Structure for peptidase S12.006: class C beta-lactamase

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Pharma

PDB	Organism	Resolution	Comment
1BLS	Enterobacter cloacae	2.30 Å	complex with (p-iodophenylacetylamino)methylphosphinic acid
The catalytic residues are shown in ball-and-stick representation: Ser84 in orange, Lys87 in purple and Tyr170 in green. The bound inhibitor is shown in grey ball-and-stick representation.

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TERTIARY STRUCTURE DATA
Comment	Resolution	PDB	PDBe	SCOP	CATH	PDBSum	Proteopedia	Reference
Acinetobacter baumannii
crystal structure of adc-1 beta-lactamase	1.20 Å	4NET	4NET	4NET	4NET	4NET	4NET
structure of adc-68, a novel carbapenem-hydrolyzing class c extended- spectrum -lactamase from acinetobacter baumannii	1.80 Å	4QD4	4QD4	4QD4	4QD4	4QD4	4QD4
crystal structure of adc-7 beta-lactamase	1.73 Å	4U0T	4U0T	4U0T	4U0T	4U0T	4U0T
complex with boronic acid inhibitor s02030	2.03 Å	4U0X	4U0X	4U0X	4U0X	4U0X	4U0X
complex with boronic acid transition state inhibitor ec04	1.88 Å	5W12	5W12	5W12	5W12	5W12	5W12
complex with boronic acid transition state inhibitor sm23	1.95 Å	5W13	5W13	5W13	5W13	5W13	5W13
complex with boronic acid transition state inhibitor s03043	1.88 Å	5W14	5W14	5W14	5W14	5W14	5W14
complex with boronic acid transition state inhibitor cr157	2.06 Å	5WAC	5WAC	5WAC	5WAC	5WAC	5WAC
complex with boronic acid transition state inhibitor cr161	2.09 Å	5WAD	5WAD	5WAD	5WAD	5WAD	5WAD
complex with boronic acid transition state inhibitor cr167	1.80 Å	5WAE	5WAE	5WAE	5WAE	5WAE	5WAE
complex with boronic acid transition state inhibitor cr192	2.03 Å	5WAF	5WAF	5WAF	5WAF	5WAF	5WAF
complex with boronic acid transition state inhibitor s06017	1.93 Å	5WAG	5WAG	5WAG	5WAG	5WAG	5WAG
Aeromonas enteropelogenes
crystal structure of the class c beta-lactamase tru-1 from aeromonas enteropelogenes	1.05 Å	6FM6	6FM6	6FM6	6FM6	6FM6	6FM6
complex with avibactam	1.04 Å	6FM7	6FM7	6FM7	6FM7	6FM7	6FM7
Burkholderia cenocepacia
crystal structure of d-alanine carboxypeptidase ampc from burkholderiacenocepacia	1.65 Å	5E2G	5E2G	5E2G	5E2G	5E2G	5E2G
Chromobacterium violaceum
crystal structure of beta-lactamase/d-alanine carboxypeptidase from chromobacterium violaceum	1.52 Å	5EVL	5EVL	5EVL	5EVL	5EVL	5EVL
Chromohalobacter sp. 560
wild type beta-lactamase derived from chromohalobacter sp.560	2.90 Å	3WRT	3WRT	3WRT	3WRT	3WRT	3WRT
