Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P55212

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
23	caspase-3	1-293	P	release of an activation peptide		Srinivasula et al., 1996
23	caspase-6	1-293	P		MU	Klaiman et al., 2009
179	caspase-3	1-293	P	conversion to two-chain form		Srinivasula et al., 1996
179	caspase-6	1-293	P		MU	Klaiman et al., 2009
193	caspase-3	1-293	P	release of an activation peptide		Srinivasula et al., 1996
193	caspase-6	1-293	P		MU	Klaiman et al., 2009