PDBe 4eb1

X-ray diffraction
2.8Å resolution

Hyperstable in-frame insertion variant of antithrombin

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Antithrombin-III Chain: I
Molecule details ›
Chain: I
Length: 440 amino acids
Theoretical weight: 49.93 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P01008 (Residues: 33-240, 243-464; Coverage: 100%)
Gene names: AT3, PRO0309, SERPINC1
Structure domains:
Antithrombin-III Chain: L
Molecule details ›
Chain: L
Length: 432 amino acids
Theoretical weight: 49.1 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P01008 (Residues: 33-464; Coverage: 100%)
Gene names: AT3, PRO0309, SERPINC1
Sequence domains: Serpin (serine protease inhibitor)
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P21
Unit cell:
a: 69.75Å b: 101.75Å c: 88.81Å
α: 90° β: 105.42° γ: 90°
R-values:
R R work R free
0.201 0.198 0.255
Expression system: Homo sapiens