Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P51610

,

Click here to display alignment and conservation of cleavage sites of this sequence with close homologues. This will take a few moments.

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
1	unknown peptidase	1-2035	P		NT	<%Agarwal et al., 2012[]%>
151	cathepsin B	148-163	N		MS	Biniossek et al., 2011
360	cathepsin L	355-369	N		MS	Biniossek et al., 2011
558	trypsin 1	1-1423	N		MS	Schilling & Overall, 2008
578	trypsin 1	1-1423	N		MS	Schilling & Overall, 2008
594	trypsin 1	1-1423	N		MS	Schilling & Overall, 2008
608	trypsin 1	1-1423	N		MS	Schilling & Overall, 2008
713	trypsin 1	1-1423	N		MS	Schilling & Overall, 2008
723	trypsin 1	1-1423	N		MS	Schilling & Overall, 2008
754	cathepsin L	748-770	N		MS	Biniossek et al., 2011
813	trypsin 1	1-1423	N		MS	Schilling & Overall, 2008
820	trypsin 1	1-1423	N		MS	Schilling & Overall, 2008
836	trypsin 1	1-1423	N		MS	Schilling & Overall, 2008
1019	unknown peptidase	1-2035	P		NT	<%Agarwal et al., 2012[]%>
1081	unknown peptidase	1-2035	P		NT	<%Agarwal et al., 2012[]%>
1110	unknown peptidase	1-2035	P		NT	<%Agarwal et al., 2012[]%>
1295	unknown peptidase	1-2035	P		NT	<%Agarwal et al., 2012[]%>
1323	unknown peptidase	1-2035	P		NT	<%Agarwal et al., 2012[]%>
1374	cathepsin L	1356-1388	N		MS	Biniossek et al., 2011
1423	unknown peptidase	1-2035	P		NT	<%Agarwal et al., 2012[]%>
1792	cathepsin L	1775-1803	N		MS	Biniossek et al., 2011
1792	cathepsin S	1775-1803	N		MS	Biniossek et al., 2011
1829	cathepsin L	1820-1840	N		MS	Biniossek et al., 2011