Structure for peptidase homologue S33.973: cytosolic epoxide hydrolase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Pharma

TERTIARY STRUCTURE DATA
Comment	Resolution	PDB	PDBe	SCOP	CATH	PDBSum	Proteopedia	Reference
Homo sapiens
mature peptidase	2.60 Å	1S8O	1S8O	1S8O	1S8O	1S8O	1S8O
complex with 4-(3-cyclohexyluriedo)-ethanoic acid	3.00 Å	1ZD2	1ZD2	1ZD2	1ZD2	1ZD2	1ZD2
complex with 4-(3-cyclohexyluriedo)-butyric acid	2.30 Å	1ZD3	1ZD3	1ZD3	1ZD3	1ZD3	1ZD3
complex with 4-(3-cyclohexyluriedo)-hexanoic acid	2.70 Å	1ZD4	1ZD4	1ZD4	1ZD4	1ZD4	1ZD4
complex with 4-(3-cyclohexyluriedo)-heptanoic acid	2.60 Å	1ZD5	1ZD5	1ZD5	1ZD5	1ZD5	1ZD5
complex with a synthetic inhibitor	1.98 Å	3ANS	3ANS	3ANS	3ANS	3ANS	3ANS
complex with a synthetic inhibitor	2.40 Å	3ANT	3ANT	3ANT	3ANT	3ANT	3ANT
crystal structure of soluble epoxide hydrolase	2.47 Å	3I1Y	3I1Y	3I1Y	3I1Y	3I1Y	3I1Y
crystal structure of soluble epoxide hydrolase	1.95 Å	3I28	3I28	3I28	3I28	3I28	3I28
mature peptidase	2.79 Å	3KOO	3KOO	3KOO	3KOO	3KOO	3KOO
soluble epoxide hydrolase in complex with pyrazole antagonist	3.00 Å	3OTQ	3OTQ	3OTQ	3OTQ	3OTQ	3OTQ
hydrolase domain; complex with a benzoxazole inhibitor	2.60 Å	3PDC	3PDC	3PDC	3PDC	3PDC	3PDC
complex with fragment inhibitor	2.11 Å	3WK4	3WK4	3WK4	3WK4	3WK4	3WK4
complex with fragment inhibitor	2.77 Å	3WK5	3WK5	3WK5	3WK5	3WK5	3WK5
complex with fragment inhibitor	2.10 Å	3WK6	3WK6	3WK6	3WK6	3WK6	3WK6
complex with fragment inhibitor	2.20 Å	3WK7	3WK7	3WK7	3WK7	3WK7	3WK7
complex with fragment inhibitor	2.20 Å	3WK8	3WK8	3WK8	3WK8	3WK8	3WK8
complex with fragment inhibitor	2.20 Å	3WK9	3WK9	3WK9	3WK9	3WK9	3WK9
complex with fragment inhibitor	2.01 Å	3WKA	3WKA	3WKA	3WKA	3WKA	3WKA
complex with fragment inhibitor	2.20 Å	3WKB	3WKB	3WKB	3WKB	3WKB	3WKB
complex with fragment inhibitor	2.20 Å	3WKC	3WKC	3WKC	3WKC	3WKC	3WKC
complex with fragment inhibitor	2.48 Å	3WKD	3WKD	3WKD	3WKD	3WKD	3WKD
complex with t-aucb	2.75 Å	3WKE	3WKE	3WKE	3WKE	3WKE	3WKE
complex with c9	2.17 Å	4C4X	4C4X	4C4X	4C4X	4C4X	4C4X
complex with a4	2.41 Å	4C4Y	4C4Y	4C4Y	4C4Y	4C4Y	4C4Y
complex with a8	2.06 Å	4C4Z	4C4Z	4C4Z	4C4Z	4C4Z	4C4Z
complex with n-cycloheptyl-1-(mesitylsulfonyl)piperidine-4-carboxamide.	2.55 Å	4HAI	4HAI	4HAI	4HAI	4HAI	4HAI
complex with fulvestrant	2.92 Å	4J03	4J03	4J03	4J03	4J03	4J03
complex with a carboxamide inhibitor	1.96 Å	4JNC	4JNC	4JNC	4JNC	4JNC	4JNC
