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Literature for inhibitor I04.018: antithrombin

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Pharma

(Topics flags: S Structure, M Mutation, P Specificity, K Knockout, E Expression, U Therapeutic, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Balogh,G. and Bereczky,Z.
    The Effects of Heparin Binding and Arg596 Mutations on the Conformation of Thrombin-Antithrombin Michaelis Complex, Revealed by Enhanced Sampling Molecular Dynamics Simulations
    Int J Mol Sci (2025) 26 PubMed  Europe PubMed DOI  PMC  EPMC
  2. Hsu,E. and Moosavi,L.
    Biochemistry, Antithrombin III
     (2025) PubMed  Europe PubMed
  3. Hsu,E. and Moosavi,L.
    Biochemistry, Antithrombin III
     (2025) PubMed  Europe PubMed
    4. 2024
  4. Garrido-Rodriguez,P., Carmena-Bargueno,M., Morena-Barrio,M.E., Bravo-Perez,C., Morena-Barrio,B., Cifuentes-Riquelme,R., Lozano,M.L., Perez-Sanchez,H. and Corral,J.
    Analysis of AlphaFold and molecular dynamics structure predictions of mutations in serpins
    PLoS ONE (2024) 19, e0304451-e0304451. PubMed  Europe PubMed DOI  PMC  EPMC
  5. Saboor,M., Hamali,H.A., Mobarki,A.A., Madkhali,A.M. and Dboie,G.
    Exploring antithrombin: insights into its physiological features, clinical implications and analytical techniques
    Blood Coagul Fibrinolysis (2024) 35, 43-48. PubMed  Europe PubMed DOI  V
    6. 2023
  6. Carvalho,T.
    siRNA against anti-thrombin reduces bleeding in hemophilia
    Nat Med (2023) 29, 1288-1289. PubMed  Europe PubMed DOI
    7. 2022
  7. Bhagwat,S.R., Choudhary,K., Pandya,N., Sharma,S., Srivastava,S., Kumar,A. and Hajela,K.
    Identification of substrates of MBL Associated Serine Protease-1 (MASP-1) from human plasma using N-terminomics strategy
    Mol Immunol (2022) 151, 114-125. PubMed  Europe PubMed DOI
    8. 2021
  8. Gindele,R., Penzes-Daku,K., Balogh,G., Kallai,J., Bogati,R., Becsi,B., Erdodi,F., Katona,E. and Bereczky,Z.
    Investigation of the Differences in Antithrombin to Heparin Binding among Antithrombin Budapest 3, Basel, and Padua Mutations by Biochemical and In Silico Methods
    Biomolecules (2021) 11 PubMed  Europe PubMed DOI  PMC  EPMC
  9. Izaguirre,G., Swanson,R., Roth,R., Gettins,P.G.W. and Olson,S.T.
    Paramount Importance of Core Conformational Changes for Heparin Allosteric Activation of Antithrombin
    Biochemistry (2021) 60, 1201-1213. PubMed  Europe PubMed DOI
  10. Xu,D., Wu,J., Chen,J., Jiang,L., Chen,J., Bao,W., Chen,X., Yang,Q., Zhang,X., Yao,L., Su,H. and Liu,J.
    Cullin 2-RBX1 E3 ligase and USP2 regulate antithrombin ubiquitination and stability
    FASEB J (2021) 35, e21800-e21800. PubMed  Europe PubMed DOI  K
    11. 2020
  11. Aymonnier,K., Kawecki,C., Arocas,V., Boulaftali,Y. and Bouton,M.C.
    Serpins, New Therapeutic Targets for Hemophilia
    Thromb Haemost (2020) PubMed  Europe PubMed DOI  V
  12. Boban,A. and Hermans,C.
    Safety of relaxing coagulation control by anti-TFPI in hemophilia patients: impact of tissue distribution of tissue factor
    J Thromb Haemost (2020) PubMed  Europe PubMed DOI
  13. de Laat-Kremers,R.M.W., Yan,Q., Ninivaggi,M., de Maat,M. and de Laat,B.
    Deciphering the coagulation profile through the dynamics of thrombin activity
    Sci Rep (2020) 10, 12544-12544. PubMed  Europe PubMed DOI  PMC  EPMC
  14. Krenzlin,H., Frenz,C., Schmitt,J., Masomi-Bornwasser,J., Wesp,D., Kalasauskas,D., Kerz,T., Lotz,J., Alessandri,B., Ringel,F. and Keric,N.
    High CSF thrombin concentration and activity is associated with an unfavorable outcome in patients with intracerebral hemorrhage
    PLoS ONE (2020) 15, e0241565-e0241565. PubMed  Europe PubMed DOI  PMC  EPMC
  15. Lu,Y., Villoutreix,B.O., Biswas,I., Ding,Q., Wang,X. and Rezaie,A.R.
    Thr90Ser Mutation in antithrombin is associated with recurrent thrombosis in a heterozygous carrier
    Thromb Haemost (2020) PubMed  Europe PubMed DOI  M
  16. Rezaie,A.R. and Giri,H.
    Anticoagulant and signaling functions of antithrombin
    J Thromb Haemost (2020) PubMed  Europe PubMed DOI  V
  17. Siritapetawee,J., Khunkaewla,P. and Thumanu,K.
    Roles of a protease from Euphorbia resinifera latex in human anticoagulant and antithrombotic activities
    Chem Biol Interact (2020) 329, 109223-109223. PubMed  Europe PubMed DOI
    18. 2019
  18. Adams,B.M., Ke,H., Gierasch,L.M., Gershenson,A. and Hebert,D.N.
    Proper secretion of the serpin antithrombin relies strictly on thiol-dependent quality control
    J Biol Chem (2019) 294, 18992-19011. PubMed  Europe PubMed DOI
  19. Rehman,S.U., Ashraf,S., Ahamad,S., Sarwar,T., Husain,M.A., Ahmad,P., Tabish,M. and Jairajpuri,M.A.
    Identification of a novel alternatively spliced isoform of antithrombin containing an additional RCL-like loop
    Biochem Biophys Res Commun (2019) 517, 421-426. PubMed  Europe PubMed DOI
    20. 2018
  20. Amiral,J. and Seghatchian,J.
    Revisiting antithrombin in health and disease, congenital deficiencies and genetic variants, and laboratory studies on alpha and beta forms
    Transfus Apher Sci (2018) 57, 291-297. PubMed  Europe PubMed DOI  V
  21. Arantes,P.R., Perez-Sanchez,H. and Verli,H.
    Antithrombin conformational modulation by D-myo-inositol 3,4,5,6-tetrakisphosphate (TMI), a novel scaffold for the development of antithrombotic agents
    J Biomol Struct Dyn (2018) 36, 4045-4056. PubMed  Europe PubMed DOI
  22. Deshpande,R., Pathare,A., Alkindi,S., Al Zadjali,S., Ghosh,K. and Shetty,S.
    A novel p.Pro353His SERPINC1 mutation in the thrombin-binding region affecting stability of antithrombin molecule in an extended Omani family
    Int J Lab Hematol (2018) 40, e49-e49. PubMed  Europe PubMed DOI  M
    23. 2017
  23. Aguila,S., Izaguirre,G., Martinez-Martinez,I., Vicente,V., Olson,S.T. and Corral,J.
    Disease-causing mutations in the serpin antithrombin reveal a key domain critical for inhibiting protease activities
    J Biol Chem (2017) 292, 16513-16520. PubMed  Europe PubMed DOI  M
  24. Verhamme,I.M.
    A novel antithrombin domain dictates the journey's end of a proteinase
    J Biol Chem (2017) 292, 16521-16522. PubMed  Europe PubMed DOI  PMC  EPMC  M
    25. 2016
  25. Chandrasekhar,K., Ke,H., Wang,N., Goodwin,T., Gierasch,L.M., Gershenson,A. and Hebert,D.N.
    Cellular folding pathway of a metastable serpin
    Proc Natl Acad Sci U S A (2016) 113, 6484-6489. PubMed  Europe PubMed DOI
  26. Luengo-Gil,G., Calvo,M.I., Martin-Villar,E., Aguila,S., Bohdan,N., Anton,A.I., Espin,S., Ayala de la Pena,F., Vicente,V., Corral,J., Quintanilla,M. and Martinez-Martinez,I.
