Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P62140

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
1	unknown peptidase	1-327	P		NT	<%Agarwal et al., 2012[]%>
25	matrix metallopeptidase-2	16-37	N		MS	Schilling & Overall, 2008
37	chymotrypsin A (cattle-type)	2-327	N		MS	Schilling & Overall, 2008
42	trypsin 1	2-327	N		MS	Schilling & Overall, 2008
59	trypsin 1	2-327	N		MS	Schilling & Overall, 2008
63	matrix metallopeptidase-2	59-73	N		MS	Schilling & Overall, 2008
73	trypsin 1	2-327	N		MS	Schilling & Overall, 2008
148	peptidyl-Lys metallopeptidase	1-327	N		MS
149	trypsin 1	2-327	N		MS	Schilling & Overall, 2008
166	peptidyl-Lys metallopeptidase	1-327	N		MS
167	trypsin 1	2-327	N		MS	Schilling & Overall, 2008
310	cathepsin L	304-319	N		MS	Biniossek et al., 2011
310	cathepsin S	304-319	N		MS	Biniossek et al., 2011