n288q-n321q mutant beta-lactamase derived from chromohalobacter sp.560(without soaking)	1.80 Å	3WRZ	3WRZ	3WRZ	3WRZ	3WRZ	3WRZ
n288q-n321q mutant beta-lactamase derived from chromohalobacter sp.560(condition-1a)	2.00 Å	3WS0	3WS0	3WS0	3WS0	3WS0	3WS0
n288q-n321q mutant beta-lactamase derived from chromohalobacter sp.560(condition-1b)	1.80 Å	3WS1	3WS1	3WS1	3WS1	3WS1	3WS1
n288q-n321q mutant beta-lactamase derived from chromohalobacter sp.560(condition-1c)	2.10 Å	3WS2	3WS2	3WS2	3WS2	3WS2	3WS2
n288q-n321q mutant beta-lactamase derived from chromohalobacter sp.560(condition-2a)	1.90 Å	3WS4	3WS4	3WS4	3WS4	3WS4	3WS4
n288q-n321q mutant beta-lactamase derived from chromohalobacter sp.560(condition-2b)	2.80 Å	3WS5	3WS5	3WS5	3WS5	3WS5	3WS5
Citrobacter freundii
mature peptidase	2.00 Å	1FR1	1FR1	1FR1	1FR1	1FR1	1FR1
mature peptidase	2.50 Å	1FR6	1FR6	1FR6	1FR6	1FR6	1FR6
mature peptidase	1.52 Å	1RGY	1RGY	1RGY	1RGY	1RGY	1RGY	Nukaga et al., 2004
Enterobacter aerogenes
structural basis for the extended substrate spectrum of cmy- 10, a plasmid-encoded class c beta-lactamase	1.55 Å	1ZKJ	1ZKJ	1ZKJ	1ZKJ	1ZKJ	1ZKJ
crystal structure of a class c beta lactamase	1.55 Å	5F1F	5F1F	5F1F	5F1F	5F1F	5F1F
crystal structure of a class c beta lactamase of apo form	1.95 Å	5GSC	5GSC	5GSC	5GSC	5GSC	5GSC
complex with compound1	1.94 Å	5K1D	5K1D	5K1D	5K1D	5K1D	5K1D
complex with compound2	1.94 Å	5K1F	5K1F	5K1F	5K1F	5K1F	5K1F
Enterobacter cloacae
complex with (p-iodophenylacetylamino)methylphosphinic acid	2.30 Å	1BLS	1BLS	1BLS	1BLS	1BLS	1BLS	Lobkovsky et al., 1994
complex with a cephalosporin sulfone inhibitor	1.60 Å	1GA0	1GA0	1GA0	1GA0	1GA0	1GA0
mature peptidase	1.80 Å	1GCE	1GCE	1GCE	1GCE	1GCE	1GCE	Crichlow et al., 1999
gc1 beta-lactamase with a penem inhibitor	1.38 Å	1ONH	1ONH	1ONH	1ONH	1ONH	1ONH
complex with penem way185229	1.40 Å	1Q2Q	1Q2Q	1Q2Q	1Q2Q	1Q2Q	1Q2Q
mature peptidase	1.37 Å	1RGZ	1RGZ	1RGZ	1RGZ	1RGZ	1RGZ	Nukaga et al., 2004
complex with iodo-acetamido-phenyl boronic acid	2.24 Å	1S6R	1S6R	1S6R	1S6R	1S6R	1S6R
mature peptidase	1.88 Å	1XX2	1XX2	1XX2	1XX2	1XX2	1XX2
mature peptidase	2.10 Å	1Y54	1Y54	1Y54	1Y54	1Y54	1Y54	Michaux et al., 2005
homodimer	2.00 Å	2BLT	2BLT	2BLT	2BLT	2BLT	2BLT
mature peptidase	2.05 Å	2Q9M	2Q9M	2Q9M	2Q9M	2Q9M	2Q9M	Plantan et al., 2007
mature peptidase	2.20 Å	2Q9N	2Q9N	2Q9N	2Q9N	2Q9N	2Q9N	Plantan et al., 2007