    Antithrombin controls tumor migration, invasion and angiogenesis by inhibition of enteropeptidase
    Sci Rep (2016) 6, 27544-27544. PubMed  Europe PubMed DOI  PMC  EPMC
  27. Su,J., Shu,L., Zhang,Z., Cai,L., Zhang,X., Zhai,Y. and Liu,J.
    A small deletion in SERPINC1 causes type I antithrombin deficiency by promoting endoplasmic reticulum stress
    Oncotarget (2016) 7, 76882-76890. PubMed  Europe PubMed DOI  M
    28. 2015
  28. Roth,R., Swanson,R., Izaguirre,G., Bock,S.C., Gettins,P.G. and Olson,S.T.
    Saturation mutagenesis of the antithrombin reactive center loop P14 residue supports a three-step mechanism of heparin allosteric activation involving intermediate and fully activated states
    J Biol Chem (2015) 290, 28020-28036. PubMed  Europe PubMed DOI
  29. Toth,L., Fekete,A., Balogh,G., Bereczky,Z. and Komaromi,I.
    Dynamic properties of the native free antithrombin from molecular dynamics simulations: computational evidence for solvent-exposed Arg393 side chain
    J Biomol Struct Dyn (2015) 33, 2023-2036. PubMed  Europe PubMed DOI
    30. 2014
  30. Izaguirre,G., Aguila,S., Qi,L., Swanson,R., Roth,R., Rezaie,A.R., Gettins,P.G. and Olson,S.T.
    Conformational activation of antithrombin by heparin involves an altered exosite interaction with protease
    J Biol Chem (2014) 289, 34049-34064. PubMed  Europe PubMed DOI
  31. Yang,L., Dinarvand,P., Qureshi,S.H. and Rezaie,A.R.
    Engineering D-helix of antithrombin in alpha-1-proteinase inhibitor confers antiinflammatory properties on the chimeric serpin
    Thromb Haemost (2014) 112, 164-175. PubMed  Europe PubMed DOI  E
    32. 2013
  32. Hepner,M. and Karlaftis,V.
    Antithrombin
    Methods Mol Biol (2013) 992, 355-364. PubMed  Europe PubMed DOI  V
  33. Huntington,J.A.
    Thrombin inhibition by the serpins
    J Thromb Haemost (2013) 11 Suppl 1, 254-264. PubMed  Europe PubMed DOI
  34. Talbot,K., Meixner,S.C. and Pryzdial,E.L.
    Proteolytic modulation of factor Xa-antithrombin complex enhances fibrinolysis in plasma
    Biochim Biophys Acta (2013) 1834, 989-995. PubMed  Europe PubMed DOI
    35. 2012
  35. Asmal,M., Whitney,J.B., Luedemann,C., Carville,A., Steen,R., Letvin,N.L. and Geiben-Lynn,R.
    In vivo anti-HIV activity of the heparin-activated serine protease inhibitor antithrombin III encapsulated in lymph-targeting immunoliposomes
    PLoS ONE (2012) 7, e48234-e48234. PubMed  Europe PubMed DOI  PMC  EPMC  U
  36. Martinez-Martinez,I., Johnson,D.J., Yamasaki,M., Navarro-Fernandez,J., Ordonez,A., Vicente,V., Huntington,J.A. and Corral,J.
    Type II antithrombin deficiency caused by a large in-frame insertion: structural, functional and pathological relevance
    J Thromb Haemost (2012) 10, 1859-1866. PubMed  Europe PubMed DOI  M
  37. Nakatomi,Y., Tsuji,M., Gokudan,S., Hanada-Dateki,T., Nakashima,T., Miyazaki,H., Hamamoto,T., Nakagaki,T. and Tomokiyo,K.
    Stable complex formation between serine protease inhibitor and zymogen: coagulation factor X cleaves the Arg393-Ser394 bond in a reactive centre loop of antithrombin in the presence of heparin
    J Biochem (2012) 152, 463-470. PubMed  Europe PubMed DOI  P
  38. Olivieri,M., Bidlingmaier,C., Schetzeck,S., Borggrafe,I., Geisen,C. and Kurnik,K.
    Arterial thrombosis in homozygous antithrombin deficiency
    Hamostaseologie (2012) 32 Suppl 1, S79-S82. PubMed  Europe PubMed  M
    39. 2011
  39. Chou,F.P., Xu,H., Lee,M.S., Chen,Y.W., Durand Richards,O.X., Swanson,R., Olson,S.T., Johnson,M.D. and Lin,C.Y.
    Matriptase is inhibited by extravascular antithrombin in epithelial cells but not in most carcinoma cells
    Am J Physiol Cell Physiol (2011) 301, C1093-C1103. PubMed  Europe PubMed DOI
  40. Gierczak,R.F., Sutherland,J.S., Bhakta,V., Toltl,L.J., Liaw,P.C. and Sheffield,W.P.
    Retention of thrombin inhibitory activity by recombinant serpins expressed as integral membrane proteins tethered to the surface of mammalian cells
    J Thromb Haemost (2011) 9, 2424-2435. PubMed  Europe PubMed DOI
  41. Huntington,J.A.
    Serpin structure, function and dysfunction
    J Thromb Haemost (2011) 9 Suppl 1, 26-34. PubMed  Europe PubMed DOI  S
    42. 2010
  42. Johnson,D.J., Langdown,J. and Huntington,J.A.
    Molecular basis of factor IXa recognition by heparin-activated antithrombin revealed by a 1.7-A structure of the ternary complex
    Proc Natl Acad Sci U S A (2010) 107, 645-650. PubMed  Europe PubMed DOI  PMC  EPMC  S
  43. Martinez-Martinez,I., Ordonez,A., Navarro-Fernandez,J., Perez-Lara,A., Gutierrez-Gallego,R., Giraldo,R., Martinez,C., Llop,E., Vicente,V. and Corral,J.
