PDBe 1lk6

X-ray diffraction
2.8Å resolution

Structure of dimeric antithrombin complexed with a P14-P9 reactive loop peptide and an exogenous tripeptide

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Antithrombin-III Chains: I, L
Molecule details ›
Chains: I, L
Length: 432 amino acids
Theoretical weight: 49.1 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P01008 (Residues: 33-464; Coverage: 100%)
Gene names: AT3, PRO0309, SERPINC1
Sequence domains: Serpin (serine protease inhibitor)
Structure domains:
antithrombin P14-P9 peptide Chain: C
Molecule details ›
Chain: C
Length: 7 amino acids
Theoretical weight: 561 Da
Source organism: Synthetic construct
Expression system: Not provided
exogenous tripeptide formyl-MLF Chain: D
Molecule details ›
Chain: D
Length: 3 amino acids
Theoretical weight: 438 Da
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

3 bound ligands:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX14.2
Spacegroup: P21
Unit cell:
a: 68.811Å b: 99.908Å c: 87.292Å
α: 90° β: 104.44° γ: 90°
R-values:
R R work R free
0.202 0.202 0.266
Expression system: Not provided