58 1Y58 1Y58 Nguyen et al., 2005
C-terminal lobe; complex with indomethacin 2.20 Å 2ALT 2ALT 2ALT 2ALT 2ALT 2ALT
C-terminal lobe; complex with tetrasaccharide 2.09 Å 2ALU 2ALU 2ALU 2ALU 2ALU 2ALU
C-terminal lobe; complex with N-acetyl galactosamine 1.86 Å 2AYS 2AYS 2AYS 2AYS 2AYS 2AYS
C-terminal lobe; complex with maltose 1.50 Å 2B65 2B65 2B65 2B65 2B65 2B65
C-terminal lobe; complex with diclofenac 1.40 Å 2B6D 2B6D 2B6D 2B6D 2B6D 2B6D
C-terminal lobe; complex with adenosine 2.40 Å 2DOJ 2DOJ 2DOJ 2DOJ 2DOJ 2DOJ
C-terminal lobe; complex with trisaccharide 2.50 Å 2DP8 2DP8 2DP8 2DP8 2DP8 2DP8
C-terminal lobe; complex with galactose 2.70 Å 2DQV 2DQV 2DQV 2DQV 2DQV 2DQV
C-terminal lobe; complex with mannose 2.80 Å 2DS9 2DS9 2DS9 2DS9 2DS9 2DS9
C-terminal lobe; complex with xylose 2.80 Å 2DSF 2DSF 2DSF 2DSF 2DSF 2DSF
C-terminal lobe; complex with sucrose 3.00 Å 2DVC 2DVC 2DVC 2DVC 2DVC 2DVC
C-terminal lobe; complex with fucose 2.07 Å 2DWA 2DWA 2DWA 2DWA 2DWA 2DWA
C-terminal lobe; complex with N-acetylglucosamine 2.80 Å 2DWH 2DWH 2DWH 2DWH 2DWH 2DWH
C-terminal lobe; complex with cellobiose 2.20 Å 2DWI 2DWI 2DWI 2DWI 2DWI 2DWI
C-terminal lobe; complex with raffinose 2.30 Å 2DWJ 2DWJ 2DWJ 2DWJ 2DWJ 2DWJ
C-terminal lobe; complex with sorbitol 2.85 Å 2DXR 2DXR 2DXR 2DXR 2DXR 2DXR
C-terminal lobe; complex with trehalose 2.03 Å 2DXY 2DXY 2DXY 2DXY 2DXY 2DXY
structure of the complex of lactoferrin c-lobe with melibiose at 2.0 a resolution 2.00 Å 2DYX 2DYX 2DYX 2DYX 2DYX 2DYX
C-terminal lobe; complex with rhamnose 2.15 Å 2E0S 2E0S 2E0S 2E0S 2E0S 2E0S
C-terminal lobe; complex with arabinose 2.70 Å 2E1S 2E1S 2E1S 2E1S 2E1S 2E1S
C-terminal lobe; complex with a pentasaccharide 2.38 Å 2FA7 2FA7 2FA7 2FA7 2FA7 2FA7
C-terminal lobe; complex with acetyl salicylic acid 2.00 Å 2G5J 2G5J 2G5J 2G5J 2G5J 2G5J
C-terminal lobe; complex with methyl alpha-d-mannopyranoside 1.90 Å 2G93 2G93 2G93 2G93 2G93 2G93
C-terminal lobe; complex with lactose 2.55 Å 2H4I 2H4I 2H4I 2H4I 2H4I 2H4I
C-terminal lobe; complex with glucose 2.80 Å 2HCA 2HCA 2HCA 2HCA 2HCA 2HCA
mature  peptidase 0.00 Å 2MD1 2MD1 2MD1 2MD1 2MD1 2MD1 Ghosh et al., 2014
mature  peptidase 0.00 Å 2MD2 2MD2 2MD2 2MD2 2MD2 2MD2 Ghosh et al., 2014
mature  peptidase 0.00 Å 2MD3 2MD3 2MD3 2MD3 2MD3 2MD3 Ghosh et al., 2014
mature  peptidase 0.00 Å 2MD4 2MD4 2MD4 2MD4 2MD4 2MD4 Ghosh et al., 2014
C-terminal lobe; complex with atenolol 2.25 Å 2NUV 2NUV 2NUV 2NUV 2NUV 2NUV
C-terminal lobe; complex with disaccharide 2.25 Å 2NWJ 2NWJ 2NWJ 2NWJ 2NWJ 2NWJ
C-terminal lobe; complex with disaccharide 1.97 Å 2O1L 2O1L 2O1L 2O1L 2O1L 2O1L
C-terminal lobe; complex with fructose 3.00 Å 2O51 2O51 2O51 2O51 2O51 2O51
C-terminal lobe; complex with N-(4-hydroxyphenyl) acetamide 2.38 Å 2OCU 2OCU 2OCU 2OCU 2OCU 2OCU