mature peptidase	1.95 Å	3S4X	3S4X	3S4X	3S4X	3S4X	3S4X	Ruble et al., 2012
mature peptidase	1.75 Å	4XUX	4XUX	4XUX	4XUX	4XUX	4XUX	Hecker et al., 2015
Ser64Gly mutant	2.74 Å	5HAI	5HAI	5HAI	5HAI	5HAI	5HAI
complex with a penicillin derivative mpc-1	1.80 Å	5XHR	5XHR	5XHR	5XHR	5XHR	5XHR
Escherichia coli
mature peptidase	2.25 Å	1C3B	1C3B	1C3B	1C3B	1C3B	1C3B	Powers et al., 1999
mature peptidase	2.46 Å	1FCM	1FCM	1FCM	1FCM	1FCM	1FCM
mature peptidase	2.35 Å	1FCN	1FCN	1FCN	1FCN	1FCN	1FCN
mature peptidase	2.20 Å	1FCO	1FCO	1FCO	1FCO	1FCO	1FCO
mature peptidase	1.90 Å	1FSW	1FSW	1FSW	1FSW	1FSW	1FSW	Caselli et al., 2001
mature peptidase	1.75 Å	1FSY	1FSY	1FSY	1FSY	1FSY	1FSY	Caselli et al., 2001
mature peptidase	2.10 Å	1GA9	1GA9	1GA9	1GA9	1GA9	1GA9	Tondi et al., 2001
mature peptidase	1.83 Å	1I5Q	1I5Q	1I5Q	1I5Q	1I5Q	1I5Q	Trehan et al., 2001
mature peptidase	2.00 Å	1IEL	1IEL	1IEL	1IEL	1IEL	1IEL	Powers et al., 2001
mature peptidase	2.30 Å	1IEM	1IEM	1IEM	1IEM	1IEM	1IEM	Powers et al., 2001
mature peptidase	2.15 Å	1KDS	1KDS	1KDS	1KDS	1KDS	1KDS	Powers & Shoichet, 2002
mature peptidase	2.28 Å	1KDW	1KDW	1KDW	1KDW	1KDW	1KDW	Powers & Shoichet, 2002
mature peptidase	2.30 Å	1KE0	1KE0	1KE0	1KE0	1KE0	1KE0	Powers & Shoichet, 2002
mature peptidase	2.15 Å	1KE3	1KE3	1KE3	1KE3	1KE3	1KE3	Powers & Shoichet, 2002
mature peptidase	1.72 Å	1KE4	1KE4	1KE4	1KE4	1KE4	1KE4	Powers & Shoichet, 2002
mature peptidase	1.53 Å	1KVL	1KVL	1KVL	1KVL	1KVL	1KVL	Beadle et al., 2002
mature peptidase	2.06 Å	1KVM	1KVM	1KVM	1KVM	1KVM	1KVM	Beadle et al., 2002
mature peptidase	1.53 Å	1L0D	1L0D	1L0D	1L0D	1L0D	1L0D	Beadle & Shoichet, 2002
mature peptidase	1.90 Å	1L0E	1L0E	1L0E	1L0E	1L0E	1L0E	Beadle & Shoichet, 2002
mature peptidase	1.66 Å	1L0F	1L0F	1L0F	1L0F	1L0F	1L0F	Beadle & Shoichet, 2002
mature peptidase	1.50 Å	1L0G	1L0G	1L0G	1L0G	1L0G	1L0G	Beadle & Shoichet, 2002
mature peptidase	1.94 Å	1L2S	1L2S	1L2S	1L2S	1L2S	1L2S	Powers et al., 2002
mature peptidase	1.80 Å	1LL5	1LL5	1LL5	1LL5	1LL5	1LL5	Beadle & Shoichet, 2002
mature peptidase	1.87 Å	1LL9	1LL9	1LL9	1LL9	1LL9	1LL9	Trehan et al., 2002
mature peptidase	1.72 Å	1LLB	1LLB	1LLB	1LLB	1LLB	1LLB	Trehan et al., 2002
mature peptidase	1.83 Å	1MXO	1MXO	1MXO	1MXO	1MXO	1MXO	Morandi et al., 2003
mature peptidase	1.72 Å	1MY8	1MY8	1MY8	1MY8	1MY8	1MY8	Morandi et al., 2003
mature peptidase	1.71 Å	1O07	1O07	1O07	1O07	1O07	1O07	Meroueh et al., 2003
