Structure for inhibitor I04.018: antithrombin

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Pharma

PDB	Organism	Resolution	Comment
1E04	Homo sapiens	2.60 Å	mature
The reactive site Arg393 is shown in blue ball-and-stick representation.

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TERTIARY STRUCTURE DATA
Comment	Resolution	PDB	PDBe	SCOP	CATH	PDBSum	Proteopedia	Reference
Bos taurus
cleaved form	3.20 Å	1ATT	1ATT	1ATT	1ATT	1ATT	1ATT	Mourey et al., 1993
Homo sapiens
dimer	3.00 Å	1ANT	1ANT	1ANT	1ANT	1ANT	1ANT	Carrell et al., 1994
mature inhibitor	3.20 Å	1ATH	1ATH	1ATH	1ATH	1ATH	1ATH	Schreuder et al., 1994
complex with pentasaccharide	2.90 Å	1AZX	1AZX	1AZX	1AZX	1AZX	1AZX	Jin et al., 1997
binary complex	2.90 Å	1BR8	1BR8	1BR8	1BR8	1BR8	1BR8	Skinner et al., 1998
mature inhibitor	2.80 Å	1DZG	1DZG	1DZG	1DZG	1DZG	1DZG	Huntington et al., 2000
p14-fluorescein-n135q-s380c-antithrombin-iii	2.85 Å	1DZH	1DZH	1DZH	1DZH	1DZH	1DZH	Huntington et al., 2000
complex with pentasaccharide	2.90 Å	1E03	1E03	1E03	1E03	1E03	1E03	Jin et al., 1997
mature inhibitor	2.60 Å	1E04	1E04	1E04	1E04	1E04	1E04	Skinner et al., 1997
mature inhibitor	2.61 Å	1E05	1E05	1E05	1E05	1E05	1E05	Skinner et al., 1997
complex with a P14-P8 reactive loop peptide, and an exogenous tetrapeptide	2.60 Å	1JVQ	1JVQ	1JVQ	1JVQ	1JVQ	1JVQ	Zhou et al., 2004
dimeric form; complex with a P14-P9 reactive loop peptide and an exogenous tripeptide	2.80 Å	1LK6	1LK6	1LK6	1LK6	1LK6	1LK6	Zhou et al., 2003
pentasaccharide-bound intermediate state	2.60 Å	1NQ9	1NQ9	1NQ9	1NQ9	1NQ9	1NQ9	Johnson & Huntington, 2003
P13 alanine variant	2.62 Å	1OYH	1OYH	1OYH	1OYH	1OYH	1OYH	Johnson & Huntington, 2004
structure of dimeric antithrombin complexed with a p14-p9 reactive loop peptide and an exogenous tripeptide (formyl- norleucine-lf)	2.70 Å	1R1L	1R1L	1R1L	1R1L	1R1L	1R1L
antithrombin-anhydrothrombin-heparin ternary complex structure	3.10 Å	1SR5	1SR5	1SR5	1SR5	1SR5	1SR5	Dementiev et al., 2004
monomeric form	2.75 Å	1T1F	1T1F	1T1F	1T1F	1T1F	1T1F	Johnson et al., 2006
complex with thrombin and heparin	2.50 Å	1TB6	1TB6	1TB6	1TB6	1TB6	1TB6	Li et al., 2004
Dimer of latent and active molecules	2.60 Å	2ANT	2ANT	2ANT	2ANT	2ANT	2ANT	Skinner et al., 1997
mature inhibitor	2.80 Å	2B4X	2B4X	2B4X	2B4X	2B4X	2B4X
complex between antithrombin, synthetic heparin mimetic sr123781 and two s195a thrombin molecules	2.10 Å	2B5T	2B5T	2B5T	2B5T	2B5T	2B5T	Johnson et al., 2006
Ser137Ala/Val317Cys/Thr401Cys variant	2.70 Å	2BEH	2BEH	2BEH	2BEH	2BEH	2BEH	Johnson et al., 2006
Ser195Ala variant; complex with factor Xa and pentasaccharide	3.30 Å	2GD4	2GD4	2GD4	2GD4	2GD4	2GD4	Johnson et al., 2006
P14 alanine variant	2.90 Å	2HIJ	2HIJ	2HIJ	2HIJ	2HIJ	2HIJ
domain-swapped dimer	2.80 Å	2ZNH	2ZNH	2ZNH	2ZNH	2ZNH	2ZNH	Yamasaki et al., 2008
intermediate structure of antithrombin bound to the natural pentasaccharide	3.00 Å	3EVJ	3EVJ	3EVJ	3EVJ	3EVJ	3EVJ
hyperstable in-frame insertion variant of antithrombin	2.80 Å	4EB1	4EB1	4EB1	4EB1	4EB1	4EB1