Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence Q96HC4

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
1	unknown peptidase	1-596	P		NT	<%Agarwal et al., 2012[]%>
83	trypsin 1	2-596	N		MS	Schilling & Overall, 2008
85	cathepsin K	83-97	N		MS	Schilling & Overall, 2008
97	trypsin 1	2-596	N		MS	Schilling & Overall, 2008
101	trypsin 1	2-596	N		MS	Schilling & Overall, 2008
116	trypsin 1	2-596	N		MS	Schilling & Overall, 2008
188	granzyme B (Homo sapiens-type)	2-596	N		MS	Van Damme et al., 2010
215	granzyme B (Homo sapiens-type)	2-596	N		MS	Van Damme et al., 2010
288	cathepsin B	285-296	N		MS	Biniossek et al., 2011
364	cathepsin L	360-375	N		MS	Biniossek et al., 2011