Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence Q14257

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
22	unknown peptidase	1-317	P	release of a signal peptide	MS	Van Damme P et al., 2005
25	unknown peptidase	1-317	P		NT	<%Agarwal et al., 2012[]%>
49	meprin alpha subunit	26-317	N		MS	Becker-Pauly et al., 2011
49	meprin beta subunit	26-317	N		MS	Becker-Pauly et al., 2011
68	matrix metallopeptidase-2	61-83	N		MS	Schilling & Overall, 2008
83	glutamyl endopeptidase I	23-317	N		MS	Schilling & Overall, 2008