Structure for peptidase S01.214: coagulation factor IXa

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

PDB	Organism	Resolution	Comment
1PFX	Sus scrofa	3.00 Å	complex with D-Phe-Pro-Arg
Catalytic residues are shown in ball-and-stick representation: His85 in purple, Asp133 in pink and Ser229 in orange. The N-terminal light chain is shown in yellow. D-Phe-Pro-Arg peptide is shown in grey in ball-and-stick representation.

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TERTIARY STRUCTURE DATA
Comment	Resolution	PDB	PDBe	SCOP	CATH	PDBSum	Proteopedia	Reference
Bos taurus
mature peptidase	1.55 Å	1J34	1J34	1J34	1J34	1J34	1J34	Shikamoto et al., 2003
mature peptidase	1.80 Å	1J35	1J35	1J35	1J35	1J35	1J35	Shikamoto et al., 2003
Homo sapiens
NMR; residues 1-47	0.00 Å	1CFH	1CFH	1CFH	1CFH	1CFH	1CFH	Freedman et al., 1995
NMR structure; gamma-carboxy-glutamic acid-rich domain	0.00 Å	1CFI	1CFI	1CFI	1CFI	1CFI	1CFI	Freedman et al., 1995
EGF-like domain	1.50 Å	1EDM	1EDM	1EDM	1EDM	1EDM	1EDM	Rao et al., 1995
NMR; EGF-like module	0.00 Å	1IXA	1IXA	1IXA	1IXA	1IXA	1IXA	Baron et al., 1992
NMR; alpha-carbon backbone only	0.00 Å	1MGX	1MGX	1MGX	1MGX	1MGX	1MGX	Freedman et al., 1996
mature peptidase	2.20 Å	1NL0	1NL0	1NL0	1NL0	1NL0	1NL0	Huang et al., 2004
complex with p-amino-benzamidine	2.80 Å	1RFN	1RFN	1RFN	1RFN	1RFN	1RFN	Hopfner et al., 1999
mature peptidase	1.50 Å	2WPH	2WPH	2WPH	2WPH	2WPH	2WPH	Zogg & Brandstetter, 2009
mature peptidase	1.99 Å	2WPI	2WPI	2WPI	2WPI	2WPI	2WPI	Zogg & Brandstetter, 2009
mature peptidase	1.60 Å	2WPJ	2WPJ	2WPJ	2WPJ	2WPJ	2WPJ	Zogg & Brandstetter, 2009
mature peptidase	2.21 Å	2WPK	2WPK	2WPK	2WPK	2WPK	2WPK	Zogg & Brandstetter, 2009
mature peptidase	1.82 Å	2WPL	2WPL	2WPL	2WPL	2WPL	2WPL	Zogg & Brandstetter, 2009
mature peptidase	2.00 Å	2WPM	2WPM	2WPM	2WPM	2WPM	2WPM	Zogg & Brandstetter, 2009
mature peptidase	1.70 Å	3KCG	3KCG	3KCG	3KCG	3KCG	3KCG	Johnson et al., 2010
mature peptidase	1.90 Å	3LC3	3LC3	3LC3	3LC3	3LC3	3LC3	Wang et al., 2010
mature peptidase	2.62 Å	3LC5	3LC5	3LC5	3LC5	3LC5	3LC5	Wang et al., 2010
mature peptidase	2.37 Å	4WM0	4WM0	4WM0	4WM0	4WM0	4WM0
mature peptidase	1.62 Å	4WMA	4WMA	4WMA	4WMA	4WMA	4WMA
mature peptidase	2.05 Å	4WMB	4WMB	4WMB	4WMB	4WMB	4WMB
mature peptidase	1.87 Å	4WMI	4WMI	4WMI	4WMI	4WMI	4WMI
mature peptidase	2.08 Å	4WMK	4WMK	4WMK	4WMK	4WMK	4WMK
mature peptidase	1.95 Å	4WN2	4WN2	4WN2	4WN2	4WN2	4WN2
mature peptidase	1.95 Å	4WNH	4WNH	4WNH	4WNH	4WNH	4WNH
mature peptidase	1.41 Å	4YZU	4YZU	4YZU	4YZU	4YZU	4YZU	Parker et al., 2015
mature peptidase	1.41 Å	4Z0K	4Z0K	4Z0K	4Z0K	4Z0K	4Z0K	Parker et al., 2015
mature peptidase	1.86 Å	4ZAE	4ZAE	4ZAE	4ZAE	4ZAE	4ZAE	Zhang et al., 2015
mature peptidase	1.84 Å	5EGM	5EGM	5EGM	5EGM	5EGM	5EGM	Meng et al., 2015
Lys98Thr variant; complex with egr- chloromethylketone	1.45 Å	5JB8	5JB8	5JB8	5JB8	5JB8	5JB8
Lys98Thr variant; complex with PPACK	1.30 Å	5JB9	5JB9	5JB9	5JB9	5JB9	5JB9
Val16Ile/Lys98Thr/Tyr177Thr/Ile212Val variant; complex with PPACK	1.40 Å	5JBA	5JBA	5JBA	5JBA	5JBA	5JBA
Val16Ile/Lys98Thr/Tyr177Thr/Ile213val variant; complex with egr-chloromethylketone	1.56 Å	5JBB	5JBB	5JBB	5JBB	5JBB	5JBB
Val16Ile/Lys98Thr/Tyr177Thr/Ile213val variant; complex with PPACK	1.90 Å	5JBC	5JBC	5JBC	5JBC	5JBC	5JBC
discovery of novel aminobenzisoxazole derivatives as orally available factor ixa inhibitors	1.54 Å	5TNO	5TNO	5TNO	5TNO	5TNO	5TNO
discovery of novel aminobenzisoxazole derivatives as orally available factor ixa inhibitors	1.40 Å	5TNT	5TNT	5TNT	5TNT	5TNT	5TNT
mature peptidase	1.37 Å	6MV4	6MV4	6MV4	6MV4	6MV4	6MV4
crystal structure of egrck-inhibited gla-domainless fixa (k148q, r150qvariant)	1.60 Å	6RFK	6RFK	6RFK	6RFK	6RFK	6RFK
Sus scrofa
complex with D-Phe-Pro-Arg	3.00 Å	1PFX	1PFX	1PFX	1PFX	1PFX	1PFX	Brandstetter et al., 1995
porcine factor ixa complexed to 1-3-[amino(imino) methyl]phenyl-n-[4-(1h-benzimidazol-1-yl)-2-fluorophenyl]- 3-(trifluoromethyl)-1h-pyrazole-5-carboxamide	2.90 Å	1X7A	1X7A	1X7A	1X7A	1X7A	1X7A	Smallheer et al., 2004