Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence Q15003

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
1	unknown peptidase	1-741	P	release of an initiating methionine	MS
39	matrix metallopeptidase-2	31-53	N		MS	Schilling & Overall, 2008
40	thrombin	31-53	N		MS	Schilling & Overall, 2008
53	glutamyl endopeptidase I	1-741	N		MS	Schilling & Overall, 2008
71	trypsin 1	1-741	N		MS	Schilling & Overall, 2008
83	trypsin 1	1-741	N		MS	Schilling & Overall, 2008
199	unknown peptidase		P		MS	Mahrus et al., 2008
338	matrix metallopeptidase-2	334-355	N		MS	Schilling & Overall, 2008
355	glutamyl endopeptidase I	1-741	N		MS	Schilling & Overall, 2008
366	unknown peptidase	1-741	P		MS	Dix et al., 2008