mature peptidase	1.39 Å	1PI4	1PI4	1PI4	1PI4	1PI4	1PI4	Roth et al., 2003
mature peptidase	1.49 Å	1PI5	1PI5	1PI5	1PI5	1PI5	1PI5	Roth et al., 2003
mature peptidase	1.96 Å	1XGI	1XGI	1XGI	1XGI	1XGI	1XGI	Tondi et al., 2005
mature peptidase	1.97 Å	1XGJ	1XGJ	1XGJ	1XGJ	1XGJ	1XGJ	Tondi et al., 2005
mature peptidase	2.00 Å	2BLS	2BLS	2BLS	2BLS	2BLS	2BLS	Usher et al., 1998
mature peptidase	1.07 Å	2FFY	2FFY	2FFY	2FFY	2FFY	2FFY	Chen et al., 2006
mature peptidase	2.10 Å	2HDQ	2HDQ	2HDQ	2HDQ	2HDQ	2HDQ	Babaoglu & Shoichet, 2006
mature peptidase	2.20 Å	2HDR	2HDR	2HDR	2HDR	2HDR	2HDR	Babaoglu & Shoichet, 2006
mature peptidase	1.16 Å	2HDS	2HDS	2HDS	2HDS	2HDS	2HDS	Babaoglu & Shoichet, 2006
mature peptidase	1.49 Å	2HDU	2HDU	2HDU	2HDU	2HDU	2HDU	Babaoglu & Shoichet, 2006
mature peptidase	2.20 Å	2I72	2I72	2I72	2I72	2I72	2I72	Venturelli et al., 2007
mature peptidase	1.80 Å	2P9V	2P9V	2P9V	2P9V	2P9V	2P9V	Wyrembak et al., 2007
mature peptidase	1.86 Å	2PU2	2PU2	2PU2	2PU2	2PU2	2PU2	Babaoglu et al., 2008
mature peptidase	2.00 Å	2PU4	2PU4	2PU4	2PU4	2PU4	2PU4	Babaoglu et al., 2008
mature peptidase	1.80 Å	2R9W	2R9W	2R9W	2R9W	2R9W	2R9W	Babaoglu et al., 2008
mature peptidase	1.90 Å	2R9X	2R9X	2R9X	2R9X	2R9X	2R9X	Babaoglu et al., 2008
mature peptidase	2.00 Å	2RCX	2RCX	2RCX	2RCX	2RCX	2RCX	Morandi et al., 2008
tripeptide deletion (Gly286 Ser287 Asp288) on the h10 helix	1.70 Å	2ZJ9	2ZJ9	2ZJ9	2ZJ9	2ZJ9	2ZJ9
mature peptidase	2.30 Å	3BLS	3BLS	3BLS	3BLS	3BLS	3BLS	Usher et al., 1998
mature peptidase	2.10 Å	3BM6	3BM6	3BM6	3BM6	3BM6	3BM6	Tondi et al., 2010
mature peptidase	1.85 Å	3FKV	3FKV	3FKV	3FKV	3FKV	3FKV	Chen et al., 2009
mature peptidase	1.50 Å	3FKW	3FKW	3FKW	3FKW	3FKW	3FKW	Chen et al., 2009
mature peptidase	1.80 Å	3GQZ	3GQZ	3GQZ	3GQZ	3GQZ	3GQZ	Teotico et al., 2009
mature peptidase	1.80 Å	3GR2	3GR2	3GR2	3GR2	3GR2	3GR2	Teotico et al., 2009
mature peptidase	2.49 Å	3GRJ	3GRJ	3GRJ	3GRJ	3GRJ	3GRJ	Teotico et al., 2009
mature peptidase	2.10 Å	3GSG	3GSG	3GSG	3GSG	3GSG	3GSG	Teotico et al., 2009
mature peptidase	1.90 Å	3GTC	3GTC	3GTC	3GTC	3GTC	3GTC	Teotico et al., 2009
mature peptidase	1.80 Å	3GV9	3GV9	3GV9	3GV9	3GV9	3GV9	Teotico et al., 2009
mature peptidase	1.80 Å	3GVB	3GVB	3GVB	3GVB	3GVB	3GVB	Teotico et al., 2009
mature peptidase	1.64 Å	3IWI	3IWI	3IWI	3IWI	3IWI	3IWI	Thomas et al., 2010
mature peptidase	1.90 Å	3IWO	3IWO	3IWO	3IWO	3IWO	3IWO	Thomas et al., 2010
mature peptidase	1.84 Å	3IWQ	3IWQ	3IWQ	3IWQ	3IWQ	3IWQ	Thomas et al., 2010
