Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence Q01105

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
1	unknown peptidase	1-290	P		NT	<%Agarwal et al., 2012[]%>
39	trypsin 1	1-290	N		MS	Schilling & Overall, 2008
46	cathepsin S	40-57	N		MS	Biniossek et al., 2011
56	caspase-6	1-290	P			Klaiman et al., 2008
57	trypsin 1	1-290	N		MS	Schilling & Overall, 2008
68	trypsin 1	1-290	N		MS	Schilling & Overall, 2008
72	trypsin 1	1-290	N		MS	Schilling & Overall, 2008
113	caspase-6	1-290	P			Klaiman et al., 2008
122	trypsin 1	1-290	N		MS	Schilling & Overall, 2008
132	trypsin 1	1-290	N		MS	Schilling & Overall, 2008
153	peptidyl-Lys metallopeptidase	1-290	N		MS
166	peptidyl-Lys metallopeptidase	1-290	N		MS
189	granzyme A	1-290	P
223	caspase-6	1-290	P			Klaiman et al., 2008
248	caspase-6	1-290	P			Klaiman et al., 2008
249	caspase-6	1-290	P			Klaiman et al., 2008
250	caspase-6	1-290	P			Klaiman et al., 2008
251	caspase-6	1-290	P			Klaiman et al., 2008
262	caspase-6	1-290	P			Klaiman et al., 2008
266	caspase-6	1-290	P			Klaiman et al., 2008
273	caspase-6	1-290	P			Klaiman et al., 2008
275	caspase-6	1-290	P			Klaiman et al., 2008
276	caspase-6	1-290	P			Klaiman et al., 2008
277	caspase-6	1-290	P			Klaiman et al., 2008
285	caspase-6	1-290	P			Klaiman et al., 2008