Merops Switch to
Peptidases

Inhibitor

Family Clan Small-molecule
inhibitor SEARCHES BLAST
MEROPS

Other
information

Literature for inhibitor I04.018: antithrombin

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Pharma

(Topics flags: S Structure, M Mutation, K Knockout, P Specificity, E Expression, U Therapeutic, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Hsu,E. and Moosavi,L.
    Biochemistry, Antithrombin III
     PubMed  Europe PubMed
  2. Hsu,E. and Moosavi,L.
    Biochemistry, Antithrombin III
     PubMed  Europe PubMed
    3. 2024
  3. Garrido-Rodriguez,P., Carmena-Bargueno,M., Morena-Barrio,M.E., Bravo-Perez,C., Morena-Barrio,B., Cifuentes-Riquelme,R., Lozano,M.L., Perez-Sanchez,H. and Corral,J.
    Analysis of AlphaFold and molecular dynamics structure predictions of mutations in serpins
    PLoS ONE19, e0304451-e0304451. PubMed  Europe PubMed DOI
  4. Saboor,M., Hamali,H.A., Mobarki,A.A., Madkhali,A.M. and Dboie,G.
    Exploring antithrombin: insights into its physiological features, clinical implications and analytical techniques
    Blood Coagul Fibrinolysis35, 43-48. PubMed  Europe PubMed DOI  V
    5. 2023
  5. Carvalho,T.
    siRNA against anti-thrombin reduces bleeding in hemophilia
    Nat Med29, 1288-1289. PubMed  Europe PubMed DOI
    6. 2021
  6. Gindele,R., Penzes-Daku,K., Balogh,G., Kallai,J., Bogati,R., Becsi,B., Erdodi,F., Katona,E. and Bereczky,Z.
    Investigation of the Differences in Antithrombin to Heparin Binding among Antithrombin Budapest 3, Basel, and Padua Mutations by Biochemical and In Silico Methods
    Biomolecules11, PubMed  Europe PubMed DOI
  7. Izaguirre,G., Swanson,R., Roth,R., Gettins,P.G.W. and Olson,S.T.
    Paramount Importance of Core Conformational Changes for Heparin Allosteric Activation of Antithrombin
    Biochemistry60, 1201-1213. PubMed  Europe PubMed DOI
    8. 2020
  8. Aymonnier,K., Kawecki,C., Arocas,V., Boulaftali,Y. and Bouton,M.C.
    Serpins, New Therapeutic Targets for Hemophilia
    Thromb Haemost PubMed  Europe PubMed DOI  V
  9. Boban,A. and Hermans,C.
    Safety of relaxing coagulation control by anti-TFPI in hemophilia patients: impact of tissue distribution of tissue factor
    J Thromb Haemost PubMed  Europe PubMed DOI
  10. de Laat-Kremers,R.M.W., Yan,Q., Ninivaggi,M., de Maat,M. and de Laat,B.
    Deciphering the coagulation profile through the dynamics of thrombin activity
    Sci Rep10, 12544-12544. PubMed  Europe PubMed DOI
  11. Krenzlin,H., Frenz,C., Schmitt,J., Masomi-Bornwasser,J., Wesp,D., Kalasauskas,D., Kerz,T., Lotz,J., Alessandri,B., Ringel,F. and Keric,N.
    High CSF thrombin concentration and activity is associated with an unfavorable outcome in patients with intracerebral hemorrhage
    PLoS ONE15, e0241565-e0241565. PubMed  Europe PubMed DOI
  12. Lu,Y., Villoutreix,B.O., Biswas,I., Ding,Q., Wang,X. and Rezaie,A.R.
    Thr90Ser Mutation in antithrombin is associated with recurrent thrombosis in a heterozygous carrier
    Thromb Haemost PubMed  Europe PubMed DOI  M
  13. Rezaie,A.R. and Giri,H.
    Anticoagulant and signaling functions of antithrombin
    J Thromb Haemost PubMed  Europe PubMed DOI  V
  14. Siritapetawee,J., Khunkaewla,P. and Thumanu,K.
    Roles of a protease from Euphorbia resinifera latex in human anticoagulant and antithrombotic activities
    Chem Biol Interact329, 109223-109223. PubMed  Europe PubMed DOI
    15. 2019
  15. Adams,B.M., Ke,H., Gierasch,L.M., Gershenson,A. and Hebert,D.N.
    Proper secretion of the serpin antithrombin relies strictly on thiol-dependent quality control
    J Biol Chem294, 18992-19011. PubMed  Europe PubMed DOI
  16. Rehman,S.U., Ashraf,S., Ahamad,S., Sarwar,T., Husain,M.A., Ahmad,P., Tabish,M. and Jairajpuri,M.A.
    Identification of a novel alternatively spliced isoform of antithrombin containing an additional RCL-like loop
    Biochem Biophys Res Commun517, 421-426. PubMed  Europe PubMed DOI
    17. 2018
  17. Amiral,J. and Seghatchian,J.
    Revisiting antithrombin in health and disease, congenital deficiencies and genetic variants, and laboratory studies on alpha and beta forms
    Transfus Apher Sci57, 291-297. PubMed  Europe PubMed DOI  V
  18. Arantes,P.R., Perez-Sanchez,H. and Verli,H.
    Antithrombin conformational modulation by D-myo-inositol 3,4,5,6-tetrakisphosphate (TMI), a novel scaffold for the development of antithrombotic agents
    J Biomol Struct Dyn36, 4045-4056. PubMed  Europe PubMed DOI
  19. Deshpande,R., Pathare,A., Alkindi,S., Al Zadjali,S., Ghosh,K. and Shetty,S.
    A novel p.Pro353His SERPINC1 mutation in the thrombin-binding region affecting stability of antithrombin molecule in an extended Omani family
    Int J Lab Hematol40, e49-e49. PubMed  Europe PubMed DOI  M
    20. 2017
  20. Aguila,S., Izaguirre,G., Martinez-Martinez,I., Vicente,V., Olson,S.T. and Corral,J.
    Disease-causing mutations in the serpin antithrombin reveal a key domain critical for inhibiting protease activities
    J Biol Chem292, 16513-16520. PubMed  Europe PubMed DOI  M
  21. Verhamme,I.M.
    A novel antithrombin domain dictates the journey's end of a proteinase
    J Biol Chem292, 16521-16522. PubMed  Europe PubMed DOI  M
    22. 2016
  22. Chandrasekhar,K., Ke,H., Wang,N., Goodwin,T., Gierasch,L.M., Gershenson,A. and Hebert,D.N.
    Cellular folding pathway of a metastable serpin
    Proc Natl Acad Sci U S A113, 6484-6489. PubMed  Europe PubMed DOI
  23. Luengo-Gil,G., Calvo,M.I., Martin-Villar,E., Aguila,S., Bohdan,N., Anton,A.I., Espin,S., Ayala de la Pena,F., Vicente,V., Corral,J., Quintanilla,M. and Martinez-Martinez,I.