mature peptidase	1.63 Å	3IXB	3IXB	3IXB	3IXB	3IXB	3IXB	Thomas et al., 2010
mature peptidase	2.64 Å	3IXD	3IXD	3IXD	3IXD	3IXD	3IXD	Thomas et al., 2010
mature peptidase	2.14 Å	3IXG	3IXG	3IXG	3IXG	3IXG	3IXG	Thomas et al., 2010
mature peptidase	2.30 Å	3IXH	3IXH	3IXH	3IXH	3IXH	3IXH	Thomas et al., 2010
mature peptidase	1.60 Å	3O86	3O86	3O86	3O86	3O86	3O86	Eidam et al., 2010
mature peptidase	1.78 Å	3O87	3O87	3O87	3O87	3O87	3O87	Eidam et al., 2010
mature peptidase	1.64 Å	3O88	3O88	3O88	3O88	3O88	3O88	Eidam et al., 2010
mature peptidase	1.60 Å	4E3I	4E3I	4E3I	4E3I	4E3I	4E3I	Eidam et al., 2012
mature peptidase	1.80 Å	4E3J	4E3J	4E3J	4E3J	4E3J	4E3J	Eidam et al., 2012
mature peptidase	1.43 Å	4E3K	4E3K	4E3K	4E3K	4E3K	4E3K	Eidam et al., 2012
mature peptidase	1.43 Å	4E3L	4E3L	4E3L	4E3L	4E3L	4E3L	Eidam et al., 2012
mature peptidase	1.44 Å	4E3M	4E3M	4E3M	4E3M	4E3M	4E3M	Eidam et al., 2012
mature peptidase	1.49 Å	4E3N	4E3N	4E3N	4E3N	4E3N	4E3N	Eidam et al., 2012
mature peptidase	1.60 Å	4E3O	4E3O	4E3O	4E3O	4E3O	4E3O	Eidam et al., 2012
mature peptidase	1.65 Å	4JXG	4JXG	4JXG	4JXG	4JXG	4JXG
mature peptidase	1.90 Å	4JXS	4JXS	4JXS	4JXS	4JXS	4JXS	Hendershot et al., 2014
mature peptidase	1.76 Å	4JXV	4JXV	4JXV	4JXV	4JXV	4JXV	Hendershot et al., 2014
mature peptidase	2.30 Å	4JXW	4JXW	4JXW	4JXW	4JXW	4JXW	Hendershot et al., 2014
mature peptidase	1.89 Å	4KEN	4KEN	4KEN	4KEN	4KEN	4KEN
mature peptidase	1.89 Å	4KG2	4KG2	4KG2	4KG2	4KG2	4KG2
mature peptidase	2.11 Å	4KG5	4KG5	4KG5	4KG5	4KG5	4KG5
mature peptidase	1.75 Å	4KG6	4KG6	4KG6	4KG6	4KG6	4KG6
mature peptidase	1.67 Å	4KZ3	4KZ3	4KZ3	4KZ3	4KZ3	4KZ3	Barelier et al., 2014
mature peptidase	1.42 Å	4KZ4	4KZ4	4KZ4	4KZ4	4KZ4	4KZ4	Barelier et al., 2014
mature peptidase	1.35 Å	4KZ5	4KZ5	4KZ5	4KZ5	4KZ5	4KZ5	Barelier et al., 2014
mature peptidase	1.68 Å	4KZ6	4KZ6	4KZ6	4KZ6	4KZ6	4KZ6	Barelier et al., 2014
mature peptidase	1.43 Å	4KZ7	4KZ7	4KZ7	4KZ7	4KZ7	4KZ7	Barelier et al., 2014
mature peptidase	2.28 Å	4KZ8	4KZ8	4KZ8	4KZ8	4KZ8	4KZ8	Barelier et al., 2014
mature peptidase	1.72 Å	4KZ9	4KZ9	4KZ9	4KZ9	4KZ9	4KZ9	Barelier et al., 2014
mature peptidase	1.60 Å	4KZA	4KZA	4KZA	4KZA	4KZA	4KZA	Barelier et al., 2014
mature peptidase	1.37 Å	4KZB	4KZB	4KZB	4KZB	4KZB	4KZB	Barelier et al., 2014
mature peptidase	1.65 Å	4LV0	4LV0	4LV0	4LV0	4LV0	4LV0	London et al., 2014
mature peptidase	1.74 Å	4LV1	4LV1	4LV1	4LV1	4LV1	4LV1	London et al., 2014
