Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence Q92688

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
20	trypsin 1	1-251	N		MS	Schilling & Overall, 2008
28	trypsin 1	1-251	N		MS	Schilling & Overall, 2008
75	trypsin 1	1-251	N		MS	Schilling & Overall, 2008
77	cathepsin L	76-86	N		MS	Biniossek et al., 2011
86	trypsin 1	1-251	N		MS	Schilling & Overall, 2008
91	cathepsin L	87-99	N		MS	Biniossek et al., 2011
101	trypsin 1	1-251	N		MS	Schilling & Overall, 2008
110	trypsin 1	1-251	N		MS	Schilling & Overall, 2008
116	trypsin 1	1-251	N		MS	Schilling & Overall, 2008
132	trypsin 1	1-251	N		MS	Schilling & Overall, 2008
137	trypsin 1	1-251	N		MS	Schilling & Overall, 2008
150	trypsin 1	1-251	N		MS	Schilling & Overall, 2008
163	unknown peptidase	1-251	P		MS	Dix et al., 2008
219	granzyme B (Homo sapiens-type)	1-251	N		MS	Van Damme et al., 2010
221	granzyme B (Homo sapiens-type)	1-251	N		MS	Van Damme et al., 2010
222	granzyme B (Homo sapiens-type)	1-251	P		MS	Van Damme et al., 2009
225	unknown peptidase	1-251	P			Van Damme et al., 2009
228	granzyme B (Homo sapiens-type)	1-251	N		MS	Van Damme et al., 2010
230	granzyme B (Homo sapiens-type)	1-251	N		MS	Van Damme et al., 2010
240	trypsin 1	1-251	N			Van Damme et al., 2009