    Antithrombin controls tumor migration, invasion and angiogenesis by inhibition of enteropeptidase
    Sci Rep6, 27544-27544. PubMed  Europe PubMed DOI
  24. Su,J., Shu,L., Zhang,Z., Cai,L., Zhang,X., Zhai,Y. and Liu,J.
    A small deletion in SERPINC1 causes type I antithrombin deficiency by promoting endoplasmic reticulum stress
    Oncotarget7, 76882-76890. PubMed  Europe PubMed DOI  M
    25. 2015
  25. Roth,R., Swanson,R., Izaguirre,G., Bock,S.C., Gettins,P.G. and Olson,S.T.
    Saturation mutagenesis of the antithrombin reactive center loop P14 residue supports a three-step mechanism of heparin allosteric activation involving intermediate and fully activated states
    J Biol Chem290, 28020-28036. PubMed  Europe PubMed DOI
  26. Toth,L., Fekete,A., Balogh,G., Bereczky,Z. and Komaromi,I.
    Dynamic properties of the native free antithrombin from molecular dynamics simulations: computational evidence for solvent-exposed Arg393 side chain
    J Biomol Struct Dyn33, 2023-2036. PubMed  Europe PubMed DOI
    27. 2014
  27. Izaguirre,G., Aguila,S., Qi,L., Swanson,R., Roth,R., Rezaie,A.R., Gettins,P.G. and Olson,S.T.
    Conformational activation of antithrombin by heparin involves an altered exosite interaction with protease
    J Biol Chem289, 34049-34064. PubMed  Europe PubMed DOI
  28. Yang,L., Dinarvand,P., Qureshi,S.H. and Rezaie,A.R.
    Engineering D-helix of antithrombin in alpha-1-proteinase inhibitor confers antiinflammatory properties on the chimeric serpin
    Thromb Haemost112, 164-175. PubMed  Europe PubMed DOI  E
    29. 2013
  29. Hepner,M. and Karlaftis,V.
    Antithrombin
    Methods Mol Biol992, 355-364. PubMed  Europe PubMed DOI  V
  30. Huntington,J.A.
    Thrombin inhibition by the serpins
    J Thromb Haemost11 Suppl 1, 254-264. PubMed  Europe PubMed DOI
  31. Talbot,K., Meixner,S.C. and Pryzdial,E.L.
    Proteolytic modulation of factor Xa-antithrombin complex enhances fibrinolysis in plasma
    Biochim Biophys Acta1834, 989-995. PubMed  Europe PubMed DOI
    32. 2012
  32. Asmal,M., Whitney,J.B., Luedemann,C., Carville,A., Steen,R., Letvin,N.L. and Geiben-Lynn,R.
    In vivo anti-HIV activity of the heparin-activated serine protease inhibitor antithrombin III encapsulated in lymph-targeting immunoliposomes
    PLoS ONE7, e48234-e48234. PubMed  Europe PubMed DOI  U
  33. Martinez-Martinez,I., Johnson,D.J., Yamasaki,M., Navarro-Fernandez,J., Ordonez,A., Vicente,V., Huntington,J.A. and Corral,J.
    Type II antithrombin deficiency caused by a large in-frame insertion: structural, functional and pathological relevance
    J Thromb Haemost10, 1859-1866. PubMed  Europe PubMed DOI  M
  34. Nakatomi,Y., Tsuji,M., Gokudan,S., Hanada-Dateki,T., Nakashima,T., Miyazaki,H., Hamamoto,T., Nakagaki,T. and Tomokiyo,K.
    Stable complex formation between serine protease inhibitor and zymogen: coagulation factor X cleaves the Arg393-Ser394 bond in a reactive centre loop of antithrombin in the presence of heparin
    J Biochem152, 463-470. PubMed  Europe PubMed DOI  P
  35. Olivieri,M., Bidlingmaier,C., Schetzeck,S., Borggrafe,I., Geisen,C. and Kurnik,K.
    Arterial thrombosis in homozygous antithrombin deficiency
    Hamostaseologie32 Suppl 1, S79-S82. PubMed  Europe PubMed  M
    36. 2011
  36. Chou,F.P., Xu,H., Lee,M.S., Chen,Y.W., Durand Richards,O.X., Swanson,R., Olson,S.T., Johnson,M.D. and Lin,C.Y.
    Matriptase is inhibited by extravascular antithrombin in epithelial cells but not in most carcinoma cells
    Am J Physiol Cell Physiol301, C1093-C1103. PubMed  Europe PubMed DOI
  37. Gierczak,R.F., Sutherland,J.S., Bhakta,V., Toltl,L.J., Liaw,P.C. and Sheffield,W.P.
    Retention of thrombin inhibitory activity by recombinant serpins expressed as integral membrane proteins tethered to the surface of mammalian cells
    J Thromb Haemost9, 2424-2435. PubMed  Europe PubMed DOI
  38. Huntington,J.A.
    Serpin structure, function and dysfunction
    J Thromb Haemost9 Suppl 1, 26-34. PubMed  Europe PubMed DOI  S
    39. 2010
  39. Johnson,D.J., Langdown,J. and Huntington,J.A.
    Molecular basis of factor IXa recognition by heparin-activated antithrombin revealed by a 1.7-A structure of the ternary complex
    Proc Natl Acad Sci U S A107, 645-650. PubMed  Europe PubMed DOI  S
  40. Martinez-Martinez,I., Ordonez,A., Navarro-Fernandez,J., Perez-Lara,A., Gutierrez-Gallego,R., Giraldo,R., Martinez,C., Llop,E., Vicente,V. and Corral,J.
    Antithrombin Murcia (K241E) causing antithrombin deficiency: a possible role for altered glycosylation
    Haematologica95, 1358-1365. PubMed  Europe PubMed DOI  M
  41. Yang,L., Manithody,C., Qureshi,S.H. and Rezaie,A.R.
    Role of the residues of the 39-loop in determining the substrate and inhibitor specificity of factor IXa
    J Biol Chem285, 28488-28495. PubMed  Europe PubMed DOI
  42. Yang,L., Manithody,C., Qureshi,S.H. and Rezaie,A.R.
    Inhibitory properties of the P1 Tyr variant of antithrombin
    Biochemistry49, 2680-2686. PubMed  Europe PubMed DOI
    43. 2009
  43. Langdown,J., Belzar,K.J., Savory,W.J., Baglin,T.P. and Huntington,J.A.
    The critical role of hinge-region expulsion in the induced-fit heparin binding mechanism of antithrombin
    J Mol Biol386, 1278-1289. PubMed  Europe PubMed DOI
  44. Mickowska,B.
    Purification and characterization of alpha(1)-proteinase inhibitor and antithrombin III: major serpins of rainbow trout (Oncorhynchuss mykiss) and carp (Cyprinus carpio) blood plasma