    Antithrombin Murcia (K241E) causing antithrombin deficiency: a possible role for altered glycosylation
    Haematologica (2010) 95, 1358-1365. PubMed  Europe PubMed DOI  M
  44. Yang,L., Manithody,C., Qureshi,S.H. and Rezaie,A.R.
    Inhibitory properties of the P1 Tyr variant of antithrombin
    Biochemistry (2010) 49, 2680-2686. PubMed  Europe PubMed DOI
  45. Yang,L., Manithody,C., Qureshi,S.H. and Rezaie,A.R.
    Role of the residues of the 39-loop in determining the substrate and inhibitor specificity of factor IXa
    J Biol Chem (2010) 285, 28488-28495. PubMed  Europe PubMed DOI
    46. 2009
  46. Langdown,J., Belzar,K.J., Savory,W.J., Baglin,T.P. and Huntington,J.A.
    The critical role of hinge-region expulsion in the induced-fit heparin binding mechanism of antithrombin
    J Mol Biol (2009) 386, 1278-1289. PubMed  Europe PubMed DOI  PMC  EPMC
  47. Mickowska,B.
    Purification and characterization of alpha(1)-proteinase inhibitor and antithrombin III: major serpins of rainbow trout (Oncorhynchuss mykiss) and carp (Cyprinus carpio) blood plasma
    Fish Physiol Biochem (2009) 35, 231-240. PubMed  Europe PubMed DOI
  48. Yang,L., Qureshi,S.H., Manithody,C. and Rezaie,A.R.
    Role of P2 glycine in determining the specificity of antithrombin reaction with coagulation proteases
    Biochem Biophys Res Commun (2009) 389, 162-167. PubMed  Europe PubMed DOI  PMC  EPMC
    49. 2007
  49. Gonzales,P.R., Walston,T.D., Camacho,L.O., Kielar,D.M., Church,F.C., Rezaie,A.R. and Cooper,S.T.
    Mutation of the H-helix in antithrombin decreases heparin stimulation of protease inhibition
    Biochim Biophys Acta (2007) 1774, 1431-1437. PubMed  Europe PubMed DOI  PMC  EPMC
  50. Izaguirre,G., Swanson,R., Raja,S.M., Rezaie,A.R. and Olson,S.T.
    Mechanism by which exosites promote the inhibition of blood coagulation proteases by heparin-activated antithrombin
    J Biol Chem (2007) 282, 33609-33622. PubMed  Europe PubMed DOI
  51. Kjellberg,M., Rimac,B. and Stenflo,J.
    An immunochemical method for quantitative determination of latent antithrombin, the reactive center loop-inserted uncleaved form of antithrombin
    J Thromb Haemost (2007) 5, 127-132. PubMed  Europe PubMed DOI
    52. 2006
  52. [YEAR:3-5-2006]Johnson,D.J., Li,W., Adams,T.E. and Huntington,J.A.
    Antithrombin-S195A factor Xa-heparin structure reveals the allosteric mechanism of antithrombin activation
    EMBO J (3-5-2006) 25, 2029-2037. PubMed  Europe PubMed DOI  PMC  EPMC  S
  53. [YEAR:13-9-2006]Johnson,D.J., Langdown,J., Li,W., Luis,S.A., Baglin,T.P. and Huntington,J.A.
    Crystal structure of monomeric native antithrombin reveals a novel reactive center loop conformation
    J Biol Chem (13-9-2006) 281, 35478-35486. PubMed  Europe PubMed DOI  PMC  EPMC  S
  54. [YEAR:25-4-2006]Rezaie,A.R.
    Pentasaccharide enhances the inactivation of factor Xa by antithrombin by promoting the assembly of a Michaelis-type intermediate complex. Demonstration by rapid kinetic, surface plasmon resonance, and competitive binding studies
    Biochemistry (25-4-2006) 45, 5324-5329. PubMed  Europe PubMed DOI  PMC  EPMC
    55. 2005
  55. [YEAR:24-2-2005]Monien,B.H. and Desai,U.R.
    Antithrombin activation by nonsulfated, non-polysaccharide organic polymer
    J Med Chem (24-2-2005) 48, 1269-1273. PubMed  Europe PubMed DOI
  56. Picard,V., Bauters,A., Khairy,M., Ochat,N., Jude,B., Aiach,M. and Alhenc-Gelas,M.
    Conformational Asn187Asp/Lys antithrombin variants and thrombosis. Clinical and biological features in 13 new heterozygotes
    Thromb Haemost (2005) 93, 57-62. PubMed  Europe PubMed DOI
  57. Wang,W.B., Fu,Q.H., Ding,Q.L., Zhou,R.F., Wu,W.M., Hu,Y.Q., Wang,X.F., Yan,L.X., Wang,Z.Y. and Wang,H.L.
    Characterization of molecular defect of 13387-9delG mutated antithrombin in inherited type I antithrombin deficiency
    Blood Coagul Fibrinolysis (2005) 16, 149-155. PubMed  Europe PubMed  M
    58. 2004
  58. Dementiev,A., Petitou,M., Herbert,J.M. and Gettins,P.G.
    The ternary complex of antithrombin-anhydrothrombin-heparin reveals the basis of inhibitor specificity
    Nat Struct Mol Biol (2004) 11, 863-867. PubMed  Europe PubMed DOI  S
  59. [YEAR:6-2-2004]Johnson,D.J. and Huntington,J.A.
    The influence of hinge region residue Glu-381 on antithrombin allostery and metastability
    J Biol Chem (6-2-2004) 279, 4913-4921. PubMed  Europe PubMed DOI
  60. Messmore,H.L., Wehrmacher,W.H., Coyne,E. and Fareed,J.
    Heparin to pentasaccharide and beyond: the end is not in sight
    Semin Thromb Hemost (2004) 30 Suppl 1, 81-88. PubMed  Europe PubMed DOI
  61. Quinsey,N.S., Greedy,A.L., Bottomley,S.P., Whisstock,J.C. and Pike,R.N.
    Antithrombin: in control of coagulation
    Int J Biochem Cell Biol (2004) 36, 386-389. PubMed  Europe PubMed DOI
  62. [YEAR:16-3-2004]Rezaie,A.R., Yang,L. and Manithody,C.
    Mutagenesis studies toward understanding the mechanism of differential reactivity of factor Xa with the native and heparin-activated antithrombin
    Biochemistry (16-3-2004) 43, 2898-2905. PubMed  Europe PubMed DOI
  63. [YEAR:27-1-2004]Schedin-Weiss,S., Desai,U.R., Bock,S.C., Olson,S.T. and Bjork,I.
    Roles of N-terminal region residues Lys11, Arg13, and Arg24 of antithrombin in heparin recognition and in promotion and stabilization of the heparin-induced conformational change
    Biochemistry (27-1-2004) 43, 675-683. PubMed  Europe PubMed DOI
  64. Taoka,Y., Okajima,K. and Uchiba,M.
    Antithrombin reduces compression-induced spinal cord injury in rats
    J Neurotrauma (2004) 21, 1818-1830. PubMed  Europe PubMed DOI
  65. [YEAR:3-6-2004]Yang,L., Manithody,C. and Rezaie,A.R.
    Heparin-activated antithrombin interacts with the autolysis loop of target coagulation proteases
    Blood (3-6-2004) 104, 1753-1759. PubMed  Europe PubMed DOI
    66. 2003
  66. [YEAR:26-9-2003]Dementiev,A., Simonovic,M., Volz,K. and Gettins,P.G.
    Canonical inhibitor-like interactions explain reactivity of alpha1-proteinase inhibitor Pittsburgh and antithrombin with proteinases
    J Biol Chem (26-9-2003) 278, 37881-37887. PubMed  Europe PubMed DOI  M  S
  67. [YEAR:28-11-2003]Dewerchin,M., Herault,J.P., Wallays,G., Petitou,M., Schaeffer,P., Millet,L., Weitz,J.I., Moons,L., Collen,D., Carmeliet,P. and Herbert,J.M.
