Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P61981

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
1	unknown peptidase	1-247	P		NT	<%Agarwal et al., 2012[]%>
42	trypsin 1	2-247	N		MS	Schilling & Overall, 2008
49	peptidyl-Lys metallopeptidase	1-247	N		MS
50	trypsin 1	2-247	N		MS	Schilling & Overall, 2008
68	peptidyl-Lys metallopeptidase	1-247	N		MS
132	trypsin 1	2-247	N		MS	Schilling & Overall, 2008
143	trypsin 1	2-247	N		MS	Schilling & Overall, 2008
155	cathepsin L	153-162	N		MS	Biniossek et al., 2011
187	cathepsin S	173-195	N		MS	Biniossek et al., 2011
197	peptidyl-Lys metallopeptidase	1-247	N		MS
198	trypsin 1	2-247	N		MS	Schilling & Overall, 2008
216	peptidyl-Lys metallopeptidase	1-247	N		MS
217	trypsin 1	2-247	N		MS	Schilling & Overall, 2008
227	trypsin 1	2-247	N		MS	Schilling & Overall, 2008