C-terminal lobe; complex with O-alpha-D-glucopyranosyl-(1 3)- alpha-d-fructofuranosyl- (2 1)- alpha-D-glucopyranoside 1.93 Å 2P1S 2P1S 2P1S 2P1S 2P1S 2P1S
C-terminal lobe; complex with ribose 2.50 Å 2PX1 2PX1 2PX1 2PX1 2PX1 2PX1
C-terminal lobe; complex with mannitol and mannose 2.71 Å 2Q8J 2Q8J 2Q8J 2Q8J 2Q8J 2Q8J
C-lobe; complex with amygdalin 2.30 Å 2QJE 2QJE 2QJE 2QJE 2QJE 2QJE
C-lobe; complex with inositol 2.07 Å 2R71 2R71 2R71 2R71 2R71 2R71
ligand recognition in c-lobe: the crystal structure of the complex of lactoferrin c-lobe with nicotinamide at 2.5 a resolution 2.55 Å 2R9J 2R9J 2R9J 2R9J 2R9J 2R9J
C-terminal lobe; complex with parecoxib 2.90 Å 2ZMB 2ZMB 2ZMB 2ZMB 2ZMB 2ZMB
mature  peptidase 2.25 Å 3CFL 3CFL 3CFL 3CFL 3CFL 3CFL
C-lobe; complex with vitamin B3 (niacin) 2.40 Å 3CI8 3CI8 3CI8 3CI8 3CI8 3CI8
C-lobe; complex with 2-chromenone 2.60 Å 3CRB 3CRB 3CRB 3CRB 3CRB 3CRB
C-lobe; complex with nimesulide 2.70 Å 3E9X 3E9X 3E9X 3E9X 3E9X 3E9X
structure of the complex of c-terminal half (c-lobe) of bovine lactoferrin with alpha-methyl-4-(2-methylpropyl) benzene acetic acid 2.29 Å 3FKX 3FKX 3FKX 3FKX 3FKX 3FKX
mature  peptidase 2.00 Å 3IAZ 3IAZ 3IAZ 3IAZ 3IAZ 3IAZ Mir et al., 2009
mature  peptidase 1.40 Å 3IB0 3IB0 3IB0 3IB0 3IB0 3IB0 Mir et al., 2009
mature  peptidase 2.20 Å 3IB1 3IB1 3IB1 3IB1 3IB1 3IB1 Mir et al., 2009
mature  peptidase 2.29 Å 3IB2 3IB2 3IB2 3IB2 3IB2 3IB2 Mir et al., 2009
mature  peptidase 1.91 Å 3K0V 3K0V 3K0V 3K0V 3K0V 3K0V Mir et al., 2010
mature  peptidase 1.91 Å 3KJ7 3KJ7 3KJ7 3KJ7 3KJ7 3KJ7 Mir et al., 2010
mature  peptidase 2.38 Å 3MJN 3MJN 3MJN 3MJN 3MJN 3MJN
mature  peptidase 2.68 Å 3O97 3O97 3O97 3O97 3O97 3O97
mature  peptidase 2.00 Å 3RGY 3RGY 3RGY 3RGY 3RGY 3RGY
mature  peptidase 2.10 Å 3SDF 3SDF 3SDF 3SDF 3SDF 3SDF
mature  peptidase 1.70 Å 3TAJ 3TAJ 3TAJ 3TAJ 3TAJ 3TAJ
mature  peptidase 1.38 Å 3TOD 3TOD 3TOD 3TOD 3TOD 3TOD
mature  peptidase 2.27 Å 3TTR 3TTR 3TTR 3TTR 3TTR 3TTR
mature  peptidase 2.50 Å 3TUS 3TUS 3TUS 3TUS 3TUS 3TUS
mature  peptidase 2.20 Å 3U72 3U72 3U72 3U72 3U72 3U72
mature  peptidase 1.97 Å 3U8Q 3U8Q 3U8Q 3U8Q 3U8Q 3U8Q
mature  peptidase 1.87 Å 3UGW 3UGW 3UGW 3UGW 3UGW 3UGW
mature  peptidase 1.98 Å 3UK4 3UK4 3UK4 3UK4 3UK4 3UK4
mature  peptidase 2.40 Å 3USD 3USD 3USD 3USD 3USD 3USD
mature  peptidase 1.44 Å 3V5A 3V5A 3V5A 3V5A 3V5A 3V5A
mature  peptidase 1.46 Å 3VDF 3VDF 3VDF 3VDF 3VDF 3VDF
mature  peptidase 1.80 Å 4DIG 4DIG 4DIG 4DIG 4DIG 4DIG
mature  peptidase 1.46 Å 4DXU 4DXU 4DXU 4DXU 4DXU 4DXU
mature  peptidase 1.80 Å 4FIM 4FIM 4FIM 4FIM 4FIM 4FIM
mature  peptidase 1.68 Å 4FJP 4FJP 4FJP 4FJP 4FJP 4FJP
mature  peptidase 1.58 Å 4FOR 4FOR 4FOR 4FOR 4FOR 4FOR
mature  peptidase 1.90 Å 4G2Z 4G2Z 4G2Z 4G2Z 4G2Z 4G2Z
mature  peptidase 1.98 Å 4G77 4G77 4G77 4G77 4G77 4G77
mature  peptidase 1.88 Å 4G8H 4G8H 4G8H 4G8H 4G8H 4G8H