mature peptidase	1.65 Å	4LV2	4LV2	4LV2	4LV2	4LV2	4LV2	London et al., 2014
mature peptidase	1.42 Å	4LV3	4LV3	4LV3	4LV3	4LV3	4LV3	London et al., 2014
mature peptidase	1.37 Å	4OKP	4OKP	4OKP	4OKP	4OKP	4OKP	Barelier et al., 2014
mature peptidase	1.48 Å	4OLD	4OLD	4OLD	4OLD	4OLD	4OLD	Barelier et al., 2014
mature peptidase	1.71 Å	4OLG	4OLG	4OLG	4OLG	4OLG	4OLG	Barelier et al., 2014
crystal structure of fox-4 cephamycinase	1.63 Å	5CGS	5CGS	5CGS	5CGS	5CGS	5CGS
crystal structure of fox-4 cephamycinase mutant y150f	1.40 Å	5CGW	5CGW	5CGW	5CGW	5CGW	5CGW
Tyr150Phe mutant; complex with cefoxitin	1.21 Å	5CGX	5CGX	5CGX	5CGX	5CGX	5CGX
complex with cephalothin batsi (sm23)	1.36 Å	5CHJ	5CHJ	5CHJ	5CHJ	5CHJ	5CHJ
complex with ceftazidime batsi (lp06)	1.90 Å	5CHM	5CHM	5CHM	5CHM	5CHM	5CHM
complex with sulfate	1.10 Å	5CHU	5CHU	5CHU	5CHU	5CHU	5CHU
crystal structure of a class c beta lactamase	1.76 Å	5F1G	5F1G	5F1G	5F1G	5F1G	5F1G
crystal structure of class c beta-lactamase	1.76 Å	5GGW	5GGW	5GGW	5GGW	5GGW	5GGW
crystal structure of ampc ber	1.49 Å	5GZW	5GZW	5GZW	5GZW	5GZW	5GZW
crystal structure of the s61a mutant of ampc ber	1.75 Å	5JOC	5JOC	5JOC	5JOC	5JOC	5JOC
complex with avibactam	1.50 Å	5ZA2	5ZA2	5ZA2	5ZA2	5ZA2	5ZA2
complex with nanomolar inhibitor	1.79 Å	6DPT	6DPT	6DPT	6DPT	6DPT	6DPT
complex with inhibitor	1.90 Å	6DPX	6DPX	6DPX	6DPX	6DPX	6DPX
complex with inhibitor	1.91 Å	6DPY	6DPY	6DPY	6DPY	6DPY	6DPY
complex with inhibitor	1.50 Å	6DPZ	6DPZ	6DPZ	6DPZ	6DPZ	6DPZ
crystal structure of cmy-136 class c beta-lactamase	1.60 Å	6G9T	6G9T	6G9T	6G9T	6G9T	6G9T
beta-lactamase from escherichia coli str. sakai	1.60 Å	6N9K	6N9K	6N9K	6N9K	6N9K	6N9K
Klebsiella pneumoniae
complex with a citrate molecule	2.09 Å	1ZC2	1ZC2	1ZC2	1ZC2	1ZC2	1ZC2
crystal structure of class c beta-lactamase act-1	2.40 Å	2ZC7	2ZC7	2ZC7	2ZC7	2ZC7	2ZC7
crystal structure of class c beta-lactamase mox-1	1.50 Å	3W8K	3W8K	3W8K	3W8K	3W8K	3W8K
complex with aztorenam	1.90 Å	4WBG	4WBG	4WBG	4WBG	4WBG	4WBG
complex with a boronic acid transition state inhibitor s02030	2.13 Å	5ZYB	5ZYB	5ZYB	5ZYB	5ZYB	5ZYB
Mycobacterium smegmatis
crystal structure of d-alanine carboxypeptidase ampc from mycobacterium smegmatis	1.80 Å	5E2H	5E2H	5E2H	5E2H	5E2H	5E2H
Pseudomonas syringae
crystal structure of beta-lactamase/d-alanine carboxypeptidase from pseudomonas syringae	1.80 Å	5EVI	5EVI	5EVI	5EVI	5EVI	5EVI