Searches of the MEROPS database

Display Known Cleavages for a Protein

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Accession:

Sequence P45452

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
19	unknown peptidase	1-471	P		NT	<%Agarwal et al., 2012[]%>
54	membrane-type matrix metallopeptidase-1	20-471	P			Zijlstra et al., 2004
57	plasmin	20-471	P			Knauper et al., 1996
76	matrix metallopeptidase-3	20-471	P	normal turnover		Knauper et al., 1996
84	meprin alpha subunit	104-471	N		MS	Becker-Pauly et al., 2011
84	meprin beta subunit	20-471	N		MS	Becker-Pauly et al., 2011
95	plasmin	20-471	P			Knauper et al., 1996
103	matrix metallopeptidase-2	20-471	P	release of an activation peptide		Knauper et al., 1996
103	matrix metallopeptidase-3	20-471	P	release of an activation peptide		Knauper et al., 1996
103	membrane-type matrix metallopeptidase-1	20-471	P			Knauper et al., 1996
103	plasmin	20-471	P			Knauper et al., 1996
183	matrix metallopeptidase-13	104-471	P	normal turnover		Knauper et al., 1997
264	matrix metallopeptidase-13	104-471	P	normal turnover		Fosang et al., 1996