mature  peptidase 1.68 Å 4GRK 4GRK 4GRK 4GRK 4GRK 4GRK
mature  peptidase 1.40 Å 4N6P 4N6P 4N6P 4N6P 4N6P 4N6P
mature  peptidase 2.10 Å 4NED 4NED 4NED 4NED 4NED 4NED
mature  peptidase 2.42 Å 4OQO 4OQO 4OQO 4OQO 4OQO 4OQO Rastogi et al., 2014
mature  peptidase 2.79 Å 5CRY 5CRY 5CRY 5CRY 5CRY 5CRY
intermediate structure of iron-saturated c-lobe of bovine lactoferrin at 2.79 angstrom resolution indicates the softening of iron coordination 2.79 Å 5HBC 5HBC 5HBC 5HBC 5HBC 5HBC
Bubalus bubalis
mature  peptidase 3.37 Å 1BIY 1BIY 1BIY 1BIY 1BIY 1BIY Karthikeyan et al., 2000
mature  peptidase 2.50 Å 1CE2 1CE2 1CE2 1CE2 1CE2 1CE2 Karthikeyan et al., 1999
Camelus dromedarius
mature  peptidase 2.65 Å 1DTZ 1DTZ 1DTZ 1DTZ 1DTZ 1DTZ Khan et al., 2001
mature  peptidase 2.70 Å 1I6Q 1I6Q 1I6Q 1I6Q 1I6Q 1I6Q Khan et al., 2001
Gallus gallus
apo form 3.00 Å 1AIV 1AIV 1AIV 1AIV 1AIV 1AIV Kurokawa et al., 1999
apo form 3.00 Å 1AIV 1AIV 1AIV 1AIV 1AIV 1AIV Kurokawa et al., 1999
mature  peptidase 3.20 Å 1D9K 1D9K 1D9K 1D9K 1D9K 1D9K Reinherz et al., 1999
N-terminal lobe, holo form 1.65 Å 1IEJ 1IEJ 1IEJ 1IEJ 1IEJ 1IEJ Mizutani et al., 2001
C-terminal lobe, apo form 2.30 Å 1IQ7 1IQ7 1IQ7 1IQ7 1IQ7 1IQ7 Mizutani et al., 2001
mature  peptidase 4.30 Å 1JL4 1JL4 1JL4 1JL4 1JL4 1JL4
mature  peptidase 2.80 Å 1N04 1N04 1N04 1N04 1N04 1N04 Guha et al., 2003
mature  peptidase 2.80 Å 1N04 1N04 1N04 1N04 1N04 1N04 Guha et al., 2003
N-terminal lobe, iron loaded open form 2.10 Å 1NFT 1NFT 1NFT 1NFT 1NFT 1NFT Mizutani et al., 1999
N-terminal lobe 2.30 Å 1NNT 1NNT 1NNT 1NNT 1NNT 1NNT Dewan et al., 1993
mature  peptidase 2.40 Å 1OVT 1OVT 1OVT 1OVT 1OVT 1OVT Kurokawa et al., 1995
mature  peptidase 2.40 Å 1OVT 1OVT 1OVT 1OVT 1OVT 1OVT Kurokawa et al., 1995
apo- form 3.50 Å 1RYX 1RYX 1RYX 1RYX 1RYX 1RYX Thakurta et al., 2004
apo- form 3.50 Å 1RYX 1RYX 1RYX 1RYX 1RYX 1RYX Thakurta et al., 2004
N-terminal lobe, apo form 1.90 Å 1TFA 1TFA 1TFA 1TFA 1TFA 1TFA Mizutani et al., 1999
aluminum-bound form 2.15 Å 2D3I 2D3I 2D3I 2D3I 2D3I 2D3I Mizutani et al., 2005
aluminum-bound form 2.15 Å 2D3I 2D3I 2D3I 2D3I 2D3I 2D3I Mizutani et al., 2005
Homo sapiens
diceric form 2.20 Å 1FCK 1FCK 1FCK 1FCK 1FCK 1FCK Baker et al., 2000
mature  peptidase 3.40 Å 1N76 1N76 1N76 1N76 1N76 1N76
crystals grown at pH 6.5 2.50 Å 1SQY 1SQY 1SQY 1SQY 1SQY 1SQY
recombinant form 2.40 Å 2BJJ 2BJJ 2BJJ 2BJJ 2BJJ 2BJJ Thomassen et al., 2005
fragment; complex with proteinase K and a human lactoferrin 2.90 Å 2DP4 2DP4 2DP4 2DP4 2DP4 2DP4
N-terminal lobe; complex with a lactoferrin-binding domain of pneumococcal surface protein A 2.91 Å 2PMS 2PMS 2PMS 2PMS 2PMS 2PMS Senkovich et al., 2007
Sus scrofa
mature  peptidase 2.15 Å 1H76 1H76 1H76 1H76 1H76 1H76 Hall et al., 2002

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