    Life-threatening thrombosis in mice with targeted Arg48-to-Cys mutation of the heparin-binding domain of antithrombin
    Circ Res (28-11-2003) 93, 1120-1126. PubMed  Europe PubMed DOI
  68. Johnson,D.J. and Huntington,J.A.
    Crystal structure of antithrombin in a heparin-bound intermediate state
    Biochemistry (2003) 42, 8712-8719. PubMed  Europe PubMed DOI  S
  69. Kremser,L., Bruckner,A., Heger,A., Grunert,T., Buchacher,A., Josic,D., Allmaier,G. and Rizzi,A.
    Characterization of antithrombin III from human plasma by two-dimensional gel electrophoresis and capillary electrophoretic methods
    Electrophoresis (2003) 24, 4282-4290. PubMed  Europe PubMed DOI
  70. [YEAR:1-12-2003]Mushunje,A., Zhou,A., Carrell,R.W. and Huntington,J.A.
    Heparin-induced substrate behavior of antithrombin Cambridge II
    Blood (1-12-2003) 102, 4028-4034. PubMed  Europe PubMed DOI
  71. Zhou,A., Stein,P.E., Huntington,J.A. and Carrell,R.W.
    Serpin polymerization is prevented by a hydrogen bond network that is centered on His-334 and stabilized by glycerol
    J Biol Chem (2003) 278, 15116-15122. PubMed  Europe PubMed DOI  S
    72. 2002
  72. [YEAR:5-7-2002]Jairajpuri,M.A., Lu,A. and Bock,S.C.
    Elimination of P1 arginine 393 interaction with underlying glutamic acid 255 partially activates antithrombin III for thrombin inhibition but not factor Xa inhibition
    J Biol Chem (5-7-2002) 277, 24460-24465. PubMed  Europe PubMed DOI
  73. [YEAR:3-5-2002]Quinsey,N.S., Whisstock,J.C., Le Bonniec,B., Louvain,V., Bottomley,S.P. and Pike,R.N.
    Molecular determinants of the mechanism underlying acceleration of the interaction between antithrombin and factor Xa by heparin pentasaccharide
    J Biol Chem (3-5-2002) 277, 15971-15978. PubMed  Europe PubMed DOI
  74. [YEAR:8-10-2002]Rezaie,A.R.
    Insight into the molecular basis of coagulation proteinase specificity by mutagenesis of the serpin antithrombin
    Biochemistry (8-10-2002) 41, 12179-12185. PubMed  Europe PubMed DOI
  75. Roemisch,J., Gray,E., Hoffmann,J.N. and Wiedermann,C.J.
    Antithrombin: a new look at the actions of a serine protease inhibitor
    Blood Coagul Fibrinolysis (2002) 13, 657-670. PubMed  Europe PubMed DOI
  76. [YEAR:16-4-2002]Schedin-Weiss,S., Desai,U.R., Bock,S.C., Gettins,P.G., Olson,S.T. and Bjork,I.
    Importance of lysine 125 for heparin binding and activation of antithrombin
    Biochemistry (16-4-2002) 41, 4779-4788. PubMed  Europe PubMed DOI
    77. 2001
  77. [YEAR:5-6-2001]Futamura,A., Beechem,J.M. and Gettins,P.G.W.
    Conformational equilibrium of the reactive center loop of antithrombin examined by steady state and time-resolved fluorescence measurements: Consequences for the mechanism of factor Xa inhibition by antithrombin-heparin complexes
    Biochemistry (5-6-2001) 40, 6680-6687. PubMed  Europe PubMed DOI
    78. 2000
  78. Hopkins,P.C.R., Pike,R.N. and Stone,S.R.
    Evolution of serpin specificity: cooperative interactions in the reactive-site loop sequence of antithrombin specifically restrict the inhibition of activated protein C
    J Mol Evol (2000) 51, 507-515. PubMed  Europe PubMed
  79. Huntington,J.A., McCoy,A., Belzar,K.J., Pei,X.Y., Gettins,P.G. and Carrell,R.W.
    The conformational activation of antithrombin. A 2.85-A structure of a fluorescein derivative reveals an electrostatic link between the hinge and heparin binding regions
    J Biol Chem (2000) 275, 15377-15383. PubMed  Europe PubMed DOI  S
  80. Ishiguro,K., Kojima,T., Kadomatsu,K., Nakayama,Y., Takagi,A., Suzuki,M., Takeda,N., Ito,M., Yamamoto,K., Matsushita,T., Kusugami,K., Muramatsu,T. and Saito,H.
    Complete antithrombin deficiency in mice results in embryonic lethality
    J Clin Invest (2000) 106, 873-878. PubMed  Europe PubMed DOI  PMC  EPMC  K
    81. 1998
  81. [YEAR:1-11-1998]Bjork,I., Nordling,K., Raub-Segall,E., Hellman,U. and Olson,S.T.
    Inactivation of papain by antithrombin due to autolytic digestion: a model of serpin inactivation of cysteine proteinases
    Biochem J (1-11-1998) 335, 701-709. PubMed  Europe PubMed  PMC  EPMC
  82. [YEAR:10-3-1998]Huntington,J.A. and Gettins,P.G.
    Conformational conversion of antithrombin to a fully activated substrate of factor Xa without need for heparin
    Biochemistry (10-3-1998) 37, 3272-3277. PubMed  Europe PubMed DOI
  83. Skinner,R., Chang,W.S., Jin,L., Pei,X., Huntington,J.A., Abrahams,J.P., Carrell,R.W. and Lomas,D.A.
    Implications for function and therapy of a 2.9 A structure of binary-complexed antithrombin
    J Mol Biol (1998) 283, 9-14. PubMed  Europe PubMed DOI  S
    84. 1997
  84. Jin,L., Abrahams,J.P., Skinner,R., Petitou,M., Pike,R.N. and Carrell,R.W.
    The anticoagulant activation of antithrombin by heparin
    Proc Natl Acad Sci U S A (1997) 94, 14683-14688. PubMed  Europe PubMed DOI  PMC  EPMC  S
  85. Skinner,R., Abrahams,J.P., Whisstock,J.C., Lesk,A.M., Carrell,R.W. and Wardell,M.R.
    The 2.6 A structure of antithrombin indicates a conformational change at the heparin binding site
    J Mol Biol (1997) 266, 601-609. PubMed  Europe PubMed DOI  S
    86. 1994
  86. Perry,D.J.
    Antithrombin and its inherited deficiencies
    Blood Rev (1994) 8, 37-55. PubMed  Europe PubMed DOI  V
    87. 1993
  87. [YEAR:1-9-1993]Broze,G.J., Jr., Likert,K. and Higuchi,D.
    Inhibition of factor VIIa/tissue factor by antithrombin III and tissue factor pathway inhibitor
    Blood (1-9-1993) 82, 1679-1681. PubMed  Europe PubMed
  88. [YEAR:15-2-1993]Sheehan,J.P., Wu,Q., Tollefsen,D.M. and Sadler,J.E.
    Mutagenesis of thrombin selectively modulates inhibition by serpins heparin cofactor II and antithrombin III. Interaction with the anion-binding exosite determines heparin cofactor II specificity
    J Biol Chem (15-2-1993) 268, 3639-3645. PubMed  Europe PubMed
  89. Wardell,M.R., Abrahams,J.P., Bruce,D., Skinner,R. and Leslie,A.G.
    Crystallization and preliminary X-ray diffraction analysis of two conformations of intact human antithrombin
    J Mol Biol (1993) 234, 1253-1258. PubMed  Europe PubMed DOI  S
    90. 1991
  90. Mast,A.E., Enghild,J.J., Nagase,H., Suzuki,K., Pizzo,S.V. and Salvesen,G.
    Kinetics and physiologic relevance of the inactivation of alpha1- proteinase inhibitor, alpha1-antichymotrypsin, and antithrombin III by matrix metalloproteinases-1 (tissue collagenase), -2 (72-kDa gelatinase/type IV collagenase), and -3 (stromelysin)
    J Biol Chem (1991) 266, 15810-15816. PubMed  Europe PubMed
  91. Mejdoub,H., Le Ret,M., Boulanger,Y., Maman,M., Choay,J. and Reinbolt,J.
    The complete amino acid sequence of bovine antithrombin (ATIII)
    J Protein Chem (1991) 10, 205-212. PubMed  Europe PubMed
    92. 1989
  92. [YEAR:25-6-1989]Jordan,R.E., Nelson,R.M., Kilpatrick,J., Newgren,J.O., Esmon,P.C. and Fournel,M.A.