complex with 1-(1-isobutyrylpiperidin-4-yl)-3-(4-(trifluoromethyl)phenyl)urea	2.94 Å	4OCZ	4OCZ	4OCZ	4OCZ	4OCZ	4OCZ
complex with 1-(1-propanoylpiperidin-4-yl)-3-[4-(trifluoromethoxy)phenyl]urea	2.92 Å	4OD0	4OD0	4OD0	4OD0	4OD0	4OD0
complex with a three substituted cyclopropane derivative	1.80 Å	4X6X	4X6X	4X6X	4X6X	4X6X	4X6X
complex with a cyclopropyl urea derivative	2.10 Å	4X6Y	4X6Y	4X6Y	4X6Y	4X6Y	4X6Y
complex with n-[(1-methyl- 1h-pyrazol-3-yl)methyl]-2-phenylethanamine	2.15 Å	4Y2J	4Y2J	4Y2J	4Y2J	4Y2J	4Y2J
complex with n-methyl-1-[3- (pyridin-3-yl)phenyl]methanamine	2.05 Å	4Y2P	4Y2P	4Y2P	4Y2P	4Y2P	4Y2P
complex with 1-[3- (trifluoromethyl)pyridin-2-yl]piperazine	2.40 Å	4Y2Q	4Y2Q	4Y2Q	4Y2Q	4Y2Q	4Y2Q
complex with 2-(piperazin-1-yl)nicotinonitrile	2.45 Å	4Y2R	4Y2R	4Y2R	4Y2R	4Y2R	4Y2R
complex with 1-[3- (trifluoromethyl)phenyl]-1h-pyrazol-4-ol	2.30 Å	4Y2S	4Y2S	4Y2S	4Y2S	4Y2S	4Y2S
complex with 3-[4- (benzyloxy)phenyl]propan-1-ol	2.40 Å	4Y2T	4Y2T	4Y2T	4Y2T	4Y2T	4Y2T
complex with tert-butyl 1,2,3,4-tetrahydroquinolin-3-ylcarbamate	2.75 Å	4Y2U	4Y2U	4Y2U	4Y2U	4Y2U	4Y2U
complex with (4-bromo-3- cyclopropyl-1h-pyrazol-1-yl)acetic acid	2.40 Å	4Y2V	4Y2V	4Y2V	4Y2V	4Y2V	4Y2V
complex with 2-([2- (adamantan-1-yl)ethyl]aminomethyl)phenol	2.50 Å	4Y2X	4Y2X	4Y2X	4Y2X	4Y2X	4Y2X
structure of soluble epoxide hydrolase in complex with 2-(2- fluorophenyl)-n-[(5-methyl-2-thienyl)methyl]ethanamine	2.30 Å	4Y2Y	4Y2Y	4Y2Y	4Y2Y	4Y2Y	4Y2Y
apo form	2.00 Å	5AHX	5AHX	5AHX	5AHX	5AHX	5AHX
ligand complex structure of soluble epoxide hydrolase	1.75 Å	5AI0	5AI0	5AI0	5AI0	5AI0	5AI0
ligand complex structure of soluble epoxide hydrolase	1.93 Å	5AI4	5AI4	5AI4	5AI4	5AI4	5AI4
ligand complex structure of soluble epoxide hydrolase	2.28 Å	5AI5	5AI5	5AI5	5AI5	5AI5	5AI5
ligand complex structure of soluble epoxide hydrolase	2.30 Å	5AI6	5AI6	5AI6	5AI6	5AI6	5AI6
ligand complex structure of soluble epoxide hydrolase	1.85 Å	5AI8	5AI8	5AI8	5AI8	5AI8	5AI8
ligand complex structure of soluble epoxide hydrolase	1.80 Å	5AI9	5AI9	5AI9	5AI9	5AI9	5AI9
ligand complex structure of soluble epoxide hydrolase	2.26 Å	5AIA	5AIA	5AIA	5AIA	5AIA	5AIA
ligand complex structure of soluble epoxide hydrolase	1.95 Å	5AIB	5AIB	5AIB	5AIB	5AIB	5AIB
ligand complex structure of soluble epoxide hydrolase	1.89 Å	5AIC	5AIC	5AIC	5AIC	5AIC	5AIC
ligand complex structure of soluble epoxide hydrolase	2.28 Å	5AK3	5AK3	5AK3	5AK3	5AK3	5AK3
