Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P48147

,

Click here to display alignment and conservation of cleavage sites of this sequence with close homologues. This will take a few moments.

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
12	caspase-6	1-710	P			Klaiman et al., 2008
35	caspase-6	1-710	P			Klaiman et al., 2008
111	trypsin 1	1-710	N		MS	Schilling & Overall, 2008
115	caspase-6	1-710	P			Klaiman et al., 2008
128	trypsin 1	1-710	N		MS	Schilling & Overall, 2008
196	trypsin 1	1-710	P	normal turnover		Ito et al., 2004
267	cathepsin S	261-278	N		MS	Biniossek et al., 2011
291	caspase-6	1-710	P			Klaiman et al., 2008
336	caspase-6	1-710	P			Klaiman et al., 2008
523	trypsin 1	1-710	N		MS	Schilling & Overall, 2008
539	trypsin 1	1-710	N		MS	Schilling & Overall, 2008
626	caspase-6	1-710	P			Klaiman et al., 2008