    Inactivation of human antithrombin by neutrophil elastase. Kinetics of the heparin-dependent reaction
    J Biol Chem (25-6-1989) 264, 10493-10500. PubMed  Europe PubMed
    93. 1986
  93. Bjork,I. and Danielsson,A.
    Antithrombin and related inhibitors of coagulation proteinases
    [ISSN:0-444-80763-2] (1986) , 489-514.  V
    94. 1985
  94. [YEAR:24-10-1985]Carrell,R.W. and Owen,M.C.
    Plakalbumin, alpha 1-antitrypsin, antithrombin and the mechanism of inflammatory thrombosis
    Nature (24-10-1985) 317, 730-732. PubMed  Europe PubMed
  95. [YEAR:12-3-1985]Fish,W.W., Danielsson,A., Nordling,K., Miller,S.H., Lam,C.F. and Bjork,I.
    Denaturation behavior of antithrombin in guanidinium chloride. Irreversibility of unfolding caused by aggregation
    Biochemistry (12-3-1985) 24, 1510-1517. PubMed  Europe PubMed
  96. [YEAR:25-2-1985]Griffith,M.J., Noyes,C.M. and Church,F.C.
    Reactive site peptide structural similarity between heparin cofactor II and antithrombin III
    J Biol Chem (25-2-1985) 260, 2218-2225. PubMed  Europe PubMed
  97. [YEAR:10-1-1985]Peterson,C.B. and Blackburn,M.N.
    Isolation and characterization of an antithrombin III variant with reduced carbohydrate content and enhanced heparin binding
    J Biol Chem (10-1-1985) 260, 610-615. PubMed  Europe PubMed
    98. 1984
  98. Atha,D.H., Stephens,A.W. and Rosenberg,R.D.
    Evaluation of critical groups required for the binding of heparin to antithrombin
    Proc Natl Acad Sci U S A (1984) 81, 1030-1034. PubMed  Europe PubMed  PMC  EPMC
  99. [YEAR:25-1-1984]Blackburn,M.N., Smith,R.L., Carson,J. and Sibley,C.C.
    The heparin-binding site of antithrombin III. Identification of a critical tryptophan in the amino acid sequence
    J Biol Chem (25-1-1984) 259, 939-941. PubMed  Europe PubMed
  100. Fuchs,H.E., Michalopoulos,G.K. and Pizzo,S.V.
    Hepatocyte uptake of alpha 1-proteinase inhibitor-trypsin complexes in vitro: evidence for a shared uptake mechanism for proteinase complexes of alpha 1-proteinase inhibitor and antithrombin III
    J Cell Biochem (1984) 25, 231-243. PubMed  Europe PubMed DOI
  101. Fuchs,H.E., Shifman,M.A., Michalopoulos,G. and Pizzo,S.V.
    Hepatocyte receptors for antithrombin III-proteinase complexes
    J Cell Biochem (1984) 24, 197-206. PubMed  Europe PubMed DOI
  102. [YEAR:10-6-1984]Gitel,S.N., Medina,V.M. and Wessler,S.
    Inhibition of human activated factor X by antithrombin III and alpha 1-proteinase inhibitor in human plasma
    J Biol Chem (10-6-1984) 259, 6890-6895. PubMed  Europe PubMed
  103. [YEAR:10-5-1984]Hoylaerts,M., Owen,W.G. and Collen,D.
    Involvement of heparin chain length in the heparin-catalyzed inhibition of thrombin by antithrombin III
    J Biol Chem (10-5-1984) 259, 5670-5677. PubMed  Europe PubMed
  104. [YEAR:15-5-1984]Jesty,J., Morrison,S.A. and Harpel,P.C.
    Measurement of human activated factor X-antithrombin complex by an enzyme-linked differential-antibody immunosorbent assay
    Anal Biochem (15-5-1984) 139, 158-167. PubMed  Europe PubMed
  105. Kao,F.T., Morse,H.G., Law,M.L., Lidsky,A., Chandra,T. and Woo,S.L.
    Genetic mapping of the structural gene for antithrombin III to human chromosome 1
    Hum Genet (1984) 67, 34-36. PubMed  Europe PubMed
  106. Karp,G.I., Marcum,J.A. and Rosenberg,R.D.
    The role of tryptophan residues in heparin-antithrombin interactions
    Arch Biochem Biophys (1984) 233, 712-720. PubMed  Europe PubMed
  107. Koide,T., Odani,S., Takahashi,K., Ono,T. and Sakuragawa,N.
    Antithrombin III Toyama: replacement of arginine-47 by cysteine in hereditary abnormal antithrombin III that lacks heparin-binding ability
    Proc Natl Acad Sci U S A (1984) 81, 289-293. PubMed  Europe PubMed  PMC  EPMC  M
  108. [YEAR:25-10-1984]Lindahl,U., Thunberg,L., Backstrom,G., Riesenfeld,J., Nordling,K. and Bjork,I.
    Extension and structural variability of the antithrombin-binding sequence in heparin
    J Biol Chem (25-10-1984) 259, 12368-12376. PubMed  Europe PubMed
  109. [YEAR:25-1-1984]Pecon,J.M. and Blackburn,M.N.
    Pyridoxylation of essential lysines in the heparin-binding site of antithrombin III
    J Biol Chem (25-1-1984) 259, 935-938. PubMed  Europe PubMed
  110. [YEAR:15-2-1984]Rosenfeld,L. and Danishefsky,I.
    Effects of enzymatic deglycosylation on the biological activities of human thrombin and antithrombin
    Arch Biochem Biophys (15-2-1984) 229, 359-367. PubMed  Europe PubMed
  111. Suzuki,K., Nishioka,J., Kusumoto,H. and Hashimoto,S.
    Mechanism of inhibition of activated protein C by protein C inhibitor
    J Biochem (1984) 95, 187-195. PubMed  Europe PubMed
  112. [YEAR:25-2-1984]Villanueva,G.B.
    Predictions of the secondary structure of antithrombin III and the location of the heparin-binding site
    J Biol Chem (25-2-1984) 259, 2531-2536. PubMed  Europe PubMed
    113. 1983
  113. Bauer,K.A., Ashenhurst,J.B., Chediak,J. and Rosenberg,R.D.
    Antithrombin "Chicago": a functionally abnormal molecule with increased heparin affinity causing familial thrombophilia
    Blood (1983) 62, 1242-1250. PubMed  Europe PubMed
  114. [YEAR:25-10-1983]Chandra,T., Stackhouse,R., Kidd,V.J., Robson,K.J. and Woo,S.L.
