Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence Q14103

,

Click here to display alignment and conservation of cleavage sites of this sequence with close homologues. This will take a few moments.

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
32	cathepsin L	1-57	N		MS	Biniossek et al., 2011
32	cathepsin S	1-67	N		MS	Biniossek et al., 2011
35	cathepsin L	1-67	N		MS	Biniossek et al., 2011
35	cathepsin S	1-67	N		MS	Biniossek et al., 2011
36	cathepsin S	1-67	N		MS	Biniossek et al., 2011
36	cathepsin B	1-67	N		MS	Biniossek et al., 2011
38	cathepsin L	1-77	N		MS	Biniossek et al., 2011
38	cathepsin S	1-68	N		MS	Biniossek et al., 2011
38	cathepsin B	1-67	N		MS	Biniossek et al., 2011
39	cathepsin S	1-68	N		MS	Biniossek et al., 2011
39	cathepsin B	1-67	N		MS	Biniossek et al., 2011
40	cathepsin S	1-67	N		MS	Biniossek et al., 2011
40	cathepsin B	1-67	N		MS	Biniossek et al., 2011
41	cathepsin B	1-67	N		MS	Biniossek et al., 2011
42	cathepsin S	1-67	N		MS	Biniossek et al., 2011
42	cathepsin B	1-67	N		MS	Biniossek et al., 2011
46	cathepsin B	1-67	N		MS	Biniossek et al., 2011
51	cathepsin S	1-67	N		MS	Biniossek et al., 2011
69	unknown peptidase		P		MS	Mahrus et al., 2008
71	unknown peptidase	1-355	P			Van Damme et al., 2009
85	trypsin 1	1-355	N			Van Damme et al., 2009
97	peptidyl-Lys metallopeptidase	1-355	N		MS
98	trypsin 1	1-355	N		MS	Schilling & Overall, 2008
99	cathepsin B	99-110	N		MS	Biniossek et al., 2011
102	cathepsin L	99-110	N		MS	Biniossek et al., 2011
110	trypsin 1	1-355	N		MS	Schilling & Overall, 2008
124	meprin beta subunit	121-136	N		MS	Becker-Pauly et al., 2011
125	astacin	122-136	N		MS	Becker-Pauly et al., 2011
128	peptidyl-Lys metallopeptidase	1-355	N		MS
129	trypsin 1	1-355	N		MS	Schilling & Overall, 2008
136	trypsin 1	1-355	N		MS	Schilling & Overall, 2008
145	peptidyl-Lys metallopeptidase	1-355	N		MS
149	astacin	146-158	N		MS	Becker-Pauly et al., 2011
182	peptidyl-Lys metallopeptidase	1-355	N		MS
183	trypsin 1	1-355	N		MS	Schilling & Overall, 2008
187	cathepsin K	184-197	N		MS	Schilling & Overall, 2008
196	peptidyl-Lys metallopeptidase	1-355	N		MS
197	trypsin 1	184-203	N		MS	Schilling & Overall, 2008
199	trypsin 1	1-355	N		MS	Schilling & Overall, 2008
201	meprin alpha subunit	1-355	N		MS	Becker-Pauly et al., 2011
201	meprin beta subunit	1-355	N		MS	Becker-Pauly et al., 2011
203	cathepsin B	200-218	N		MS	Biniossek et al., 2011
218	trypsin 1	1-355	N		MS	Schilling & Overall, 2008
328	cathepsin B	281-341	N		MS	Biniossek et al., 2011