Structure for peptidase M14.009: carboxypeptidase B2

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

 

PDB Organism Resolution Comment
3D66_A Homo sapiens 3.10 Å mature
The zinc ligands are shown in ball-and-stick representation: His181 and His310 in purple and Glu184 in blue. The catalytic residues are shown in ball-and-stick representation: Arg239 in dark blue and Glu385 in light blue. The propeptide is shown in grey.
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TERTIARY STRUCTURE DATA
Comment Resolution PDB PDBe SCOP CATH PDBSum Proteopedia Reference
Bos taurus
complex with tick carboxypeptidase inhibitor 1.70 Å 3D4U 3D4U 3D4U 3D4U 3D4U 3D4U Barbosa et al., 2002
CRYSTAL STRUCTURE OF THROMBIN ACTIVATABLE FIBRINOLYSIS INHIBITOR TITLE 2 (TAFI) 2.50 Å 3DGV 3DGV 3DGV 3DGV 3DGV 3DGV
mature  peptidase 6.00 Å 3OSL 3OSL 3OSL 3OSL 3OSL 3OSL Valnickova et al., 2010
Homo sapiens
mature  peptidase 3.10 Å 3D66 3D66 3D66 3D66 3D66 3D66 Marx et al., 2008
crystal structure of thrombin-activatable fibrinolysis inhibitor (tafi); complex with 2-guanidino-ethyl- mercaptosuccinic acid (gemsa) 3.40 Å 3D67 3D67 3D67 3D67 3D67 3D67 Marx et al., 2008
crystal structure of a t325i/t329i/h333y/h335q mutant of thrombin-activatable fibrinolysis inhibitor (tafi-iiyq) 2.80 Å 3D68 3D68 3D68 3D68 3D68 3D68 Marx et al., 2008
mature  peptidase 2.50 Å 3LMS 3LMS 3LMS 3LMS 3LMS 3LMS Sanglas et al., 2010
mature  peptidase 2.00 Å 4P10 4P10 4P10 4P10 4P10 4P10 Brink et al., 2014
crystal structure of thrombin-activatable fibrinolysis inhibitor in complex with an inhibitory nanobody (vhh-i83) 2.85 Å 5HVF 5HVF 5HVF 5HVF 5HVF 5HVF
crystal structure of thrombin-activatable fibrinolysis inhibitor in complex with an inhibitory nanobody (vhh-a204) 3.05 Å 5HVG 5HVG 5HVG 5HVG 5HVG 5HVG
crystal structure of thrombin-activatable fibrinolysis inhibitor in complex with two inhibitory nanobodies 3.00 Å 5HVH 5HVH 5HVH 5HVH 5HVH 5HVH