    Sequence homology between human alpha 1-antichymotrypsin, alpha 1-antitrypsin, and antithrombin III
    Biochemistry (25-10-1983) 22, 5055-5061. PubMed  Europe PubMed
  115. Chandra,T., Stackhouse,R., Kidd,V.J. and Woo,S.L.
    Isolation and sequence characterization of a cDNA clone of human antithrombin III
    Proc Natl Acad Sci U S A (1983) 80, 1845-1848. PubMed  Europe PubMed  PMC  EPMC
  116. [YEAR:31-10-1983]Choay,J., Petitou,M., Lormeau,J.C., Sinay,P., Casu,B. and Gatti,G.
    Structure-activity relationship in heparin: a synthetic pentasaccharide with high affinity for antithrombin III and eliciting high anti-factor Xa activity
    Biochem Biophys Res Commun (31-10-1983) 116, 492-499. PubMed  Europe PubMed
  117. Conard,J., Brosstad,F., Lie Larsen,M., Samama,M. and Abildgaard,U.
    Molar antithrombin concentration in normal human plasma
    Haemostasis (1983) 13, 363-368. PubMed  Europe PubMed
  118. [YEAR:1-8-1983]Danielsson,A. and Bjork,I.
    Properties of antithrombin-thrombin complex formed in the presence and in the absence of heparin
    Biochem J (1-8-1983) 213, 345-353. PubMed  Europe PubMed  PMC  EPMC
  119. [YEAR:15-2-1983]Ferguson,W.S. and Finlay,T.H.
    Localization of the disulfide bond in human antithrombin III required for heparin-accelerated thrombin inactivation
    Arch Biochem Biophys (15-2-1983) 221, 304-307. PubMed  Europe PubMed
  120. Ferguson,W.S. and Finlay,T.H.
    Formation and stability of the complex formed between human antithrombin-III and thrombin
    Arch Biochem Biophys (1983) 220, 301-308. PubMed  Europe PubMed
  121. Jordan,R.E.
    Antithrombin in vertebrate species: conservation of the heparin-dependent anticoagulant mechanism
    Arch Biochem Biophys (1983) 227, 587-595. PubMed  Europe PubMed
  122. [YEAR:10-12-1983]Nesheim,M.E.
    A simple rate law that describes the kinetics of the heparin-catalyzed reaction between antithrombin III and thrombin
    J Biol Chem (10-12-1983) 258, 14708-14717. PubMed  Europe PubMed
  123. [YEAR:25-1-1983]Pletcher,C.H. and Nelsestuen,G.L.
    Two-substrate reaction model for the heparin-catalyzed bovine antithrombin/protease reaction
    J Biol Chem (25-1-1983) 258, 1086-1091. PubMed  Europe PubMed
  124. [YEAR:10-7-1983]Prochownik,E.V., Markham,A.F. and Orkin,S.H.
    Isolation of a cDNA clone for human antithrombin III
    J Biol Chem (10-7-1983) 258, 8389-8394. PubMed  Europe PubMed
  125. [YEAR:25-1-1983]Stackhouse,R., Chandra,T., Robson,K.J. and Woo,S.L.
    Purification of antithrombin III mRNA and cloning of its cDNA
    J Biol Chem (25-1-1983) 258, 703-706. PubMed  Europe PubMed
  126. [YEAR:25-9-1983]Villanueva,G.B. and Allen,N.
    Demonstration of a two-domain structure of antithrombin III during its denaturation in guanidinium chloride
    J Biol Chem (25-9-1983) 258, 11010-11013. PubMed  Europe PubMed
  127. [YEAR:25-11-1983]Villanueva,G.B. and Allen,N.
    Refolding properties of antithrombin III. Mechanism of binding to heparin
    J Biol Chem (25-11-1983) 258, 14048-14053. PubMed  Europe PubMed
  128. [YEAR:16-8-1983]Wong,R.F., Windwer,S.R. and Feinman,R.D.
    Interaction of thrombin and antithrombin. Reaction observed by intrinsic fluorescence measurements
    Biochemistry (16-8-1983) 22, 3994-3999. PubMed  Europe PubMed
    129. 1982
  129. [YEAR:29-10-1982]Bjork,I. and Lindahl,U.
    Mechanism of the anticoagulant action of heparin
    Mol Cell Biochem (29-10-1982) 48, 161-182. PubMed  Europe PubMed
  130. [YEAR:10-3-1982]Bjork,I., Jackson,C.M., Jornvall,H., Lavine,K.K., Nordling,K. and Salsgiver,W.J.
    The active site of antithrombin. Release of the same proteolytically cleaved form of the inhibitor from complexes with factor IXa, factor Xa, and thrombin
    J Biol Chem (10-3-1982) 257, 2406-2411. PubMed  Europe PubMed
  131. [YEAR:25-8-1982]Bjork,I. and Fish,W.W.
    Production in vitro and properties of a modified form of bovine antithrombin, cleaved at the active site by thrombin
    J Biol Chem (25-8-1982) 257, 9487-9493. PubMed  Europe PubMed
  132. [YEAR:21-6-1982]Bjork,I., Larm,O., Lindahl,U., Nordling,K. and Riquelme,M.E.
    Permanent activation of antithrombin by covalent attachment of heparin oligosaccharides
    FEBS Lett (21-6-1982) 143, 96-100. PubMed  Europe PubMed DOI
  133. [YEAR:20-12-1982]Bock,S.C., Wion,K.L., Vehar,G.A. and Lawn,R.M.
    Cloning and expression of the cDNA for human antithrombin III
    Nucleic Acids Res (20-12-1982) 10, 8113-8125. PubMed  Europe PubMed  PMC  EPMC
  134. [YEAR:1-7-1982]Carlson,T.H. and Atencio,A.C.
    Isolation and partial characterization of two distinct types of antithrombin III from rabbit
    Thromb Res (1-7-1982) 27, 23-34. PubMed  Europe PubMed
  135. [YEAR:1-10-1982]Danielsson,A. and Bjork,I.
    Mechanism of inactivation of trypsin by antithrombin
    Biochem J (1-10-1982) 207, 21-28. PubMed  Europe PubMed  PMC  EPMC
  136. [YEAR:1-2-1982]Griffith,M.J.
    Measurement of the heparin enhanced-antithrombin III/thrombin reaction rate in the presence of synthetic substrate
    Thromb Res (1-2-1982) 25, 245-253. PubMed  Europe PubMed
  137. [YEAR:10-12-1982]Griffith,M.J.
    The heparin-enhanced antithrombin III/thrombin reaction is saturable with respect to both thrombin and antithrombin III
    J Biol Chem (10-12-1982) 257, 13899-13302. PubMed  Europe PubMed
  138. Koide,T., Ohta,Y., Odani,S. and Ono,T.
    Chicken antithrombin. Isolation, characterization, and comparison with mammalian antithrombins and chicken ovalbumin
    J Biochem (1982) 91, 1223-1229. PubMed  Europe PubMed
  139. [YEAR:25-12-1982]Olson,S.T. and Shore,J.D.
    Demonstration of a two-step reaction mechanism for inhibition of alpha-thrombin by antithrombin III and identification of the step affected by heparin
    J Biol Chem (25-12-1982) 257, 14891-14895. PubMed  Europe PubMed
  140. [YEAR:1-5-1982]Sorensen,P.J., Sas,G., Peto,I., Blasko,G., Kremmer,T. and Samu,A.
    Distinction of two pathologic antithrombin III molecules: antithrombin III "Aalborg' and antithrombin III "Budapest'
    Thromb Res (1-5-1982) 26, 211-219. PubMed  Europe PubMed
  141. [YEAR:1-3-1982]Thunberg,L., Backstrom,G. and Lindahl,U.