ligand complex structure of soluble epoxide hydrolase	1.79 Å	5AK4	5AK4	5AK4	5AK4	5AK4	5AK4
ligand complex structure of soluble epoxide hydrolase	2.22 Å	5AK5	5AK5	5AK5	5AK5	5AK5	5AK5
ligand complex structure of soluble epoxide hydrolase	2.15 Å	5AK6	5AK6	5AK6	5AK6	5AK6	5AK6
ligand complex structure of soluble epoxide hydrolase	2.26 Å	5AKE	5AKE	5AKE	5AKE	5AKE	5AKE
ligand complex structure of soluble epoxide hydrolase	2.51 Å	5AKG	5AKG	5AKG	5AKG	5AKG	5AKG
ligand complex structure of soluble epoxide hydrolase	2.10 Å	5AKH	5AKH	5AKH	5AKH	5AKH	5AKH
ligand complex structure of soluble epoxide hydrolase	1.81 Å	5AKI	5AKI	5AKI	5AKI	5AKI	5AKI
ligand complex structure of soluble epoxide hydrolase	2.03 Å	5AKJ	5AKJ	5AKJ	5AKJ	5AKJ	5AKJ
ligand complex structure of soluble epoxide hydrolase	1.90 Å	5AKK	5AKK	5AKK	5AKK	5AKK	5AKK
ligand complex structure of soluble epoxide hydrolase	2.00 Å	5AKL	5AKL	5AKL	5AKL	5AKL	5AKL
ligand complex structure of soluble epoxide hydrolase	2.09 Å	5AKX	5AKX	5AKX	5AKX	5AKX	5AKX
ligand complex structure of soluble epoxide hydrolase	2.18 Å	5AKY	5AKY	5AKY	5AKY	5AKY	5AKY
ligand complex structure of soluble epoxide hydrolase	2.18 Å	5AKZ	5AKZ	5AKZ	5AKZ	5AKZ	5AKZ
ligand complex structure of soluble epoxide hydrolase	2.26 Å	5ALD	5ALD	5ALD	5ALD	5ALD	5ALD
ligand complex structure of soluble epoxide hydrolase	1.95 Å	5ALE	5ALE	5ALE	5ALE	5ALE	5ALE
ligand complex structure of soluble epoxide hydrolase	2.32 Å	5ALF	5ALF	5ALF	5ALF	5ALF	5ALF
ligand complex structure of soluble epoxide hydrolase	2.40 Å	5ALG	5ALG	5ALG	5ALG	5ALG	5ALG
ligand complex structure of soluble epoxide hydrolase	1.90 Å	5ALH	5ALH	5ALH	5ALH	5ALH	5ALH
ligand complex structure of soluble epoxide hydrolase	1.85 Å	5ALI	5ALI	5ALI	5ALI	5ALI	5ALI
ligand complex structure of soluble epoxide hydrolase	2.10 Å	5ALJ	5ALJ	5ALJ	5ALJ	5ALJ	5ALJ
ligand complex structure of soluble epoxide hydrolase	2.33 Å	5ALK	5ALK	5ALK	5ALK	5ALK	5ALK
ligand complex structure of soluble epoxide hydrolase	2.20 Å	5ALL	5ALL	5ALL	5ALL	5ALL	5ALL
ligand complex structure of soluble epoxide hydrolase	2.00 Å	5ALM	5ALM	5ALM	5ALM	5ALM	5ALM
ligand complex structure of soluble epoxide hydrolase	2.00 Å	5ALN	5ALN	5ALN	5ALN	5ALN	5ALN
ligand complex structure of soluble epoxide hydrolase	2.00 Å	5ALO	5ALO	5ALO	5ALO	5ALO	5ALO
ligand complex structure of soluble epoxide hydrolase	2.06 Å	5ALP	5ALP	5ALP	5ALP	5ALP	5ALP
ligand complex structure of soluble epoxide hydrolase	2.78 Å	5ALQ	5ALQ	5ALQ	5ALQ	5ALQ	5ALQ