    Fish Physiol Biochem35, 231-240. PubMed  Europe PubMed DOI
  45. Yang,L., Qureshi,S.H., Manithody,C. and Rezaie,A.R.
    Role of P2 glycine in determining the specificity of antithrombin reaction with coagulation proteases
    Biochem Biophys Res Commun389, 162-167. PubMed  Europe PubMed DOI
    46. 2007
  46. Gonzales,P.R., Walston,T.D., Camacho,L.O., Kielar,D.M., Church,F.C., Rezaie,A.R. and Cooper,S.T.
    Mutation of the H-helix in antithrombin decreases heparin stimulation of protease inhibition
    Biochim Biophys Acta1774, 1431-1437. PubMed  Europe PubMed DOI
  47. Izaguirre,G., Swanson,R., Raja,S.M., Rezaie,A.R. and Olson,S.T.
    Mechanism by which exosites promote the inhibition of blood coagulation proteases by heparin-activated antithrombin
    J Biol Chem282, 33609-33622. PubMed  Europe PubMed DOI
  48. Kjellberg,M., Rimac,B. and Stenflo,J.
    An immunochemical method for quantitative determination of latent antithrombin, the reactive center loop-inserted uncleaved form of antithrombin
    J Thromb Haemost5, 127-132. PubMed  Europe PubMed DOI
    49. 2006
  49. [YEAR:3-5-2006]Johnson,D.J., Li,W., Adams,T.E. and Huntington,J.A.
    Antithrombin-S195A factor Xa-heparin structure reveals the allosteric mechanism of antithrombin activation
    EMBO J25, 2029-2037. PubMed  Europe PubMed DOI  S
  50. [YEAR:13-9-2006]Johnson,D.J., Langdown,J., Li,W., Luis,S.A., Baglin,T.P. and Huntington,J.A.
    Crystal structure of monomeric native antithrombin reveals a novel reactive center loop conformation
    J Biol Chem281, 35478-35486. PubMed  Europe PubMed DOI  S
  51. [YEAR:25-4-2006]Rezaie,A.R.
    Pentasaccharide enhances the inactivation of factor Xa by antithrombin by promoting the assembly of a Michaelis-type intermediate complex. Demonstration by rapid kinetic, surface plasmon resonance, and competitive binding studies
    Biochemistry45, 5324-5329. PubMed  Europe PubMed DOI
    52. 2005
  52. [YEAR:24-2-2005]Monien,B.H. and Desai,U.R.
    Antithrombin activation by nonsulfated, non-polysaccharide organic polymer
    J Med Chem48, 1269-1273. PubMed  Europe PubMed DOI
  53. Picard,V., Bauters,A., Khairy,M., Ochat,N., Jude,B., Aiach,M. and Alhenc-Gelas,M.
    Conformational Asn187Asp/Lys antithrombin variants and thrombosis. Clinical and biological features in 13 new heterozygotes
    Thromb Haemost93, 57-62. PubMed  Europe PubMed DOI
  54. Wang,W.B., Fu,Q.H., Ding,Q.L., Zhou,R.F., Wu,W.M., Hu,Y.Q., Wang,X.F., Yan,L.X., Wang,Z.Y. and Wang,H.L.
    Characterization of molecular defect of 13387-9delG mutated antithrombin in inherited type I antithrombin deficiency
    Blood Coagul Fibrinolysis16, 149-155. PubMed  Europe PubMed  M
    55. 2004
  55. Dementiev,A., Petitou,M., Herbert,J.M. and Gettins,P.G.
    The ternary complex of antithrombin-anhydrothrombin-heparin reveals the basis of inhibitor specificity
    Nat Struct Mol Biol11, 863-867. PubMed  Europe PubMed DOI  S
  56. [YEAR:6-2-2004]Johnson,D.J. and Huntington,J.A.
    The influence of hinge region residue Glu-381 on antithrombin allostery and metastability
    J Biol Chem279, 4913-4921. PubMed  Europe PubMed DOI
  57. Messmore,H.L., Wehrmacher,W.H., Coyne,E. and Fareed,J.
    Heparin to pentasaccharide and beyond: the end is not in sight
    Semin Thromb Hemost30 Suppl 1, 81-88. PubMed  Europe PubMed DOI
  58. Quinsey,N.S., Greedy,A.L., Bottomley,S.P., Whisstock,J.C. and Pike,R.N.
    Antithrombin: in control of coagulation
    Int J Biochem Cell Biol36, 386-389. PubMed  Europe PubMed DOI
  59. [YEAR:16-3-2004]Rezaie,A.R., Yang,L. and Manithody,C.
    Mutagenesis studies toward understanding the mechanism of differential reactivity of factor Xa with the native and heparin-activated antithrombin
    Biochemistry43, 2898-2905. PubMed  Europe PubMed DOI
  60. [YEAR:27-1-2004]Schedin-Weiss,S., Desai,U.R., Bock,S.C., Olson,S.T. and Bjork,I.
    Roles of N-terminal region residues Lys11, Arg13, and Arg24 of antithrombin in heparin recognition and in promotion and stabilization of the heparin-induced conformational change
    Biochemistry43, 675-683. PubMed  Europe PubMed DOI
  61. Taoka,Y., Okajima,K. and Uchiba,M.
    Antithrombin reduces compression-induced spinal cord injury in rats
    J Neurotrauma21, 1818-1830. PubMed  Europe PubMed DOI
  62. [YEAR:3-6-2004]Yang,L., Manithody,C. and Rezaie,A.R.
    Heparin-activated antithrombin interacts with the autolysis loop of target coagulation proteases
    Blood104, 1753-1759. PubMed  Europe PubMed DOI
    63. 2003
  63. [YEAR:26-9-2003]Dementiev,A., Simonovic,M., Volz,K. and Gettins,P.G.
    Canonical inhibitor-like interactions explain reactivity of alpha1-proteinase inhibitor Pittsburgh and antithrombin with proteinases
    J Biol Chem278, 37881-37887. PubMed  Europe PubMed DOI  M  S
  64. [YEAR:28-11-2003]Dewerchin,M., Herault,J.P., Wallays,G., Petitou,M., Schaeffer,P., Millet,L., Weitz,J.I., Moons,L., Collen,D., Carmeliet,P. and Herbert,J.M.
    Life-threatening thrombosis in mice with targeted Arg48-to-Cys mutation of the heparin-binding domain of antithrombin
    Circ Res93, 1120-1126. PubMed  Europe PubMed DOI
  65. Johnson,D.J. and Huntington,J.A.
    Crystal structure of antithrombin in a heparin-bound intermediate state
    Biochemistry42, 8712-8719. PubMed  Europe PubMed DOI  S
  66. Kremser,L., Bruckner,A., Heger,A., Grunert,T., Buchacher,A., Josic,D., Allmaier,G. and Rizzi,A.
    Characterization of antithrombin III from human plasma by two-dimensional gel electrophoresis and capillary electrophoretic methods
    Electrophoresis24, 4282-4290. PubMed  Europe PubMed DOI
  67. [YEAR:1-12-2003]Mushunje,A., Zhou,A., Carrell,R.W. and Huntington,J.A.