    Further characterization of the antithrombin-binding sequence in heparin
    Carbohydr Res (1-3-1982) 100, 393-410. PubMed  Europe PubMed
  142. [YEAR:5-1-1982]Wong,R.F., Chang,T.L. and Feinman,R.D.
    Reaction of antithrombin with proteases. Nature of the reaction with trypsin
    Biochemistry (5-1-1982) 21, 6-12. PubMed  Europe PubMed
    143. 1981
  143. [YEAR:20-4-1981]Bjork,I., Danielsson,A., Fenton,J.W. and Jornvall
    The site in human antithrombin for functional proteolytic cleavage by human thrombin
    FEBS Lett (20-4-1981) 126, 257-260. PubMed  Europe PubMed DOI
  144. [YEAR:6-1-1981]Griffith,M.J. and Lundblad,R.L.
    Dissociation of antithrombin III-thrombin complex. Formation of active and inactive antithrombin III
    Biochemistry (6-1-1981) 20, 105-110. PubMed  Europe PubMed
  145. [YEAR:1-2-1981]Holmer,E., Kurachi,K. and Soderstrom,G.
    The molecular-weight dependence of the rate-enhancing effect of heparin on the inhibition of thrombin, factor Xa, factor IXa, factor XIa, factor XIIa and kallikrein by antithrombin
    Biochem J (1-2-1981) 193, 395-400. PubMed  Europe PubMed  PMC  EPMC
  146. Jochum,M., Lander,S., Heimburger,N. and Fritz,H.
    Effect of human granulocytic elastase on isolated human antithrombin III
    Hoppe Seylers Z Physiol Chem (1981) 362, 103-112. PubMed  Europe PubMed
  147. [YEAR:22-12-1981]Kress,L.F. and Catanese,J.J.
    Identification of the cleavage sites resulting from enzymatic inactivation of human antithrombin III by Crotalus adamanteus proteinase II in the the presence and absence of heparin
    Biochemistry (22-12-1981) 20, 7432-7438. PubMed  Europe PubMed
  148. Marciniak,E.
    Thrombin-induced proteolysis of human antithrombin III: an outstanding contribution of heparin
    Br J Haematol (1981) 48, 325-336. PubMed  Europe PubMed
  149. [YEAR:5-2-1981]Nordenman,B. and Bjork,I.
    Influence of ionic strength and pH on the interaction between high-affinity heparin and antithrombin
    Biochim Biophys Acta (5-2-1981) 672, 227-238. PubMed  Europe PubMed
  150. [YEAR:10-11-1981]Olson,S.T., Srinivasan,K.R., Bjork,I. and Shore,J.D.
    Binding of high affinity heparin to antithrombin III. Stopped flow kinetic studies of the binding interaction
    J Biol Chem (10-11-1981) 256, 11073-11079. PubMed  Europe PubMed
  151. [YEAR:1-5-1981]Shapiro,M.E., Rodvien,R., Bauer,K.A. and Salzman,E.W.
    Acute aortic thrombosis in antithrombin III deficiency
    JAMA (1-5-1981) 245, 1759-1761. PubMed  Europe PubMed DOI
  152. [YEAR:1-6-1981]Wallgren,P., Nordling,K. and Bjork,I.
    Immunological evidence for a proteolytic cleavage at the active site of antithrombin in the mechanism of inhibition of coagulation serine proteases
    Eur J Biochem (1-6-1981) 116, 493-496. PubMed  Europe PubMed
    153. 1980
  153. [YEAR:10-2-1980]Blackburn,M.N. and Sibley,C.C.
    The heparin binding site of antithrombin III. Evidence for a critical tryptophan residue
    J Biol Chem (10-2-1980) 255, 824-826. PubMed  Europe PubMed
  154. Carrell,R.W., Boswell,D.R., Brennan,S.O. and Owen,M.C.
    Active site of alpha1-antitrypsin: homologous site in antithrombin-III
    Biochem Biophys Res Commun (1980) 93, 399-402. PubMed  Europe PubMed
  155. [YEAR:6-10-1980]Danielsson,A. and Bjork,I.
    Slow, spontaneous dissociation of the antithrombin-thrombin complex produces a proteolytically modified form of the inhibitor
    FEBS Lett (6-10-1980) 119, 241-244. PubMed  Europe PubMed DOI
  156. [YEAR:10-6-1980]Franzen,L.E., Svensson,S. and Larm,O.
    Structural studies on the carbohydrate portion of human antithrombin III
    J Biol Chem (10-6-1980) 255, 5090-5093. PubMed  Europe PubMed
  157. [YEAR:1-9-1980]Longas,M.O. and Finlay,T.H.
    The covalent nature of the human antithrombin III-thrombin bond
    Biochem J (1-9-1980) 189, 481-489. PubMed  Europe PubMed  PMC  EPMC
  158. [YEAR:1-2-1980]Machovich,R., Regoeczi,E. and Hatton,M.W.
    Altered inactivation of trinitrophenylated thrombin by antithrombin III in the presence of heparin
    Thromb Res (1-2-1980) 17, 383-391. PubMed  Europe PubMed
  159. Mahoney,W.C., Kurachi,K. and Hermodson,M.A.
    Formation and dissociation of the covalent complexes between trypsin and two homologous inhibitors, alpha 1-antitrypsin and antithrombin III
    Eur J Biochem (1980) 105, 545-552. PubMed  Europe PubMed
  160. Mizuochi,T., Fujii,J., Kurachi,K. and Kobata,A.
    Structural studies of the carbohydrate moiety of human antithrombin III
    Arch Biochem Biophys (1980) 203, 458-465. PubMed  Europe PubMed
  161. [YEAR:1-4-1980]Murano,G., Williams,L., Miller-Andersson,M., Aronson,D.L. and King,C.
    Some properties of antithrombin-III and its concentration in human plasma
    Thromb Res (1-4-1980) 18, 259-262. PubMed  Europe PubMed
  162. [YEAR:18-6-1980]Sas,G., Peto,I., Banhegyi,D., Blasko,G. and Domjan,G.
    Heterogeneity of the "classical" antithrombin III deficiency
    Thromb Haemost (18-6-1980) 43, 133-136. PubMed  Europe PubMed
  163. [YEAR:31-10-1980]Tran,T.H., Bounameaux,H., Bondeli,C., Honkanen,H., Marbet,G.A. and Duckert,F.
    Purification and partial characterization of a hereditary abnormal antithrombin III fraction of a patient with recurrent thrombophlebitis
    Thromb Haemost (31-10-1980) 44, 87-91. PubMed  Europe PubMed
  164. Valeri,A.M., Wilson,S.M. and Feinman,R.D.
    Reaction of antithrombin with proteases. Evidence for a specific reaction with papain
    Biochim Biophys Acta (1980) 614, 526-533. PubMed  Europe PubMed
    165. 1979
  165. [YEAR:23-11-1979]Arko,F.R., Jewell,C.T., Dainer,P. and MacLeod,W.A.
    Primary mesenteric vein thrombosis associated with antithrombin III deficiency
    JAMA (23-11-1979) 242, 2324-2325. PubMed  Europe PubMed DOI
  166. [YEAR:17-12-1979]Bjork,I. and Nordling,K.
    Evidence by chemical modification for the involvement of one or more tryptophanyl residues of bovine antithrombin in the binding of high-affinity heparin
    Eur J Biochem (17-12-1979) 102, 497-502. PubMed  Europe PubMed
  167. [YEAR:14-12-1979]Carrell,R., Owen,M., Brennan,S. and Vaughan,L.