ligand complex structure of soluble epoxide hydrolase	2.60 Å	5ALR	5ALR	5ALR	5ALR	5ALR	5ALR
ligand complex structure of soluble epoxide hydrolase	2.57 Å	5ALS	5ALS	5ALS	5ALS	5ALS	5ALS
ligand complex structure of soluble epoxide hydrolase	2.15 Å	5ALT	5ALT	5ALT	5ALT	5ALT	5ALT
ligand complex structure of soluble epoxide hydrolase	1.87 Å	5ALU	5ALU	5ALU	5ALU	5ALU	5ALU
ligand complex structure of soluble epoxide hydrolase	1.80 Å	5ALV	5ALV	5ALV	5ALV	5ALV	5ALV
ligand complex structure of soluble epoxide hydrolase	2.20 Å	5ALW	5ALW	5ALW	5ALW	5ALW	5ALW
ligand complex structure of soluble epoxide hydrolase	2.23 Å	5ALX	5ALX	5ALX	5ALX	5ALX	5ALX
ligand complex structure of soluble epoxide hydrolase	1.90 Å	5ALY	5ALY	5ALY	5ALY	5ALY	5ALY
ligand complex structure of soluble epoxide hydrolase	2.30 Å	5ALZ	5ALZ	5ALZ	5ALZ	5ALZ	5ALZ
ligand complex structure of soluble epoxide hydrolase	1.88 Å	5AM0	5AM0	5AM0	5AM0	5AM0	5AM0
ligand complex structure of soluble epoxide hydrolase	2.15 Å	5AM1	5AM1	5AM1	5AM1	5AM1	5AM1
ligand complex structure of soluble epoxide hydrolase	1.70 Å	5AM2	5AM2	5AM2	5AM2	5AM2	5AM2
ligand complex structure of soluble epoxide hydrolase	2.20 Å	5AM3	5AM3	5AM3	5AM3	5AM3	5AM3
ligand complex structure of soluble epoxide hydrolase	1.87 Å	5AM4	5AM4	5AM4	5AM4	5AM4	5AM4
ligand complex structure of soluble epoxide hydrolase	2.26 Å	5AM5	5AM5	5AM5	5AM5	5AM5	5AM5
ligand complex structure of soluble epoxide hydrolase	2.35 Å	5FP0	5FP0	5FP0	5FP0	5FP0	5FP0
complex with trans-4-[4-(3-trifluoromethoxyphenyl-l-ureido)-cyclohexyloxy]-benzoicacid.	2.95 Å	6AUM	6AUM	6AUM	6AUM	6AUM	6AUM
complex with lk864	2.26 Å	6FR2	6FR2	6FR2	6FR2	6FR2	6FR2
soluble epoxide hydrolase in complex with talinolol	2.00 Å	6HGV	6HGV	6HGV	6HGV	6HGV	6HGV
soluble epoxide hydrolase in complex with 1-(4-((4-(tert-butyl) morpholin-2-yl)methoxy)phenyl)-3-cyclohexylurea	2.16 Å	6HGX	6HGX	6HGX	6HGX	6HGX	6HGX
apo form C-terminal domain (hseh ctd)	2.60 Å	6I5E	6I5E	6I5E	6I5E	6I5E	6I5E
C-terminal domain (hseh ctd); complex with 15d-pgj2	2.00 Å	6I5G	6I5G	6I5G	6I5G	6I5G	6I5G
Mus musculus
mature peptidase	2.80 Å	1CQZ	1CQZ	1CQZ	1CQZ	1CQZ	1CQZ	Argiriadi et al., 1999
mature peptidase	2.80 Å	1CR6	1CR6	1CR6	1CR6	1CR6	1CR6	Argiriadi et al., 1999
mature peptidase	3.10 Å	1EK1	1EK1	1EK1	1EK1	1EK1	1EK1	Argiriadi et al., 2000
mature peptidase	3.00 Å	1EK2	1EK2	1EK2	1EK2	1EK2	1EK2	Argiriadi et al., 2000