    Heparin-induced substrate behavior of antithrombin Cambridge II
    Blood102, 4028-4034. PubMed  Europe PubMed DOI
  68. Zhou,A., Stein,P.E., Huntington,J.A. and Carrell,R.W.
    Serpin polymerization is prevented by a hydrogen bond network that is centered on His-334 and stabilized by glycerol
    J Biol Chem278, 15116-15122. PubMed  Europe PubMed DOI  S
    69. 2002
  69. [YEAR:5-7-2002]Jairajpuri,M.A., Lu,A. and Bock,S.C.
    Elimination of P1 arginine 393 interaction with underlying glutamic acid 255 partially activates antithrombin III for thrombin inhibition but not factor Xa inhibition
    J Biol Chem277, 24460-24465. PubMed  Europe PubMed DOI
  70. [YEAR:3-5-2002]Quinsey,N.S., Whisstock,J.C., Le Bonniec,B., Louvain,V., Bottomley,S.P. and Pike,R.N.
    Molecular determinants of the mechanism underlying acceleration of the interaction between antithrombin and factor Xa by heparin pentasaccharide
    J Biol Chem277, 15971-15978. PubMed  Europe PubMed DOI
  71. [YEAR:8-10-2002]Rezaie,A.R.
    Insight into the molecular basis of coagulation proteinase specificity by mutagenesis of the serpin antithrombin
    Biochemistry41, 12179-12185. PubMed  Europe PubMed DOI
  72. Roemisch,J., Gray,E., Hoffmann,J.N. and Wiedermann,C.J.
    Antithrombin: a new look at the actions of a serine protease inhibitor
    Blood Coagul Fibrinolysis13, 657-670. PubMed  Europe PubMed DOI
  73. [YEAR:16-4-2002]Schedin-Weiss,S., Desai,U.R., Bock,S.C., Gettins,P.G., Olson,S.T. and Bjork,I.
    Importance of lysine 125 for heparin binding and activation of antithrombin
    Biochemistry41, 4779-4788. PubMed  Europe PubMed DOI
    74. 2001
  74. [YEAR:5-6-2001]Futamura,A., Beechem,J.M. and Gettins,P.G.W.
    Conformational equilibrium of the reactive center loop of antithrombin examined by steady state and time-resolved fluorescence measurements: Consequences for the mechanism of factor Xa inhibition by antithrombin-heparin complexes
    Biochemistry40, 6680-6687. PubMed  Europe PubMed DOI
    75. 2000
  75. Hopkins,P.C.R., Pike,R.N. and Stone,S.R.
    Evolution of serpin specificity: cooperative interactions in the reactive-site loop sequence of antithrombin specifically restrict the inhibition of activated protein C
    J Mol Evol51, 507-515. PubMed  Europe PubMed
  76. Huntington,J.A., McCoy,A., Belzar,K.J., Pei,X.Y., Gettins,P.G. and Carrell,R.W.
    The conformational activation of antithrombin. A 2.85-A structure of a fluorescein derivative reveals an electrostatic link between the hinge and heparin binding regions
    J Biol Chem275, 15377-15383. PubMed  Europe PubMed DOI  S
  77. Ishiguro,K., Kojima,T., Kadomatsu,K., Nakayama,Y., Takagi,A., Suzuki,M., Takeda,N., Ito,M., Yamamoto,K., Matsushita,T., Kusugami,K., Muramatsu,T. and Saito,H.
    Complete antithrombin deficiency in mice results in embryonic lethality
    J Clin Invest106, 873-878. PubMed  Europe PubMed DOI  K
    78. 1998
  78. [YEAR:1-11-1998]Bjork,I., Nordling,K., Raub-Segall,E., Hellman,U. and Olson,S.T.
    Inactivation of papain by antithrombin due to autolytic digestion: a model of serpin inactivation of cysteine proteinases
    Biochem J335, 701-709. PubMed  Europe PubMed
  79. [YEAR:10-3-1998]Huntington,J.A. and Gettins,P.G.
    Conformational conversion of antithrombin to a fully activated substrate of factor Xa without need for heparin
    Biochemistry37, 3272-3277. PubMed  Europe PubMed DOI
  80. Skinner,R., Chang,W.S., Jin,L., Pei,X., Huntington,J.A., Abrahams,J.P., Carrell,R.W. and Lomas,D.A.
    Implications for function and therapy of a 2.9 A structure of binary-complexed antithrombin
    J Mol Biol283, 9-14. PubMed  Europe PubMed DOI  S
    81. 1997
  81. Jin,L., Abrahams,J.P., Skinner,R., Petitou,M., Pike,R.N. and Carrell,R.W.
    The anticoagulant activation of antithrombin by heparin
    Proc Natl Acad Sci U S A94, 14683-14688. PubMed  Europe PubMed DOI  S
  82. Skinner,R., Abrahams,J.P., Whisstock,J.C., Lesk,A.M., Carrell,R.W. and Wardell,M.R.
    The 2.6 A structure of antithrombin indicates a conformational change at the heparin binding site
    J Mol Biol266, 601-609. PubMed  Europe PubMed DOI  S
    83. 1994
  83. Perry,D.J.
    Antithrombin and its inherited deficiencies
    Blood Rev8, 37-55. PubMed  Europe PubMed DOI  V
    84. 1993
  84. [YEAR:1-9-1993]Broze,G.J., Jr., Likert,K. and Higuchi,D.
    Inhibition of factor VIIa/tissue factor by antithrombin III and tissue factor pathway inhibitor
    Blood82, 1679-1681. PubMed  Europe PubMed
  85. [YEAR:15-2-1993]Sheehan,J.P., Wu,Q., Tollefsen,D.M. and Sadler,J.E.
    Mutagenesis of thrombin selectively modulates inhibition by serpins heparin cofactor II and antithrombin III. Interaction with the anion-binding exosite determines heparin cofactor II specificity
    J Biol Chem268, 3639-3645. PubMed  Europe PubMed
  86. Wardell,M.R., Abrahams,J.P., Bruce,D., Skinner,R. and Leslie,A.G.
    Crystallization and preliminary X-ray diffraction analysis of two conformations of intact human antithrombin
    J Mol Biol234, 1253-1258. PubMed  Europe PubMed DOI  S
    87. 1991
  87. Mast,A.E., Enghild,J.J., Nagase,H., Suzuki,K., Pizzo,S.V. and Salvesen,G.
    Kinetics and physiologic relevance of the inactivation of alpha1- proteinase inhibitor, alpha1-antichymotrypsin, and antithrombin III by matrix metalloproteinases-1 (tissue collagenase), -2 (72-kDa gelatinase/type IV collagenase), and -3 (stromelysin)
    J Biol Chem266, 15810-15816. PubMed  Europe PubMed
  88. Mejdoub,H., Le Ret,M., Boulanger,Y., Maman,M., Choay,J. and Reinbolt,J.
    The complete amino acid sequence of bovine antithrombin (ATIII)
    J Protein Chem10, 205-212. PubMed  Europe PubMed
    89. 1989
  89. [YEAR:25-6-1989]Jordan,R.E., Nelson,R.M., Kilpatrick,J., Newgren,J.O., Esmon,P.C. and Fournel,M.A.