    Carboxy terminal fragment of human alpha-1-antitrypsin from hydroxylamine cleavage: homology with antithrombin III
    Biochem Biophys Res Commun (14-12-1979) 91, 1032-1037. PubMed  Europe PubMed
  168. [YEAR:1-11-1979]Fish,W.W. and Bjork,I.
    Release of a two-chain form of antithrombin from the antithrombin-thrombin complex
    Eur J Biochem (1-11-1979) 101, 31-38. PubMed  Europe PubMed
  169. [YEAR:1-2-1979]Fish,W.W., Orre,K. and Bjork,I.
    The production of an inactive form of antithrombin through limited proteolysis by thrombin
    FEBS Lett (1-2-1979) 98, 103-106. PubMed  Europe PubMed DOI
  170. [YEAR:10-12-1979]Griffith,M.J.
    Kinetic analysis of the heparin-enhanced antithrombin III/thrombin reaction. Reaction rate enhancement by heparin-thrombin association
    J Biol Chem (10-12-1979) 254, 12044-12049. PubMed  Europe PubMed
  171. [YEAR:25-2-1979]Jesty,J.
    Dissociation of complexes and their derivatives formed during inhibition of bovine thrombin and activated factor X by antithrombin III
    J Biol Chem (25-2-1979) 254, 1044-1049. PubMed  Europe PubMed
  172. [YEAR:25-10-1979]Jesty,J.
    The kinetics of formation and dissociation of the bovine thrombin.antithrombin III complex
    J Biol Chem (25-10-1979) 254, 10044-10050. PubMed  Europe PubMed
  173. [YEAR:15-10-1979]Jornvall,H., Fish,W.W. and Bjork,I.
    The thrombin cleavage site in bovine antithrombin
    FEBS Lett (15-10-1979) 106, 358-362. PubMed  Europe PubMed DOI
  174. Koide,T.
    Isolation and characterization of antithrombin III from human, porcine and rabbit plasma, and rat serum
    J Biochem (1979) 86, 1841-1850. PubMed  Europe PubMed
  175. [YEAR:6-3-1979]Villanueva,G. and Danishefsky,I.
    Conformational changes accompanying the binding of antithrombin III to thrombin
    Biochemistry (6-3-1979) 18, 810-817. PubMed  Europe PubMed
    176. 1978
  176. [YEAR:15-1-1978]Jesty,J.
    The inhibition of activated bovine coagulation factors X and VII by antithrombin III
    Arch Biochem Biophys (15-1-1978) 185, 165-173. PubMed  Europe PubMed
  177. Machovich,R., Staub,M. and Patthy,L.
    Decreased heparin sensitivity of cycholhexanedione-modified thrombin
    Eur J Biochem (1978) 83, 473-477. PubMed  Europe PubMed
  178. [YEAR:15-9-1978]Nordenman,B., Danielsson,A. and Bjork,I.
    The binding of low-affinity and high-affinity heparin to antithrombin. Fluorescence studies
    Eur J Biochem (15-9-1978) 90, 1-6. PubMed  Europe PubMed
  179. [YEAR:21-7-1978]Pomerantz,M.W. and Owen,W.G.
    A catalytic role for heparin. Evidence for a ternary complex of heparin cofactor thrombin and heparin
    Biochim Biophys Acta (21-7-1978) 535, 66-77. PubMed  Europe PubMed
    180. 1977
  180. Collen,D., Schetz,J., De Cock,F., Holmer,E. and Verstraete,M.
    Metabolism of antithrombin III (heparin cofactor) in man: effects of venous thrombosis and of heparin administration
    Eur J Clin Invest (1977) 7, 27-35. PubMed  Europe PubMed
  181. [YEAR:25-1-1977]Einarsson,R. and Andersson,L.O.
    Binding of heparin to human antithrombin III as studied by measurements of tryptophan fluorescence
    Biochim Biophys Acta (25-1-1977) 490, 104-111. PubMed  Europe PubMed
  182. [YEAR:15-8-1977]Nordenman,B., Nystrom,C. and Bjork,I.
    The size and shape of human and bovine antithrombin III
    Eur J Biochem (15-8-1977) 78, 195-203. PubMed  Europe PubMed
  183. [YEAR:24-1-1977]Villaneuva,G.B. and Danishefsky,I.
    Evidence for a heparin-induced conformational change on antithrombin III
    Biochem Biophys Res Commun (24-1-1977) 74, 803-809. PubMed  Europe PubMed
    184. 1976
  184. [YEAR:15-9-1976]Bjork,I. and Nordenman,B.
    Acceleration of the reaction between thrombin and antithrombin III by non-stoichiometric amounts of heparin
    Eur J Biochem (15-9-1976) 68, 507-511. PubMed  Europe PubMed
  185. [YEAR:27-1-1976]Kurachi,K., Fujikawa,K., Schmer,G. and Davie,E.W.
    Inhibition of bovine factor IXa and factor Xabeta by antithrombin III
    Biochemistry (27-1-1976) 15, 373-377. PubMed  Europe PubMed
  186. [YEAR:27-1-1976]Kurachi,K., Schmer,G., Hermodson,M.A., Teller,D.C. and Davie,E.W.
    Characterization of human, bovine, and horse antithrombin III
    Biochemistry (27-1-1976) 15, 368-373. PubMed  Europe PubMed
  187. Lahiri,B., Bagdasarian,A., Mitchell,B., Talamo,R.C. and Colman,R.W.
    Antithrombin-heparin cofactor: an inhibitor of plasma kallikrein
    Arch Biochem Biophys (1976) 175, 737-747. PubMed  Europe PubMed
  188. [YEAR:30-4-1976]Osterud,B., Miller-Andersson,M., Abildgaard,U. and Prydz,H.
    The effect of antithrombin III on the activity of the coagulation factors VII, IX and X
    Thromb Haemost (30-4-1976) 35, 295-304. PubMed  Europe PubMed
    189. 1975
  189. Thaler,E. and Schmer,G.
    A simple two-step isolation procedure for human and bovine antithrombin II/III (heparin cofactor): a comparison of two methods
    Br J Haematol (1975) 31, 233-243. PubMed  Europe PubMed
    190. 1974
  190. [YEAR:30-9-1974]Sas,G., Blasko,G., Banhegyi,D., Jako,J. and Palos,L.A.
    Abnormal antithrombin III (antithrombin III "Budapest") as a cause of a familial thrombophilia
    Thromb Diath Haemorrh (30-9-1974) 32, 105-115. PubMed  Europe PubMed
    191. 1973
  191. [YEAR:25-9-1973]Rosenberg,R.D. and Damus,P.S.
    The purification and mechanism of action of human antithrombin-heparin cofactor
    J Biol Chem (25-9-1973) 248, 6490-6505. PubMed  Europe PubMed
    192. 1969
  192. Abildgaard,U.
    Binding of thrombin to antithrombin III
    Scand J Clin Lab Invest (1969) 24, 23-27. PubMed  Europe PubMed
    193. 1965
  193. [YEAR:15-6-1965]Egeberg,O.
    Inherited antithrombin deficiency causing thrombophilia
    Thromb Diath Haemorrh (15-6-1965) 13, 516-530. PubMed  Europe PubMed
    194. 1913
  194. Collingwood,B.J. and MacMahon,M.T.
    The nature of thrombin and anti-thrombin
    J Physiol (1913) 47, 44-53. PubMed  Europe PubMed DOI

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