Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence Q16658

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
1	unknown peptidase	1-493	P		NT	<%Agarwal et al., 2012[]%>
71	cathepsin L	69-82	N		MS	Biniossek et al., 2011
71	cathepsin S	69-82	N		MS	Biniossek et al., 2011
90	trypsin 1	2-493	N		MS	Schilling & Overall, 2008
100	trypsin 1	2-493	N		MS	Schilling & Overall, 2008
118	trypsin 1	2-493	N		MS	Schilling & Overall, 2008
131	trypsin 1	2-493	N		MS	Schilling & Overall, 2008
167	trypsin 1	2-493	N		MS	Schilling & Overall, 2008
175	matrix metallopeptidase-2	167-185	N		MS	Schilling & Overall, 2008
185	trypsin 1	2-493	N		MS	Schilling & Overall, 2008
229	trypsin 1	2-493	N		MS	Schilling & Overall, 2008
241	trypsin 1	2-493	N		MS	Schilling & Overall, 2008
471	cathepsin L	461-480	N		MS	Biniossek et al., 2011