    Inactivation of human antithrombin by neutrophil elastase. Kinetics of the heparin-dependent reaction
    J Biol Chem264, 10493-10500. PubMed  Europe PubMed
    90. 1986
  90. Bjork,I. and Danielsson,A.
    Antithrombin and related inhibitors of coagulation proteinases
    [ISSN:0-444-80763-2] (1986) 489-514.  V
    91. 1985
  91. [YEAR:24-10-1985]Carrell,R.W. and Owen,M.C.
    Plakalbumin, alpha 1-antitrypsin, antithrombin and the mechanism of inflammatory thrombosis
    Nature317, 730-732. PubMed  Europe PubMed
  92. [YEAR:12-3-1985]Fish,W.W., Danielsson,A., Nordling,K., Miller,S.H., Lam,C.F. and Bjork,I.
    Denaturation behavior of antithrombin in guanidinium chloride. Irreversibility of unfolding caused by aggregation
    Biochemistry24, 1510-1517. PubMed  Europe PubMed
  93. [YEAR:25-2-1985]Griffith,M.J., Noyes,C.M. and Church,F.C.
    Reactive site peptide structural similarity between heparin cofactor II and antithrombin III
    J Biol Chem260, 2218-2225. PubMed  Europe PubMed
  94. [YEAR:10-1-1985]Peterson,C.B. and Blackburn,M.N.
    Isolation and characterization of an antithrombin III variant with reduced carbohydrate content and enhanced heparin binding
    J Biol Chem260, 610-615. PubMed  Europe PubMed
    95. 1984
  95. Atha,D.H., Stephens,A.W. and Rosenberg,R.D.
    Evaluation of critical groups required for the binding of heparin to antithrombin
    Proc Natl Acad Sci U S A81, 1030-1034. PubMed  Europe PubMed
  96. [YEAR:25-1-1984]Blackburn,M.N., Smith,R.L., Carson,J. and Sibley,C.C.
    The heparin-binding site of antithrombin III. Identification of a critical tryptophan in the amino acid sequence
    J Biol Chem259, 939-941. PubMed  Europe PubMed
  97. Fuchs,H.E., Shifman,M.A., Michalopoulos,G. and Pizzo,S.V.
    Hepatocyte receptors for antithrombin III-proteinase complexes
    J Cell Biochem24, 197-206. PubMed  Europe PubMed DOI
  98. Fuchs,H.E., Michalopoulos,G.K. and Pizzo,S.V.
    Hepatocyte uptake of alpha 1-proteinase inhibitor-trypsin complexes in vitro: evidence for a shared uptake mechanism for proteinase complexes of alpha 1-proteinase inhibitor and antithrombin III
    J Cell Biochem25, 231-243. PubMed  Europe PubMed DOI
  99. [YEAR:10-6-1984]Gitel,S.N., Medina,V.M. and Wessler,S.
    Inhibition of human activated factor X by antithrombin III and alpha 1-proteinase inhibitor in human plasma
    J Biol Chem259, 6890-6895. PubMed  Europe PubMed
  100. [YEAR:10-5-1984]Hoylaerts,M., Owen,W.G. and Collen,D.
    Involvement of heparin chain length in the heparin-catalyzed inhibition of thrombin by antithrombin III
    J Biol Chem259, 5670-5677. PubMed  Europe PubMed
  101. [YEAR:15-5-1984]Jesty,J., Morrison,S.A. and Harpel,P.C.
    Measurement of human activated factor X-antithrombin complex by an enzyme-linked differential-antibody immunosorbent assay
    Anal Biochem139, 158-167. PubMed  Europe PubMed
  102. Kao,F.T., Morse,H.G., Law,M.L., Lidsky,A., Chandra,T. and Woo,S.L.
    Genetic mapping of the structural gene for antithrombin III to human chromosome 1
    Hum Genet67, 34-36. PubMed  Europe PubMed
  103. Karp,G.I., Marcum,J.A. and Rosenberg,R.D.
    The role of tryptophan residues in heparin-antithrombin interactions
    Arch Biochem Biophys233, 712-720. PubMed  Europe PubMed
  104. Koide,T., Odani,S., Takahashi,K., Ono,T. and Sakuragawa,N.
    Antithrombin III Toyama: replacement of arginine-47 by cysteine in hereditary abnormal antithrombin III that lacks heparin-binding ability
    Proc Natl Acad Sci U S A81, 289-293. PubMed  Europe PubMed  M
  105. [YEAR:25-10-1984]Lindahl,U., Thunberg,L., Backstrom,G., Riesenfeld,J., Nordling,K. and Bjork,I.
    Extension and structural variability of the antithrombin-binding sequence in heparin
    J Biol Chem259, 12368-12376. PubMed  Europe PubMed
  106. [YEAR:25-1-1984]Pecon,J.M. and Blackburn,M.N.
    Pyridoxylation of essential lysines in the heparin-binding site of antithrombin III
    J Biol Chem259, 935-938. PubMed  Europe PubMed
  107. [YEAR:15-2-1984]Rosenfeld,L. and Danishefsky,I.
    Effects of enzymatic deglycosylation on the biological activities of human thrombin and antithrombin
    Arch Biochem Biophys229, 359-367. PubMed  Europe PubMed
  108. Suzuki,K., Nishioka,J., Kusumoto,H. and Hashimoto,S.
    Mechanism of inhibition of activated protein C by protein C inhibitor
    J Biochem95, 187-195. PubMed  Europe PubMed
  109. [YEAR:25-2-1984]Villanueva,G.B.
    Predictions of the secondary structure of antithrombin III and the location of the heparin-binding site
    J Biol Chem259, 2531-2536. PubMed  Europe PubMed
    110. 1983
  110. Bauer,K.A., Ashenhurst,J.B., Chediak,J. and Rosenberg,R.D.
    Antithrombin "Chicago": a functionally abnormal molecule with increased heparin affinity causing familial thrombophilia
    Blood62, 1242-1250. PubMed  Europe PubMed
  111. Chandra,T., Stackhouse,R., Kidd,V.J. and Woo,S.L.
    Isolation and sequence characterization of a cDNA clone of human antithrombin III
    Proc Natl Acad Sci U S A80, 1845-1848. PubMed  Europe PubMed
  112. [YEAR:25-10-1983]Chandra,T., Stackhouse,R., Kidd,V.J., Robson,K.J. and Woo,S.L.
