Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P46013

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
1175	meprin alpha subunit	1172-1185	N		MS	Becker-Pauly et al., 2011
1481	granzyme B (Homo sapiens-type)	1-3256	P			Casciola-Rosen et al., 1999
1738	granzyme A	1-3256	N			Van Damme et al., 2010
1746	cathepsin L	1739-1756	N		MS	Biniossek et al., 2011
1746	meprin beta subunit	1743-1756	N		MS	Becker-Pauly et al., 2011
2084	cathepsin L	2081-2097	N		MS	Biniossek et al., 2011
2147	unknown peptidase		P		MS	Mahrus et al., 2008
2151	meprin alpha subunit	1-3256	N		MS	Becker-Pauly et al., 2011
2151	meprin beta subunit	1-3256	N		MS	Becker-Pauly et al., 2011