    Sequence homology between human alpha 1-antichymotrypsin, alpha 1-antitrypsin, and antithrombin III
    Biochemistry22, 5055-5061. PubMed  Europe PubMed
  113. [YEAR:31-10-1983]Choay,J., Petitou,M., Lormeau,J.C., Sinay,P., Casu,B. and Gatti,G.
    Structure-activity relationship in heparin: a synthetic pentasaccharide with high affinity for antithrombin III and eliciting high anti-factor Xa activity
    Biochem Biophys Res Commun116, 492-499. PubMed  Europe PubMed
  114. Conard,J., Brosstad,F., Lie Larsen,M., Samama,M. and Abildgaard,U.
    Molar antithrombin concentration in normal human plasma
    Haemostasis13, 363-368. PubMed  Europe PubMed
  115. [YEAR:1-8-1983]Danielsson,A. and Bjork,I.
    Properties of antithrombin-thrombin complex formed in the presence and in the absence of heparin
    Biochem J213, 345-353. PubMed  Europe PubMed
  116. Ferguson,W.S. and Finlay,T.H.
    Formation and stability of the complex formed between human antithrombin-III and thrombin
    Arch Biochem Biophys220, 301-308. PubMed  Europe PubMed
  117. [YEAR:15-2-1983]Ferguson,W.S. and Finlay,T.H.
    Localization of the disulfide bond in human antithrombin III required for heparin-accelerated thrombin inactivation
    Arch Biochem Biophys221, 304-307. PubMed  Europe PubMed
  118. Jordan,R.E.
    Antithrombin in vertebrate species: conservation of the heparin-dependent anticoagulant mechanism
    Arch Biochem Biophys227, 587-595. PubMed  Europe PubMed
  119. [YEAR:10-12-1983]Nesheim,M.E.
    A simple rate law that describes the kinetics of the heparin-catalyzed reaction between antithrombin III and thrombin
    J Biol Chem258, 14708-14717. PubMed  Europe PubMed
  120. [YEAR:25-1-1983]Pletcher,C.H. and Nelsestuen,G.L.
    Two-substrate reaction model for the heparin-catalyzed bovine antithrombin/protease reaction
    J Biol Chem258, 1086-1091. PubMed  Europe PubMed
  121. [YEAR:10-7-1983]Prochownik,E.V., Markham,A.F. and Orkin,S.H.
    Isolation of a cDNA clone for human antithrombin III
    J Biol Chem258, 8389-8394. PubMed  Europe PubMed
  122. [YEAR:25-1-1983]Stackhouse,R., Chandra,T., Robson,K.J. and Woo,S.L.
    Purification of antithrombin III mRNA and cloning of its cDNA
    J Biol Chem258, 703-706. PubMed  Europe PubMed
  123. [YEAR:25-11-1983]Villanueva,G.B. and Allen,N.
    Refolding properties of antithrombin III. Mechanism of binding to heparin
    J Biol Chem258, 14048-14053. PubMed  Europe PubMed
  124. [YEAR:25-9-1983]Villanueva,G.B. and Allen,N.
    Demonstration of a two-domain structure of antithrombin III during its denaturation in guanidinium chloride
    J Biol Chem258, 11010-11013. PubMed  Europe PubMed
  125. [YEAR:16-8-1983]Wong,R.F., Windwer,S.R. and Feinman,R.D.
    Interaction of thrombin and antithrombin. Reaction observed by intrinsic fluorescence measurements
    Biochemistry22, 3994-3999. PubMed  Europe PubMed
    126. 1982
  126. [YEAR:25-8-1982]Bjork,I. and Fish,W.W.
    Production in vitro and properties of a modified form of bovine antithrombin, cleaved at the active site by thrombin
    J Biol Chem257, 9487-9493. PubMed  Europe PubMed
  127. [YEAR:21-6-1982]Bjork,I., Larm,O., Lindahl,U., Nordling,K. and Riquelme,M.E.
    Permanent activation of antithrombin by covalent attachment of heparin oligosaccharides
    FEBS Lett143, 96-100. PubMed  Europe PubMed DOI
  128. [YEAR:29-10-1982]Bjork,I. and Lindahl,U.
    Mechanism of the anticoagulant action of heparin
    Mol Cell Biochem48, 161-182. PubMed  Europe PubMed
  129. [YEAR:10-3-1982]Bjork,I., Jackson,C.M., Jornvall,H., Lavine,K.K., Nordling,K. and Salsgiver,W.J.
    The active site of antithrombin. Release of the same proteolytically cleaved form of the inhibitor from complexes with factor IXa, factor Xa, and thrombin
    J Biol Chem257, 2406-2411. PubMed  Europe PubMed
  130. [YEAR:20-12-1982]Bock,S.C., Wion,K.L., Vehar,G.A. and Lawn,R.M.
    Cloning and expression of the cDNA for human antithrombin III
    Nucleic Acids Res10, 8113-8125. PubMed  Europe PubMed
  131. [YEAR:1-7-1982]Carlson,T.H. and Atencio,A.C.
    Isolation and partial characterization of two distinct types of antithrombin III from rabbit
    Thromb Res27, 23-34. PubMed  Europe PubMed
  132. [YEAR:1-10-1982]Danielsson,A. and Bjork,I.
    Mechanism of inactivation of trypsin by antithrombin
    Biochem J207, 21-28. PubMed  Europe PubMed
  133. [YEAR:10-12-1982]Griffith,M.J.
    The heparin-enhanced antithrombin III/thrombin reaction is saturable with respect to both thrombin and antithrombin III
    J Biol Chem257, 13899-13302. PubMed  Europe PubMed
  134. [YEAR:1-2-1982]Griffith,M.J.
    Measurement of the heparin enhanced-antithrombin III/thrombin reaction rate in the presence of synthetic substrate
    Thromb Res25, 245-253. PubMed  Europe PubMed
  135. Koide,T., Ohta,Y., Odani,S. and Ono,T.
    Chicken antithrombin. Isolation, characterization, and comparison with mammalian antithrombins and chicken ovalbumin
    J Biochem91, 1223-1229. PubMed  Europe PubMed
  136. [YEAR:25-12-1982]Olson,S.T. and Shore,J.D.
    Demonstration of a two-step reaction mechanism for inhibition of alpha-thrombin by antithrombin III and identification of the step affected by heparin
    J Biol Chem257, 14891-14895. PubMed  Europe PubMed
  137. [YEAR:1-5-1982]Sorensen,P.J., Sas,G., Peto,I., Blasko,G., Kremmer,T. and Samu,A.
    Distinction of two pathologic antithrombin III molecules: antithrombin III "Aalborg' and antithrombin III "Budapest'
    Thromb Res26, 211-219. PubMed  Europe PubMed
  138. [YEAR:1-3-1982]Thunberg,L., Backstrom,G. and Lindahl,U.
    Further characterization of the antithrombin-binding sequence in heparin
    Carbohydr Res100, 393-410. PubMed  Europe PubMed
  139. [YEAR:5-1-1982]Wong,R.F., Chang,T.L. and Feinman,R.D.
    Reaction of antithrombin with proteases. Nature of the reaction with trypsin
    Biochemistry21, 6-12. PubMed  Europe PubMed
    140. 1981
  140. [YEAR:20-4-1981]Bjork,I., Danielsson,A., Fenton,J.W. and Jornvall
    The site in human antithrombin for functional proteolytic cleavage by human thrombin
    FEBS Lett126, 257-260. PubMed  Europe PubMed DOI
  141. [YEAR:6-1-1981]Griffith,M.J. and Lundblad,R.L.
    Dissociation of antithrombin III-thrombin complex. Formation of active and inactive antithrombin III
    Biochemistry20, 105-110. PubMed  Europe PubMed
  142. [YEAR:1-2-1981]Holmer,E., Kurachi,K. and Soderstrom,G.
    The molecular-weight dependence of the rate-enhancing effect of heparin on the inhibition of thrombin, factor Xa, factor IXa, factor XIa, factor XIIa and kallikrein by antithrombin
    Biochem J193, 395-400. PubMed  Europe PubMed
  143. Jochum,M., Lander,S., Heimburger,N. and Fritz,H.
    Effect of human granulocytic elastase on isolated human antithrombin III
    Hoppe Seylers Z Physiol Chem362, 103-112. PubMed  Europe PubMed
  144. [YEAR:22-12-1981]Kress,L.F. and Catanese,J.J.
    Identification of the cleavage sites resulting from enzymatic inactivation of human antithrombin III by Crotalus adamanteus proteinase II in the the presence and absence of heparin
    Biochemistry20, 7432-7438. PubMed  Europe PubMed
  145. Marciniak,E.
    Thrombin-induced proteolysis of human antithrombin III: an outstanding contribution of heparin
    Br J Haematol48, 325-336. PubMed  Europe PubMed
  146. [YEAR:5-2-1981]Nordenman,B. and Bjork,I.
    Influence of ionic strength and pH on the interaction between high-affinity heparin and antithrombin
    Biochim Biophys Acta672, 227-238. PubMed  Europe PubMed
  147. [YEAR:10-11-1981]Olson,S.T., Srinivasan,K.R., Bjork,I. and Shore,J.D.
    Binding of high affinity heparin to antithrombin III. Stopped flow kinetic studies of the binding interaction
    J Biol Chem256, 11073-11079. PubMed  Europe PubMed
  148. [YEAR:1-5-1981]Shapiro,M.E., Rodvien,R., Bauer,K.A. and Salzman,E.W.
    Acute aortic thrombosis in antithrombin III deficiency
    JAMA245, 1759-1761. PubMed  Europe PubMed DOI
  149. [YEAR:1-6-1981]Wallgren,P., Nordling,K. and Bjork,I.
    Immunological evidence for a proteolytic cleavage at the active site of antithrombin in the mechanism of inhibition of coagulation serine proteases
    Eur J Biochem116, 493-496. PubMed  Europe PubMed
    150. 1980
  150. [YEAR:10-2-1980]Blackburn,M.N. and Sibley,C.C.
    The heparin binding site of antithrombin III. Evidence for a critical tryptophan residue
    J Biol Chem255, 824-826. PubMed  Europe PubMed
  151. Carrell,R.W., Boswell,D.R., Brennan,S.O. and Owen,M.C.
    Active site of alpha1-antitrypsin: homologous site in antithrombin-III
    Biochem Biophys Res Commun93, 399-402. PubMed  Europe PubMed
  152. [YEAR:6-10-1980]Danielsson,A. and Bjork,I.
    Slow, spontaneous dissociation of the antithrombin-thrombin complex produces a proteolytically modified form of the inhibitor
    FEBS Lett119, 241-244. PubMed  Europe PubMed DOI
  153. [YEAR:10-6-1980]Franzen,L.E., Svensson,S. and Larm,O.
    Structural studies on the carbohydrate portion of human antithrombin III
    J Biol Chem255, 5090-5093. PubMed  Europe PubMed
  154. [YEAR:1-9-1980]Longas,M.O. and Finlay,T.H.
    The covalent nature of the human antithrombin III-thrombin bond
    Biochem J189, 481-489. PubMed  Europe PubMed
  155. [YEAR:1-2-1980]Machovich,R., Regoeczi,E. and Hatton,M.W.
    Altered inactivation of trinitrophenylated thrombin by antithrombin III in the presence of heparin
    Thromb Res17, 383-391. PubMed  Europe PubMed
  156. Mahoney,W.C., Kurachi,K. and Hermodson,M.A.
    Formation and dissociation of the covalent complexes between trypsin and two homologous inhibitors, alpha 1-antitrypsin and antithrombin III
    Eur J Biochem105, 545-552. PubMed  Europe PubMed
  157. Mizuochi,T., Fujii,J., Kurachi,K. and Kobata,A.
    Structural studies of the carbohydrate moiety of human antithrombin III
    Arch Biochem Biophys203, 458-465. PubMed  Europe PubMed
  158. [YEAR:1-4-1980]Murano,G., Williams,L., Miller-Andersson,M., Aronson,D.L. and King,C.
    Some properties of antithrombin-III and its concentration in human plasma
    Thromb Res18, 259-262. PubMed  Europe PubMed
  159. [YEAR:18-6-1980]Sas,G., Peto,I., Banhegyi,D., Blasko,G. and Domjan,G.
    Heterogeneity of the "classical" antithrombin III deficiency
    Thromb Haemost43, 133-136. PubMed  Europe PubMed
  160. [YEAR:31-10-1980]Tran,T.H., Bounameaux,H., Bondeli,C., Honkanen,H., Marbet,G.A. and Duckert,F.
    Purification and partial characterization of a hereditary abnormal antithrombin III fraction of a patient with recurrent thrombophlebitis
    Thromb Haemost44, 87-91. PubMed  Europe PubMed
  161. Valeri,A.M., Wilson,S.M. and Feinman,R.D.
    Reaction of antithrombin with proteases. Evidence for a specific reaction with papain
    Biochim Biophys Acta614, 526-533. PubMed  Europe PubMed
    162. 1979
  162. [YEAR:23-11-1979]Arko,F.R., Jewell,C.T., Dainer,P. and MacLeod,W.A.
    Primary mesenteric vein thrombosis associated with antithrombin III deficiency
    JAMA242, 2324-2325. PubMed  Europe PubMed DOI
  163. [YEAR:17-12-1979]Bjork,I. and Nordling,K.
    Evidence by chemical modification for the involvement of one or more tryptophanyl residues of bovine antithrombin in the binding of high-affinity heparin
    Eur J Biochem102, 497-502. PubMed  Europe PubMed
  164. [YEAR:14-12-1979]Carrell,R., Owen,M., Brennan,S. and Vaughan,L.
    Carboxy terminal fragment of human alpha-1-antitrypsin from hydroxylamine cleavage: homology with antithrombin III
    Biochem Biophys Res Commun91, 1032-1037. PubMed  Europe PubMed
  165. [YEAR:1-2-1979]Fish,W.W., Orre,K. and Bjork,I.
    The production of an inactive form of antithrombin through limited proteolysis by thrombin
    FEBS Lett98, 103-106. PubMed  Europe PubMed DOI
  166. [YEAR:1-11-1979]Fish,W.W. and Bjork,I.
    Release of a two-chain form of antithrombin from the antithrombin-thrombin complex
    Eur J Biochem101, 31-38. PubMed  Europe PubMed
  167. [YEAR:10-12-1979]Griffith,M.J.
    Kinetic analysis of the heparin-enhanced antithrombin III/thrombin reaction. Reaction rate enhancement by heparin-thrombin association
    J Biol Chem254, 12044-12049. PubMed  Europe PubMed
  168. [YEAR:25-2-1979]Jesty,J.
    Dissociation of complexes and their derivatives formed during inhibition of bovine thrombin and activated factor X by antithrombin III
    J Biol Chem254, 1044-1049. PubMed  Europe PubMed
  169. [YEAR:25-10-1979]Jesty,J.
    The kinetics of formation and dissociation of the bovine thrombin.antithrombin III complex
    J Biol Chem254, 10044-10050. PubMed  Europe PubMed
  170. [YEAR:15-10-1979]Jornvall,H., Fish,W.W. and Bjork,I.
    The thrombin cleavage site in bovine antithrombin
    FEBS Lett106, 358-362. PubMed  Europe PubMed DOI
  171. Koide,T.
    Isolation and characterization of antithrombin III from human, porcine and rabbit plasma, and rat serum
    J Biochem86, 1841-1850. PubMed  Europe PubMed
  172. [YEAR:6-3-1979]Villanueva,G. and Danishefsky,I.
    Conformational changes accompanying the binding of antithrombin III to thrombin
    Biochemistry18, 810-817. PubMed  Europe PubMed
    173. 1978
  173. [YEAR:15-1-1978]Jesty,J.
    The inhibition of activated bovine coagulation factors X and VII by antithrombin III
    Arch Biochem Biophys185, 165-173. PubMed  Europe PubMed
  174. Machovich,R., Staub,M. and Patthy,L.
    Decreased heparin sensitivity of cycholhexanedione-modified thrombin
    Eur J Biochem83, 473-477. PubMed  Europe PubMed
  175. [YEAR:15-9-1978]Nordenman,B., Danielsson,A. and Bjork,I.
    The binding of low-affinity and high-affinity heparin to antithrombin. Fluorescence studies
    Eur J Biochem90, 1-6. PubMed  Europe PubMed
  176. [YEAR:21-7-1978]Pomerantz,M.W. and Owen,W.G.
    A catalytic role for heparin. Evidence for a ternary complex of heparin cofactor thrombin and heparin
    Biochim Biophys Acta535, 66-77. PubMed  Europe PubMed
    177. 1977
  177. Collen,D., Schetz,J., De Cock,F., Holmer,E. and Verstraete,M.
    Metabolism of antithrombin III (heparin cofactor) in man: effects of venous thrombosis and of heparin administration
    Eur J Clin Invest7, 27-35. PubMed  Europe PubMed
  178. [YEAR:25-1-1977]Einarsson,R. and Andersson,L.O.
    Binding of heparin to human antithrombin III as studied by measurements of tryptophan fluorescence
    Biochim Biophys Acta490, 104-111. PubMed  Europe PubMed
  179. [YEAR:15-8-1977]Nordenman,B., Nystrom,C. and Bjork,I.
    The size and shape of human and bovine antithrombin III
    Eur J Biochem78, 195-203. PubMed  Europe PubMed
  180. [YEAR:24-1-1977]Villaneuva,G.B. and Danishefsky,I.
    Evidence for a heparin-induced conformational change on antithrombin III
    Biochem Biophys Res Commun74, 803-809. PubMed  Europe PubMed
    181. 1976
  181. [YEAR:15-9-1976]Bjork,I. and Nordenman,B.
    Acceleration of the reaction between thrombin and antithrombin III by non-stoichiometric amounts of heparin
    Eur J Biochem68, 507-511. PubMed  Europe PubMed
  182. [YEAR:27-1-1976]Kurachi,K., Schmer,G., Hermodson,M.A., Teller,D.C. and Davie,E.W.
    Characterization of human, bovine, and horse antithrombin III
    Biochemistry15, 368-373. PubMed  Europe PubMed
  183. [YEAR:27-1-1976]Kurachi,K., Fujikawa,K., Schmer,G. and Davie,E.W.
    Inhibition of bovine factor IXa and factor Xabeta by antithrombin III
    Biochemistry15, 373-377. PubMed  Europe PubMed
  184. Lahiri,B., Bagdasarian,A., Mitchell,B., Talamo,R.C. and Colman,R.W.
    Antithrombin-heparin cofactor: an inhibitor of plasma kallikrein
    Arch Biochem Biophys175, 737-747. PubMed  Europe PubMed
  185. [YEAR:30-4-1976]Osterud,B., Miller-Andersson,M., Abildgaard,U. and Prydz,H.
    The effect of antithrombin III on the activity of the coagulation factors VII, IX and X
    Thromb Haemost35, 295-304. PubMed  Europe PubMed
    186. 1975
  186. Thaler,E. and Schmer,G.
    A simple two-step isolation procedure for human and bovine antithrombin II/III (heparin cofactor): a comparison of two methods
    Br J Haematol31, 233-243. PubMed  Europe PubMed
    187. 1974
  187. [YEAR:30-9-1974]Sas,G., Blasko,G., Banhegyi,D., Jako,J. and Palos,L.A.
    Abnormal antithrombin III (antithrombin III "Budapest") as a cause of a familial thrombophilia
    Thromb Diath Haemorrh32, 105-115. PubMed  Europe PubMed
    188. 1973
  188. [YEAR:25-9-1973]Rosenberg,R.D. and Damus,P.S.
    The purification and mechanism of action of human antithrombin-heparin cofactor
    J Biol Chem248, 6490-6505. PubMed  Europe PubMed
    189. 1969
  189. Abildgaard,U.
    Binding of thrombin to antithrombin III
    Scand J Clin Lab Invest24, 23-27. PubMed  Europe PubMed
    190. 1965
  190. [YEAR:15-6-1965]Egeberg,O.
    Inherited antithrombin deficiency causing thrombophilia
    Thromb Diath Haemorrh13, 516-530. PubMed  Europe PubMed
    191. 1913
  191. Collingwood,B.J. and MacMahon,M.T.
    The nature of thrombin and anti-thrombin
    J Physiol47, 44-53. PubMed  Europe PubMed DOI

feedback
Page created 8-September-2023

EMBL-EBI logo

© 2025 EBI
Terms of use